ADCY5: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Adenylyl cyclase type 5''' is an [[enzyme]] that in humans is encoded by the ''ADCY5'' [[gene]].<ref name="pmid10481931">{{cite journal | vauthors = Raimundo S, Giray J, Volff JN, Schwab M, Altenbuchner J, Ratge D, Wisser H | title = Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues | journal = Clin Chim Acta | volume = 285 | issue = 1–2 | pages = 155–61 | date = October 1999 | pmid = 10481931 | pmc =  | doi = 10.1016/S0009-8981(99)00067-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADCY5 adenylate cyclase 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=111| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_ADCY5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1azs.
| PDB = {{PDB2|1azs}}, {{PDB2|1cjk}}, {{PDB2|1cjt}}, {{PDB2|1cju}}, {{PDB2|1cjv}}, {{PDB2|1cs4}}, {{PDB2|1cul}}, {{PDB2|1tl7}}, {{PDB2|1u0h}}, {{PDB2|2gvd}}, {{PDB2|2gvz}}
| Name = Adenylate cyclase 5
| HGNCid = 236
| Symbol = ADCY5
| AltSymbols =;
| OMIM = 600293
| ECnumber = 
| Homologene = 11213
| MGIid = 99673
| GeneAtlas_image1 = PBB_GE_ADCY5_gnf1h01583_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ADCY5_gnf1h01584_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004016 |text = adenylate cyclase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001973 |text = adenosine receptor signaling pathway}} {{GNF_GO|id=GO:0006171 |text = cAMP biosynthetic process}} {{GNF_GO|id=GO:0007191 |text = dopamine receptor, adenylate cyclase activating pathway}} {{GNF_GO|id=GO:0007195 |text = dopamine receptor, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0050885 |text = regulation of balance}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 111
    | Hs_Ensembl = ENSG00000173175
    | Hs_RefseqProtein = NP_899200
    | Hs_RefseqmRNA = NM_183357
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 124486089
    | Hs_GenLoc_end = 124650082
    | Hs_Uniprot = O95622
    | Mm_EntrezGene = 224129
    | Mm_Ensembl = ENSMUSG00000022840
    | Mm_RefseqmRNA = XM_916755
    | Mm_RefseqProtein = XP_921848
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 35074624
    | Mm_GenLoc_end = 35224118
    | Mm_Uniprot = P84309
  }}
}}
'''Adenylate cyclase 5''', also known as '''ADCY5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADCY5 adenylate cyclase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=111| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
ADCY5 has been shown to [[Protein-protein interaction|interact]] with [[RGS2]].<ref name="pmid12604604">{{cite journal | vauthors = Salim S, Sinnarajah S, Kehrl JH, Dessauer CW | title = Identification of RGS2 and type V adenylyl cyclase interaction sites | journal = J. Biol. Chem. | volume = 278 | issue = 18 | pages = 15842–9 | date = May 2003 | pmid = 12604604 | doi = 10.1074/jbc.M210663200 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
==External links==
* {{UCSC gene info|ADCY5}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yoshimura M, Cooper DM | title = Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 15 | pages = 6716–20 | year = 1992 | pmid = 1379717 | pmc = 49574 | doi = 10.1073/pnas.89.15.6716 }}
| citations =
* {{cite journal | vauthors = Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, Ishikawa Y | title = Regulation of adenylyl cyclase by protein kinase A | journal = J. Biol. Chem. | volume = 270 | issue = 21 | pages = 12481–4 | year = 1995 | pmid = 7759492 | doi = 10.1074/jbc.270.21.12481 }}
*{{cite journal | author=Yoshimura M, Cooper DM |title=Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 15 |pages= 6716-20 |year= 1992 |pmid= 1379717 |doi= }}
* {{cite journal | vauthors = Haber N, Stengel D, Defer N, Roeckel N, Mattei MG, Hanoune J | title = Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI | journal = Hum. Genet. | volume = 94 | issue = 1 | pages = 69–73 | year = 1994 | pmid = 8034296 | doi = 10.1007/BF02272844 }}
*{{cite journal | author=Iwami G, Kawabe J, Ebina T, ''et al.'' |title=Regulation of adenylyl cyclase by protein kinase A. |journal=J. Biol. Chem. |volume=270 |issue= 21 |pages= 12481-4 |year= 1995 |pmid= 7759492 |doi= }}
* {{cite journal | vauthors = Kawabe J, Iwami G, Ebina T, Ohno S, Katada T, Ueda Y, Homcy CJ, Ishikawa Y | title = Differential activation of adenylyl cyclase by protein kinase C isoenzymes | journal = J. Biol. Chem. | volume = 269 | issue = 24 | pages = 16554–8 | year = 1994 | pmid = 8206971 | doi =  }}
