Amyloidosis diagnostic study of choice: Difference between revisions
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== Overview == | == Overview == | ||
The diagnostic study of choice in amyloidosis is [[Tissue (biology)|tissue]] [[biopsy]] of the affected [[Organ (anatomy)|organ]]. [[Congo red|Congo | The diagnostic study of choice in amyloidosis is [[Tissue (biology)|tissue]] [[biopsy]] of the affected [[Organ (anatomy)|organ]]. [[Congo red|Congo Red staining]] will show apple green birefringence of the tissue sample under polarized light, and subtyping of [[Light chain|light chains]] (for light chain amyloidosis) can be done via [[mass spectrometry]]. [[Bone marrow biopsy]] and organ-specific laboratory measurements are also important ancillary [[Test|tests]]. | ||
== Diagnostic Study of Choice == | == Diagnostic Study of Choice == | ||
The diagnostic study of choice in amyloidosis is [[Tissue (biology)|tissue]] [[biopsy]] of the affected [[Organ (anatomy)|organ]]. [[Congo red|Congo | === Study of Choice === | ||
*'''Tissue biopsy''': A [[Tissue (biology)|tissue]] [[biopsy]] of the affected organ is the gold standard test for amyloidosis. Particular stains can determine the subtype of amyloidosis. | |||
*'''Bone marrow biopsy''': A [[bone marrow biopsy]] is commonly done in patients who have [[light chain]] amyloidosis and suspected concurrent [[multiple myeloma]].<ref name="pmid24145344">{{cite journal| author=Kourelis TV, Kumar SK, Gertz MA, Lacy MQ, Buadi FK, Hayman SR et al.| title=Coexistent multiple myeloma or increased bone marrow plasma cells define equally high-risk populations in patients with immunoglobulin light chain amyloidosis. | journal=J Clin Oncol | year= 2013 | volume= 31 | issue= 34 | pages= 4319-24 | pmid=24145344 | doi=10.1200/JCO.2013.50.8499 | pmc=4881366 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24145344 }} </ref> | * The diagnostic study of choice in amyloidosis is [[Tissue (biology)|tissue]] [[biopsy]] of the affected [[Organ (anatomy)|organ]]. | ||
*'''Organ-specific labs''': If a particular [[Organ (biology)|organ]] is affected, laboratory measurements that are specific to that organ can be measured. For example, if there is liver involvement, liver function tests (such as [[Aspartate transaminase|AST]], [[Alanine transaminase|ALT]], [[Bilirubin|total bilirubin]], and [[alkaline phosphatase]]) should be measured.<ref name="pmid24497558">{{cite journal| author=Mahmood S, Palladini G, Sanchorawala V, Wechalekar A| title=Update on treatment of light chain amyloidosis. | journal=Haematologica | year= 2014 | volume= 99 | issue= 2 | pages= 209-21 | pmid=24497558 | doi=10.3324/haematol.2013.087619 | pmc=3912950 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24497558 }} </ref> | * [[Congo red|Congo Red staining]] will show apple green birefringence of the tissue sample under polarized light, and subtyping of light chains (for light chain amyloidosis) can be done via [[mass spectrometry]]. | ||
* [[Mass spectrometry]] is only applicable to [[light chain]] amyloidosis. | |||
*'''Tissue biopsy''': A [[Tissue (biology)|tissue]] [[biopsy]] of the affected organ is the [[Gold standard (test)|gold standard test]] for amyloidosis. Particular stains can determine the subtype of amyloidosis. | |||
*'''Bone marrow biopsy''': A [[bone marrow biopsy]] is commonly done in [[Patient|patients]] who have [[light chain]] amyloidosis and suspected concurrent [[multiple myeloma]].<ref name="pmid24145344">{{cite journal| author=Kourelis TV, Kumar SK, Gertz MA, Lacy MQ, Buadi FK, Hayman SR et al.| title=Coexistent multiple myeloma or increased bone marrow plasma cells define equally high-risk populations in patients with immunoglobulin light chain amyloidosis. | journal=J Clin Oncol | year= 2013 | volume= 31 | issue= 34 | pages= 4319-24 | pmid=24145344 | doi=10.1200/JCO.2013.50.8499 | pmc=4881366 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24145344 }} </ref> | |||
*'''Organ-specific labs''': If a particular [[Organ (biology)|organ]] is affected, laboratory measurements that are specific to that organ can be measured. For example, if there is liver involvement, [[liver function tests]] (such as [[Aspartate transaminase|AST]], [[Alanine transaminase|ALT]], [[Bilirubin|total bilirubin]], and [[alkaline phosphatase]]) should be measured.<ref name="pmid24497558">{{cite journal| author=Mahmood S, Palladini G, Sanchorawala V, Wechalekar A| title=Update on treatment of light chain amyloidosis. | journal=Haematologica | year= 2014 | volume= 99 | issue= 2 | pages= 209-21 | pmid=24497558 | doi=10.3324/haematol.2013.087619 | pmc=3912950 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24497558 }} </ref> | |||
Revision as of 21:43, 25 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
The diagnostic study of choice in amyloidosis is tissue biopsy of the affected organ. Congo Red staining will show apple green birefringence of the tissue sample under polarized light, and subtyping of light chains (for light chain amyloidosis) can be done via mass spectrometry. Bone marrow biopsy and organ-specific laboratory measurements are also important ancillary tests.
Diagnostic Study of Choice
Study of Choice
- The diagnostic study of choice in amyloidosis is tissue biopsy of the affected organ.
- Congo Red staining will show apple green birefringence of the tissue sample under polarized light, and subtyping of light chains (for light chain amyloidosis) can be done via mass spectrometry.
- Mass spectrometry is only applicable to light chain amyloidosis.
- Tissue biopsy: A tissue biopsy of the affected organ is the gold standard test for amyloidosis. Particular stains can determine the subtype of amyloidosis.
- Bone marrow biopsy: A bone marrow biopsy is commonly done in patients who have light chain amyloidosis and suspected concurrent multiple myeloma.[1]
- Organ-specific labs: If a particular organ is affected, laboratory measurements that are specific to that organ can be measured. For example, if there is liver involvement, liver function tests (such as AST, ALT, total bilirubin, and alkaline phosphatase) should be measured.[2]
References
- ↑ Kourelis TV, Kumar SK, Gertz MA, Lacy MQ, Buadi FK, Hayman SR; et al. (2013). "Coexistent multiple myeloma or increased bone marrow plasma cells define equally high-risk populations in patients with immunoglobulin light chain amyloidosis". J Clin Oncol. 31 (34): 4319–24. doi:10.1200/JCO.2013.50.8499. PMC 4881366. PMID 24145344.
- ↑ Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (2014). "Update on treatment of light chain amyloidosis". Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.