Alcoholic hepatitis natural history, complications and prognosis: Difference between revisions

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== Overview==
== Overview==
[[Alcoholic]] [[liver disease]] may progress to [[fatty liver]], [[ hepatic]][[steatosis]], [[Alcoholic hepatitis]], [[alcoholic]] [[steatonecrosis]],[[fibrosis]], [[cirrhosis]] and [[hepatocellular carcinoma]]. [[Complications]] of [[Alcoholic hepatitis]] include [[variceal [[hemorrhage]],[[hepatic]] [[encephalopathy]],[[ascites]],[[Coagulopathy]], [[thrombocytopenia]],[[spontaneous bacterial peritonitis]], and[[iron]] overload. Different scoring systems were presented to predict the [[prognosis]] and [[mortality]] among patients with [[Alcoholic hepatitis]]. The most recent and accurate one is called Asymmetric dimethylarginine (ADMA) score.
[[Alcoholic]] [[liver disease]] may progress to [[fatty liver]], [[ hepatic]][[steatosis]], [[Alcoholic hepatitis]], [[alcoholic]] [[steatonecrosis]],[[fibrosis]], [[cirrhosis]] and [[hepatocellular carcinoma]]. [[Complications]] of [[Alcoholic hepatitis]] include [[variceal [[hemorrhage]],[[hepatic]] [[encephalopathy]],[[ascites]],[[Coagulopathy]], [[thrombocytopenia]],[[spontaneous bacterial peritonitis]], and [[iron]] overload. Different scoring systems were presented to predict the [[prognosis]] and [[mortality]] among patients with [[Alcoholic hepatitis]]. The most recent and accurate one is called Asymmetric dimethylarginine (ADMA) score.


==Natural history, complication, and prognosis==
==Natural history, complication, and prognosis==

Revision as of 16:59, 2 August 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]

Overview

Alcoholic liver disease may progress to fatty liver, hepaticsteatosis, Alcoholic hepatitis, alcoholic steatonecrosis,fibrosis, cirrhosis and hepatocellular carcinoma. Complications of Alcoholic hepatitis include [[variceal hemorrhage,hepatic encephalopathy,ascites,Coagulopathy, thrombocytopenia,spontaneous bacterial peritonitis, and iron overload. Different scoring systems were presented to predict the prognosis and mortality among patients with Alcoholic hepatitis. The most recent and accurate one is called Asymmetric dimethylarginine (ADMA) score.

Natural history, complication, and prognosis

Natural history

Complication

Prognosis

References

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  2. Testino G (2013). "Alcoholic hepatitis". J Med Life. 6 (2): 161–7. PMC 3725441. PMID 23904876.
  3. "Alcoholic Hepatitis - StatPearls - NCBI Bookshelf".
  4. Frazier TH, Stocker AM, Kershner NA, Marsano LS, McClain CJ (2011). "Treatment of alcoholic liver disease". Therap Adv Gastroenterol. 4 (1): 63–81. doi:10.1177/1756283X10378925. PMC 3036962. PMID 21317995.
  5. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C; et al. (2018). "Alcoholic liver disease". Nat Rev Dis Primers. 4 (1): 16. doi:10.1038/s41572-018-0014-7. PMID 30115921.
  6. Lourens S, Sunjaya DB, Singal A, Liangpunsakul S, Puri P, Sanyal A; et al. (2017). "Acute Alcoholic Hepatitis: Natural History and Predictors of Mortality Using a Multicenter Prospective Study". Mayo Clin Proc Innov Qual Outcomes. 1 (1): 37–48. doi:10.1016/j.mayocpiqo.2017.04.004. PMC 6134907. PMID 30225400.
  7. Parker R, Aithal GP, Becker U, Gleeson D, Masson S, Wyatt JI; et al. (2019). "Natural history of histologically proven alcohol-related liver disease: A systematic review". J Hepatol. 71 (3): 586–593. doi:10.1016/j.jhep.2019.05.020. PMID 31173814.
  8. O'Shea RS, Dasarathy S, McCullough AJ, Practice Guideline Committee of the American Association for the Study of Liver Diseases. Practice Parameters Committee of the American College of Gastroenterology (2010). "Alcoholic liver disease". Hepatology. 51 (1): 307–28. doi:10.1002/hep.23258. PMID 20034030.
  9. Al Sibae MR, Cappell MS (2011). "Accuracy of MELD scores in predicting mortality in decompensated cirrhosis from variceal bleeding, hepatorenal syndrome, alcoholic hepatitis, or acute liver failure as well as mortality after non-transplant surgery or TIPS". Dig Dis Sci. 56 (4): 977–87. doi:10.1007/s10620-010-1390-3. PMID 20844956.
  10. Forrest EH, Evans CD, Stewart S, Phillips M, Oo YH, McAvoy NC; et al. (2005). "Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score". Gut. 54 (8): 1174–9. doi:10.1136/gut.2004.050781. PMC 1774903. PMID 16009691.
  11. Mookerjee RP, Malaki M, Davies NA, Hodges SJ, Dalton RN, Turner C; et al. (2007). "Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis". Hepatology. 45 (1): 62–71. doi:10.1002/hep.21491. PMID 17187433.

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