*{{cite journal | author=Haber N, Stengel D, Defer N, ''et al.'' |title=Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI. |journal=Hum. Genet. |volume=94 |issue= 1 |pages= 69-73 |year= 1994 |pmid= 8034296 |doi= }}
* {{cite journal | vauthors = Scholich K, Barbier AJ, Mullenix JB, Patel TB | title = Characterization of soluble forms of nonchimeric type V adenylyl cyclases | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 7 | pages = 2915–20 | year = 1997 | pmid = 9096321 | pmc = 20297 | doi = 10.1073/pnas.94.7.2915 }}
*{{cite journal | author=Kawabe J, Iwami G, Ebina T, ''et al.'' |title=Differential activation of adenylyl cyclase by protein kinase C isoenzymes. |journal=J. Biol. Chem. |volume=269 |issue= 24 |pages= 16554-8 |year= 1994 |pmid= 8206971 |doi=  }}
* {{cite journal | vauthors = Sunahara RK, Dessauer CW, Whisnant RE, Kleuss C, Gilman AG | title = Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase | journal = J. Biol. Chem. | volume = 272 | issue = 35 | pages = 22265–71 | year = 1997 | pmid = 9268375 | doi = 10.1074/jbc.272.35.22265 }}
*{{cite journal | author=Scholich K, Barbier AJ, Mullenix JB, Patel TB |title=Characterization of soluble forms of nonchimeric type V adenylyl cyclases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 2915-20 |year= 1997 |pmid= 9096321 |doi= }}
* {{cite journal | vauthors = Scholich K, Wittpoth C, Barbier AJ, Mullenix JB, Patel TB | title = Identification of an intramolecular interaction between small regions in type V adenylyl cyclase that influences stimulation of enzyme activity by Gsα | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 18 | pages = 9602–7 | year = 1997 | pmid = 9275169 | pmc = 23231 | doi = 10.1073/pnas.94.18.9602 }}
*{{cite journal | author=Sunahara RK, Dessauer CW, Whisnant RE, ''et al.'' |title=Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22265-71 |year= 1997 |pmid= 9268375 |doi= }}
* {{cite journal | vauthors = Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG | title = Identification of a Gialpha binding site on type V adenylyl cyclase | journal = J. Biol. Chem. | volume = 273 | issue = 40 | pages = 25831–9 | year = 1998 | pmid = 9748257 | doi = 10.1074/jbc.273.40.25831 }}
*{{cite journal | author=Scholich K, Wittpoth C, Barbier AJ, ''et al.'' |title=Identification of an intramolecular interaction between small regions in type V adenylyl cyclase that influences stimulation of enzyme activity by Gsalpha. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9602-7 |year= 1997 |pmid= 9275169 |doi= }}
* {{cite journal | vauthors = Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP | title = Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1 | journal = Pflugers Arch. | volume = 437 | issue = 4 | pages = 538–46 | year = 1999 | pmid = 10089566 | doi = 10.1007/s004240050815 }}
*{{cite journal | author=Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG |title=Identification of a Gialpha binding site on type V adenylyl cyclase. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25831-9 |year= 1998 |pmid= 9748257 |doi= }}
* {{cite journal | vauthors = Speth C, Joebstl B, Barcova M, Dierich MP | title = HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones | journal = AIDS | volume = 14 | issue = 6 | pages = 629–36 | year = 2000 | pmid = 10807185 | doi = 10.1097/00002030-200004140-00001 }}
*{{cite journal | author=Barcova M, Speth C, Kacani L, ''et al.'' |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflugers Arch. |volume=437 |issue= 4 |pages= 538-46 |year= 1999 |pmid= 10089566 |doi= }}
* {{cite journal | vauthors = Patke CL, Shearer WT | title = gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression | journal = J. Allergy Clin. Immunol. | volume = 105 | issue = 5 | pages = 975–82 | year = 2000 | pmid = 10808179 | doi = 10.1067/mai.2000.105315 }}
*{{cite journal | author=Raimundo S, Giray J, Volff JN, ''et al.'' |title=Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues. |journal=Clin. Chim. Acta |volume=285 |issue= 1-2 |pages= 155-61 |year= 1999 |pmid= 10481931 |doi= }}
