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{{Infobox_gene}}
{{PBB_Controls
'''Adenylyl cyclase type 1''' is an [[enzyme]] that in humans is encoded by the ''ADCY1'' [[gene]].<ref name="pmid8314585">{{cite journal | vauthors = Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR | title = Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase | journal = Genomics | volume = 16 | issue = 2 | pages = 473–8 | date = May 1993 | pmid = 8314585 | pmc =  | doi = 10.1006/geno.1993.1213 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADCY1 adenylyl cyclase 1 (brain)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=107| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a form of adenylyl cyclase expressed in brain. A similar protein in mice is involved in pattern formation of the brain.<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Adenylate cyclase 1 (brain)
| HGNCid = 232
| Symbol = ADCY1
| AltSymbols =;
| OMIM = 103072
| ECnumber = 
| Homologene = 41419
| MGIid = 99677
| GeneAtlas_image1 = PBB_GE_ADCY1_215348_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0008294 |text = calcium- and calmodulin-responsive adenylate cyclase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006171 |text = cAMP biosynthetic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 107
    | Hs_Ensembl = ENSG00000164742
    | Hs_RefseqProtein = NP_066939
    | Hs_RefseqmRNA = NM_021116
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 45580646
    | Hs_GenLoc_end = 45729237
    | Hs_Uniprot = Q08828
    | Mm_EntrezGene = 432530
    | Mm_Ensembl = ENSMUSG00000020431
    | Mm_RefseqmRNA = NM_009622
    | Mm_RefseqProtein = NP_033752
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 6963492
    | Mm_GenLoc_end = 7078509
    | Mm_Uniprot = Q5DTQ1
  }}
}}
'''Adenylate cyclase 1 (brain)''', also known as '''ADCY1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADCY1 adenylate cyclase 1 (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=107| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Function ==
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain.<ref name="entrez">{{cite web | title = Entrez Gene: ADCY1 adenylate cyclase 1 (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=107| accessdate = }}</ref>
}}


==References==
ADCY1 is a calmodulin-sensitive [[adenylyl cyclase]]. In terms of function, It may be involved in regulatory processes in the central
{{reflist|2}}
nervous system; specifically, it may play a role in memory acquisition and learning. It is inhibited by the [[G protein]] beta and gamma subunit complex.<ref name="genecards">{{cite web | title = Gene Cards: ADCY1 Gene| url = http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADCY1| accessdate = 2012-12-30}}</ref>
==Further reading==
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|ADCY1}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Osawa S, Dhanasekaran N, Woon CW, Johnson GL | title = G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions | journal = Cell | volume = 63 | issue = 4 | pages = 697–706 | date = Nov 1990 | pmid = 2121366 | doi = 10.1016/0092-8674(90)90136-3 }}
| citations =
* {{cite journal | vauthors = Gaudin C, Homcy CJ, Ishikawa Y | title = Mammalian adenylyl cyclase family members are randomly located on different chromosomes | journal = Human Genetics | volume = 94 | issue = 5 | pages = 527–9 | date = Nov 1994 | pmid = 7959689 | doi = 10.1007/BF00211020 }}
*{{cite journal | author=Osawa S, Dhanasekaran N, Woon CW, Johnson GL |title=G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions. |journal=Cell |volume=63 |issue= 4 |pages= 697-706 |year= 1990 |pmid= 2121366 |doi= }}
* {{cite journal | vauthors = Whisnant RE, Gilman AG, Dessauer CW | title = Interaction of the two cytosolic domains of mammalian adenylyl cyclase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 13 | pages = 6621–5 | date = Jun 1996 | pmid = 8692867 | pmc = 39075 | doi = 10.1073/pnas.93.13.6621 }}
*{{cite journal | author=Gaudin C, Homcy CJ, Ishikawa Y |title=Mammalian adenylyl cyclase family members are randomly located on different chromosomes. |journal=Hum. Genet. |volume=94 |issue= 5 |pages= 527-9 |year= 1994 |pmid= 7959689 |doi=  }}
* {{cite journal | vauthors = Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP | title = Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1 | journal = Pflügers Archiv | volume = 437 | issue = 4 | pages = 538–46 | date = Mar 1999 | pmid = 10089566 | doi = 10.1007/s004240050815 }}
*{{cite journal  | author=Villacres EC, Xia Z, Bookbinder LH, ''et al.'' |title=Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase. |journal=Genomics |volume=16 |issue= 2 |pages= 473-8 |year= 1993 |pmid= 8314585 |doi= 10.1006/geno.1993.1213 }}
* {{cite journal | vauthors = Speth C, Joebstl B, Barcova M, Dierich MP | title = HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones | journal = AIDS | volume = 14 | issue = 6 | pages = 629–36 | date = Apr 2000 | pmid = 10807185 | doi = 10.1097/00002030-200004140-00001 }}
