AGCE gene transcriptions: Difference between revisions

Revision as of 15:26, 23 October 2021

Associate Editor(s)-in-Chief: Henry A. Hoff

This is a restored image of a group of Ainu men between 1863 and early 1870s. Credit: Felice Beato.

Angiotensinogen core promoter element 1 (AGCE1) is an example of a core promoter element that may occur in a DNA sequence for only one gene (the human angiotensinogen gene angiotensin).

"[T]he core promoter element 1 (AGCE1) of the human angiotensinogen gene (AGT) ... acts as a critical regulator of AGT transcription".^[1]

Human genes

Gene ID: 183 is angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ] has the official symbol AGT.^[2]

Consensus sequences

The consensus sequence is (A/C)T(C/T).^[1] By convention, this is MTY on the mRNA, with T replaced by uracil (U).

The core nucleotides for AGCE1 include (A/C)T(C/T)GTG, "located between the TATA box and transcription initiation site (positions −25 to −1) is an authentic regulator of human AG transcription."^[3]

AGCE1 can occur upstream from -25 to -1 base pairs (bp)s of the transcription start site.^[1]

A1BG gene transcriptions

An AGCE1 occurs at ATC, in the nucleotides before the transcription start site for the transcription of A1BG, which ends 5 bp upstream from the TSS and is the only AGCE1 within -25 and -1 bp of the TSS. Usually, the AGCE1 spans -20 to -18 bp, when a TATA box is present.^[1]

However, for the transcription of A1BG, there is no TATA box and the core nucleotides GTG do not occur on either side of ATC.

Hypotheses

AGCE1 does not participate in the transcription of A1BG.

AGCE samplings

AGCE, negative strand, negative direction, looking for (A/C)T(C/T)GTG: CTCGTG at 3914, CTTGTG at 3669, ATCGTG at 2096, ATTGTG at 340.
AGCE, negative strand, positive direction, looking for (A/C)T(C/T)GTG: 2, CTCGTG at 4376, ATTGTG at 2679.
AGCE, positive strand, negative direction, looking for (A/C)T(C/T)GTG: 0.
AGCE, positive strand, positive direction, looking for (A/C)T(C/T)GTG: 6, CTCGTG at 3739, CTTGTG at 3095, CTCGTG at 1627, CTCGTG at 1207, CTCGTG at 955, CTCGTG at 855.
AGCEci, negative strand, negative direction, looking for CAC(A/G)A(G/T): 2, CACGAG at 4403, CACGAT at 336.
AGCEci, negative strand, positive direction, looking for CAC(A/G)A(G/T): 1, CACGAG at 243.
AGCEci, positive strand, negative direction, looking for CAC(A/G)A(G/T): 10, CACGAG at 4472, CACAAG at 3634, CACAAT at 3515, CACGAG at 3232, CACAAG at 2244, CACAAT at 1721, CACGAG at 1182, CACGAG at 708, CACGAG at 572, CACGAG at 435.
AGCEci, positive strand, positive direction, looking for CAC(A/G)A(G/T): 3, CACGAG at 3152, CACGAG at 2090, CACAAG at 107.

AGCE UTR promoters

Negative strand, negative direction: CACGAG at 4403, CTCGTG at 3914, CTTGTG at 3669.
Positive strand, negative direction: CACGAG at 4472, CACAAG at 3634, CACAAT at 3515, CACGAG at 3232.

AGCE core promoters

Negative strand, positive direction: CTCGTG at 4376.

AGCE distal promoters

Negative strand, negative direction: ATCGTG at 2096, ATTGTG at 340, CACGAT at 336.
Positive strand, negative direction: CACAAG at 2244, CACAAT at 1721, CACGAG at 1182, CACGAG at 708, CACGAG at 572, CACGAG at 435.

Negative strand, positive direction: ATTGTG at 2679, CACGAG at 243.
Positive strand, positive direction: CTCGTG at 3739, CACGAG at 3152, CTTGTG at 3095, CACGAG at 2090, CTCGTG at 1627, CTCGTG at 1207, CTCGTG at 955, CTCGTG at 855, CACAAG at 107.

AGCE random dataset samplings

RDr0: 0.
RDr1: 0.
RDr2: 0.
RDr3: 0.
RDr4: 0.
RDr5: 0.
RDr6: 0.
RDr7: 0.
RDr8: 0.
RDr9: 0.
RDr0ci: 0.
RDr1ci: 0.
RDr2ci: 0.
RDr3ci: 0.
RDr4ci: 0.
RDr5ci: 0.
RDr6ci: 0.
RDr7ci: 0.
RDr8ci: 0.
RDr9ci: 0.

