AGCE gene transcriptions

Associate Editor(s)-in-Chief: Henry A. Hoff

This is a restored image of a group of Ainu men between 1863 and early 1870s. Credit: Felice Beato.

Angiotensinogen core promoter element 1 (AGCE1) is an example of a core promoter element that may occur in a DNA sequence for only one gene (the human angiotensinogen gene angiotensin).

"[T]he core promoter element 1 (AGCE1) of the human angiotensinogen gene (AGT) ... acts as a critical regulator of AGT transcription".^[1]

Human genes

Gene ID: 183 is angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ] has the official symbol AGT.^[2]

Consensus sequences

The consensus sequence is 3'-A/C-T-C/T-5'.^[1] By convention, this is 5'-MTY-3' on the mRNA, with T replaced by uracil (U).

The core nucleotides for AGCE1 include 3'-A/C-T-C/T-G-T-G-5', "located between the TATA box and transcription initiation site (positions −25 to −1) is an authentic regulator of human AG transcription."^[3]

A1BG gene transcriptions

An AGCE1 occurs at 3'-ATC-5', in the nucleotides before the transcription start site for the transcription of A1BG, which ends 5 bp upstream from the TSS and is the only AGCE1 within -25 and -1 bp of the TSS. Usually, the AGCE1 spans -20 to -18 bp, when a TATA box is present.^[1]

However, for the transcription of A1BG, there is no TATA box and the core nucleotides 3'-GTG-5' do not occur on either side of 3'-ATC-5'.

Hypotheses

AGCE1 does not participate in the transcription of A1BG.

AGCE samplings

AGCE, negative strand, negative direction, looking for (A/C)T(C/T)GTG: 4 between 340 and 3914.
AGCE, negative strand, positive direction, looking for (A/C)T(C/T)GTG: 2, CTCGTG at 4376, ATTGTG at 2679.
AGCE, positive strand, positive direction, looking for (A/C)T(C/T)GTG: 6 between 855 and 3739 and complements.
AGCEci, negative strand, negative direction, looking for CAC(A/G)A(G/T): 2, CACGAG at 4403, CACGAT at 336.
AGCEci, negative strand, positive direction, looking for CAC(A/G)A(G/T): 1, CACGAG at 243.
AGCEci, positive strand, negative direction, looking for CAC(A/G)A(G/T): 10 between 435 and 4472.
AGCEci, positive strand, positive direction, looking for CAC(A/G)A(G/T): 3 between 107 and 3152 and complements.

Core promoters

AGCE1 can occur upstream from -25 to -1 base pairs (bp)s of the transcription start site.^[1]

Negative direction: 3'-CACGAG-5' at 4472 and complements.

Positive direction: 3'-CTCGTG-5' at 4376 and complements.

Proximal promoters

Negative direction: 3'-CACGAG-5' at 4403 and complements.

Distal promoters

Negative direction: 3'-CTCGTG-5' at 3914, 3'-CTTGTG-5' at 3669, 3'-CACAAG-5' at 3634, 3'-CACAAT-5' at 3515, 3'-CACGAG-5' at 3232, 3'-CACAAG-5' at 2244, 3'-ATCGTG-5' at 2096, 3'-CACAAT-5' at 1721, 3'-CACGAG-5' at 1182, 3'-CACGAG-5' at 708, 3'-CACGAG-5' at 572, 3'-CACGAG-5' at 435, 3'-ATTGTG-5' at 340, 3'-CACGAT-5' at 336 and complements.

Positive direction: 3'-CTCGTG-5' at 3739, 3'-CACGAG-5' at 3152, 3'-CTTGTG-5' at 3095, 3'-ATTGTG-5' at 2679, 3'-CACGAG-5' at 2090, 3'-CTCGTG-5' at 1627, 3'-CTCGTG-5' at 1207, 3'-CTCGTG-5' at 955, 3'-CTCGTG-5' at 855, 3'-CACGAG-5' at 243, 3'-CACAAG-5' at 107 and complements.

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

Initial content for this page in some instances came from Wikiversity.

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Noriyuki Sato; Tomohiro Katsuya; Hiromi Rakugi; Seiju Takami; Yukiko Nakata; Tetsuro Miki; Jitsuo Higaki; Toshio Ogihara (September 1997). "Association of Variants in Critical Core Promoter Element of Angiotensinogen Gene With Increased Risk of Essential Hypertension in Japanese". Hypertension. 30 (3 Pt 1): 321–5. doi:10.1161/01.HYP.30.3.321. PMID 9314411. Retrieved 2012-02-20.
↑ HGNC (February 7, 2013). "AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2013-02-10.
↑ Kazuyuki Yanai, Tomoko Saito, Keiko Hirota, Hideyuki Kobayashi, Kazuo Murakami and Akiyoshi Fukamizu (28 November 1997). "Molecular Variation of the Human Angiotensinogen Core Promoter Element Located between the TATA Box and Transcription Initiation Site Affects Its Transcriptional Activity". The Journal of Biological Chemistry. 272 (48): 30558–62. PMID 9374551. Retrieved 2012-02-20.

External links

{{Phosphate biochemistry}}

[Sato-1] 1.0 ^1.1 ^1.2 ^1.3 Noriyuki Sato; Tomohiro Katsuya; Hiromi Rakugi; Seiju Takami; Yukiko Nakata; Tetsuro Miki; Jitsuo Higaki; Toshio Ogihara (September 1997). "Association of Variants in Critical Core Promoter Element of Angiotensinogen Gene With Increased Risk of Essential Hypertension in Japanese". Hypertension. 30 (3 Pt 1): 321–5. doi:10.1161/01.HYP.30.3.321. PMID 9314411. Retrieved 2012-02-20.

[HGNC183-2] HGNC (February 7, 2013). "AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2013-02-10.

[Yanai-3] Kazuyuki Yanai, Tomoko Saito, Keiko Hirota, Hideyuki Kobayashi, Kazuo Murakami and Akiyoshi Fukamizu (28 November 1997). "Molecular Variation of the Human Angiotensinogen Core Promoter Element Located between the TATA Box and Transcription Initiation Site Affects Its Transcriptional Activity". The Journal of Biological Chemistry. 272 (48): 30558–62. PMID 9374551. Retrieved 2012-02-20.

[1]

[2]

[3]

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