* {{cite journal | vauthors = Patrizio M, Colucci M, Levi G | title = Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures | journal = J. Neurochem. | volume = 77 | issue = 2 | pages = 399–407 | year = 2001 | pmid = 11299302 | doi = 10.1046/j.1471-4159.2001.00249.x }}
*{{cite journal | author=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629-36 |year= 2000 |pmid= 10807185 |doi= }}
* {{cite journal | vauthors = Côté M, Guillon G, Payet MD, Gallo-Payet N | title = Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland | journal = J. Clin. Endocrinol. Metab. | volume = 86 | issue = 9 | pages = 4495–503 | year = 2001 | pmid = 11549699 | doi = 10.1210/jc.86.9.4495 }}
*{{cite journal | author=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975-82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
* {{cite journal | vauthors = Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP | title = Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons | journal = J. Virol. | volume = 76 | issue = 7 | pages = 3179–88 | year = 2002 | pmid = 11884542 | pmc = 136041 | doi = 10.1128/JVI.76.7.3179-3188.2002 }}
*{{cite journal | author=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399-407 |year= 2001 |pmid= 11299302 |doi= }}
* {{cite journal | vauthors = Ludwig MG, Seuwen K | title = Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms | journal = J. Recept. Signal Transduct. Res. | volume = 22 | issue = 1–4 | pages = 79–110 | year = 2003 | pmid = 12503609 | doi = 10.1081/RRS-120014589 }}
*{{cite journal | author=Côté M, Guillon G, Payet MD, Gallo-Payet N |title=Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 9 |pages= 4495-503 |year= 2001 |pmid= 11549699 |doi= }}
* {{cite journal | vauthors = Salim S, Sinnarajah S, Kehrl JH, Dessauer CW | title = Identification of RGS2 and type V adenylyl cyclase interaction sites | journal = J. Biol. Chem. | volume = 278 | issue = 18 | pages = 15842–9 | year = 2003 | pmid = 12604604 | doi = 10.1074/jbc.M210663200 }}
*{{cite journal | author=Speth C, Schabetsberger T, Mohsenipour I, ''et al.'' |title=Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179-88 |year= 2002 |pmid= 11884542 |doi= }}
* {{cite journal | vauthors = Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD | title = Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes | journal = Mol. Cell | volume = 23 | issue = 6 | pages = 925–31 | year = 2006 | pmid = 16973443 | doi = 10.1016/j.molcel.2006.07.025 }}
*{{cite journal | author=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1-4 |pages= 79-110 |year= 2003 |pmid= 12503609 |doi= }}
* {{cite journal | vauthors = Wang SC, Lai HL, Chiu YT, Ou R, Huang CL, Chern Y | title = Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor | journal = Biochem J | volume = 406 | issue = 3 | pages = 383–8 | year = 2007 | pmid = 17593019 | pmc = 2049038 | doi = 10.1042/BJ20070512 }}
*{{cite journal | author=Salim S, Sinnarajah S, Kehrl JH, Dessauer CW |title=Identification of RGS2 and type V adenylyl cyclase interaction sites. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 15842-9 |year= 2003 |pmid= 12604604 |doi= 10.1074/jbc.M210663200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Muzny DM, Scherer SE, Kaul R, ''et al.'' |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194-8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 }}
*{{cite journal  | author=Bauman AL, Soughayer J, Nguyen BT, ''et al.'' |title=Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. |journal=Mol. Cell |volume=23 |issue= 6 |pages= 925-31 |year= 2006 |pmid= 16973443 |doi= 10.1016/j.molcel.2006.07.025 }}
}}
{{refend}}
{{refend}}


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Revision as of 17:50, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene.[1][2]

Interactions

ADCY5 has been shown to interact with RGS2.[3]

References

  1. ↑ Raimundo S, Giray J, Volff JN, Schwab M, Altenbuchner J, Ratge D, Wisser H (October 1999). "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues". Clin Chim Acta. 285 (1–2): 155–61. doi:10.1016/S0009-8981(99)00067-4. PMID 10481931.
  2. ↑ "Entrez Gene: ADCY5 adenylate cyclase 5".
  3. ↑ Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (May 2003). "Identification of RGS2 and type V adenylyl cyclase interaction sites". J. Biol. Chem. 278 (18): 15842–9. doi:10.1074/jbc.M210663200. PMID 12604604.

External links

Further reading


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