RDr UTRs

RDr core promoters

RDr proximal promoters

RDr distal promoters

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

Initial content for this page in some instances came from Wikiversity.

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Noriyuki Sato; Tomohiro Katsuya; Hiromi Rakugi; Seiju Takami; Yukiko Nakata; Tetsuro Miki; Jitsuo Higaki; Toshio Ogihara (September 1997). "Association of Variants in Critical Core Promoter Element of Angiotensinogen Gene With Increased Risk of Essential Hypertension in Japanese". Hypertension. 30 (3 Pt 1): 321–5. doi:10.1161/01.HYP.30.3.321. PMID 9314411. Retrieved 2012-02-20.
↑ HGNC (February 7, 2013). "AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2013-02-10.
↑ Kazuyuki Yanai, Tomoko Saito, Keiko Hirota, Hideyuki Kobayashi, Kazuo Murakami and Akiyoshi Fukamizu (28 November 1997). "Molecular Variation of the Human Angiotensinogen Core Promoter Element Located between the TATA Box and Transcription Initiation Site Affects Its Transcriptional Activity". The Journal of Biological Chemistry. 272 (48): 30558–62. PMID 9374551. Retrieved 2012-02-20.

External links

{{Phosphate biochemistry}}

[Sato-1] 1.0 ^1.1 ^1.2 ^1.3 Noriyuki Sato; Tomohiro Katsuya; Hiromi Rakugi; Seiju Takami; Yukiko Nakata; Tetsuro Miki; Jitsuo Higaki; Toshio Ogihara (September 1997). "Association of Variants in Critical Core Promoter Element of Angiotensinogen Gene With Increased Risk of Essential Hypertension in Japanese". Hypertension. 30 (3 Pt 1): 321–5. doi:10.1161/01.HYP.30.3.321. PMID 9314411. Retrieved 2012-02-20.

[HGNC183-2] HGNC (February 7, 2013). "AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2013-02-10.

[Yanai-3] Kazuyuki Yanai, Tomoko Saito, Keiko Hirota, Hideyuki Kobayashi, Kazuo Murakami and Akiyoshi Fukamizu (28 November 1997). "Molecular Variation of the Human Angiotensinogen Core Promoter Element Located between the TATA Box and Transcription Initiation Site Affects Its Transcriptional Activity". The Journal of Biological Chemistry. 272 (48): 30558–62. PMID 9374551. Retrieved 2012-02-20.

[1]

[2]

[3]

@@ Line 65: / Line 65: @@
 # AGCE, negative strand, negative direction, looking for (A/C)T(C/T)GTG:  CTCGTG at 3914, CTTGTG at 3669, ATCGTG at 2096, ATTGTG at 340.
 # AGCE, negative strand, positive direction, looking for (A/C)T(C/T)GTG: 2, CTCGTG at 4376, ATTGTG at 2679.
+# AGCE, positive strand, negative direction, looking for (A/C)T(C/T)GTG: 0.
 # AGCE, positive strand, positive direction, looking for (A/C)T(C/T)GTG: 6, CTCGTG at 3739, CTTGTG at 3095, CTCGTG at 1627, CTCGTG at 1207, CTCGTG at 955, CTCGTG at 855.
 # AGCEci, negative strand, negative direction, looking for CAC(A/G)A(G/T): 2, CACGAG at 4403, CACGAT at 336.

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transcription factor II A gene transcriptions General transcription factor II B gene transcriptions General transcription factor II D gene transcriptions General transcription factor II F gene transcriptions General transcription factor II H gene transcriptions General transcription factor gene transcriptions Gene transcriptions GGC triplet gene transcriptions Gibberellin responsive element gene transcriptions GLM box gene transcriptions Glucocorticoid response element gene transcriptions Grainy head gene transcriptions Grainy head transcription factor gene transcriptions Growth hormone response element gene transcriptions GT boxes Hac1p gene transcriptions Hair color gene expressions H and ACA box gene transcriptions H box gene transcriptions Heat-responsive element gene transcriptions Hex sequence gene transcriptions HMG box gene transcriptions HNF gene transcriptions Homeobox gene transcriptions Hsf1p gene transcriptions HY box gene transcriptions Hybrid C, A boxes Hybrid C, G boxes Hybrid C, T boxes Hypoxia-inducible factor gene transcriptions Hypoxia response elements I box gene transcriptions Initiator element gene transcriptions Initiator-like element gene transcriptions Inositol/choline-responsive elements Interaction gene transcriptions Interferon regulatory factors Inverse copy gene transcriptions Jasmonic acid-responsive element gene transcriptions K-boxes Kozak sequence gene transcriptions Kruppel-associated box gene transcriptions Krüppel-like factor gene transcriptions L box gene transcriptions Leu3 gene transcriptions M35 box gene transcriptions MADS box gene transcriptions Maf recognition element gene transcriptions M box gene transcriptions Mcm1 regulatory factor gene transcriptions Met31p box gene transcriptions Metal responsive element gene transcriptions Middle sporulation element gene transcriptions Mig1p gene transcriptions Model samplings Motif ten element gene transcriptions Msn2,4p gene transcriptions Musashi binding element gene transcriptions MYB recognition element gene transcriptions Myelocytomatosis transcription factor gene transcriptions Myocyte enhancer factor gene transcriptions N-boxes Ndt80p gene transcriptions Nuclear factor 1 Nuclear factor 𝜿B Nuclear factor gene transcriptions Nuclear factor of activated T cell gene transcriptions (NFAT) Nuclear factor Y gene transcriptions Nutrient-sensing response element gene transcriptions Oaf1p gene transcriptions ORE1 binding site gene transcriptions p53 response element gene transcriptions P63 DNA-binding site gene transcriptions P box gene transcriptions Pdr1,3p gene transcriptions Peroxisome proliferator hormone response element gene transcriptions Phosphate starvation-response transcription factor gene transcriptions Pollen1 element gene transcriptions Polycomb response element gene transcriptions Preinitiation complex Preinitiation complex gene transcriptions Pribnow box gene transcriptions Prolamin box gene transcriptions Promoter gene transcriptions Proximal promoter gene transcriptions Promoter occurrence gene transcriptions Pyrimidine box gene transcriptions Q element gene transcriptions Rap1 regulatory factor gene transcriptions Reb1 general regulatory factor gene transcriptions Retinoblastoma control element gene transcriptions Retinoic acid response element gene transcriptions Rgt1p gene transcriptions Rlm1p gene transcriptions RNA polymerase II gene transcriptions RNA polymerase II holoenzyme complex Root specific element gene transcriptions ROR-response element gene transcriptions Rox1p gene transcriptions Rpn4p gene transcriptions R response element gene transcriptions SARE gene transcriptions Seed-specific element gene transcriptions Serum response element gene transcriptions Servenius sequence gene transcriptions Shoot specific element gene transcriptions Sip4p gene transcriptions Smp1p gene transcriptions Sp1 gene transcriptions Spaceflight gene expressions Specificity protein gene transcriptions STAT gene transcriptions Ste12p gene transcriptions Sterol response element gene transcriptions Sucrose box gene transcriptions Synaptic Activity-Responsive Elements TACTAAC box gene transcriptions TAGteam gene transcriptions Tapetum box gene transcriptions TATA binding protein associated factor gene transcriptions TATA binding protein gene transcriptions TATA box gene transcriptions TAT box gene transcriptions TATC box gene transcriptions Tbf1 regulatory factor gene transcriptions T box gene transcriptions TCCACCATA element gene transcriptions TC element gene transcriptions TCT gene transcriptions TEA consensus sequence gene transcriptions Tec1p gene transcriptions Telomeric repeat DNA-binding factor gene transcriptions Tetradecanoylphorbol-13-acetate response element gene transcriptions TGF-β control elements (TCEs) TGF-β inhibitory elements (TIEs) Thyroid hormone response element gene transcriptions Transcriptional regulation Transcription bubble gene transcriptions Transcription factor gene transcriptions Transcription factor 3 gene transcriptions Transcription factory gene transcriptions Transcription start site gene transcriptions Translational control sequence gene transcriptions U box gene transcriptions Unfolded protein response element gene transcriptions Upstream response element gene transcriptions Upstream stimulatory factor gene transcriptions UTR promoter gene transcriptions V and P box gene transcriptions V box gene transcriptions Vhr1p gene transcriptions Vitamin D response element gene transcriptions W box gene transcriptions X box gene transcriptions Xbp1p gene transcriptions X core promoter element gene transcriptions Xenobiotic response element gene transcriptions Xenobiotic responsive element gene transcriptions Yap1p,2p gene transcriptions Y box gene transcriptions YY1 gene transcriptions Zap1p gene transcriptions Z box gene transcriptions Zinc responsive element gene transcriptions