*{{cite journal | author=Whisnant RE, Gilman AG, Dessauer CW |title=Interaction of the two cytosolic domains of mammalian adenylyl cyclase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6621-5 |year= 1996 |pmid= 8692867 |doi= }}
* {{cite journal | vauthors = Patke CL, Shearer WT | title = gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression | journal = The Journal of Allergy and Clinical Immunology | volume = 105 | issue = 5 | pages = 975–82 | date = May 2000 | pmid = 10808179 | doi = 10.1067/mai.2000.105315 }}
*{{cite journal | author=Barcova M, Speth C, Kacani L, ''et al.'' |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflugers Arch. |volume=437 |issue= 4 |pages= 538-46 |year= 1999 |pmid= 10089566 |doi= }}
* {{cite journal | vauthors = Patrizio M, Colucci M, Levi G | title = Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures | journal = Journal of Neurochemistry | volume = 77 | issue = 2 | pages = 399–407 | date = Apr 2001 | pmid = 11299302 | doi = 10.1046/j.1471-4159.2001.00249.x }}
*{{cite journal | author=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629-36 |year= 2000 |pmid= 10807185 |doi= }}
* {{cite journal | vauthors = Côté M, Guillon G, Payet MD, Gallo-Payet N | title = Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 86 | issue = 9 | pages = 4495–503 | date = Sep 2001 | pmid = 11549699 | doi = 10.1210/jc.86.9.4495 }}
*{{cite journal | author=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975-82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
* {{cite journal | vauthors = Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP | title = Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons | journal = Journal of Virology | volume = 76 | issue = 7 | pages = 3179–88 | date = Apr 2002 | pmid = 11884542 | pmc = 136041 | doi = 10.1128/JVI.76.7.3179-3188.2002 }}
*{{cite journal | author=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399-407 |year= 2001 |pmid= 11299302 |doi= }}
* {{cite journal | vauthors = Ludwig MG, Seuwen K | title = Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms | journal = Journal of Receptor and Signal Transduction Research | volume = 22 | issue = 1-4 | pages = 79–110 | year = 2003 | pmid = 12503609 | doi = 10.1081/RRS-120014589 }}
*{{cite journal | author=Côté M, Guillon G, Payet MD, Gallo-Payet N |title=Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 9 |pages= 4495-503 |year= 2001 |pmid= 11549699 |doi= }}
* {{cite journal | vauthors = Tucholski J, Johnson GV | title = Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26838–43 | date = Jul 2003 | pmid = 12743114 | doi = 10.1074/jbc.M303683200 }}
*{{cite journal | author=Speth C, Schabetsberger T, Mohsenipour I, ''et al.'' |title=Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179-88 |year= 2002 |pmid= 11884542 |doi= }}
* {{cite journal | vauthors = Wang H, Ferguson GD, Pineda VV, Cundiff PE, Storm DR | title = Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP | journal = Nature Neuroscience | volume = 7 | issue = 6 | pages = 635–42 | date = Jun 2004 | pmid = 15133516 | doi = 10.1038/nn1248 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Vortherms TA, Nguyen CH, Berlot CH, Watts VJ | title = Using molecular tools to dissect the role of Galphas in sensitization of AC1 | journal = Molecular Pharmacology | volume = 66 | issue = 6 | pages = 1617–24 | date = Dec 2004 | pmid = 15361543 | doi = 10.1124/mol.104.000166 }}
*{{cite journal | author=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1-4 |pages= 79-110 |year= 2003 |pmid= 12503609 |doi=  }}
* {{cite journal | vauthors = Weber B, Schaper C, Scholz J, Bein B, Rodde C, H Tonner P | title = Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase | journal = Cellular Signalling | volume = 18 | issue = 10 | pages = 1748–57 | date = Oct 2006 | pmid = 16531006 | doi = 10.1016/j.cellsig.2006.01.017 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
* {{cite journal | vauthors = Nlend MC, Schmid A, Sutto Z, Ransford GA, Conner GE, Fregien N, Salathe M | title = Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia | journal = FEBS Letters | volume = 581 | issue = 17 | pages = 3241–6 | date = Jul 2007 | pmid = 17586501 | pmc = 1986749 | doi = 10.1016/j.febslet.2007.06.015 }}
*{{cite journal | author=Tucholski J, Johnson GV |title=Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26838-43 |year= 2003 |pmid= 12743114 |doi= 10.1074/jbc.M303683200 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Wang H, Ferguson GD, Pineda VV, ''et al.'' |title=Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP. |journal=Nat. Neurosci. |volume=7 |issue= 6 |pages= 635-42 |year= 2004 |pmid= 15133516 |doi= 10.1038/nn1248 }}
*{{cite journal | author=Vortherms TA, Nguyen CH, Berlot CH, Watts VJ |title=Using molecular tools to dissect the role of Galphas in sensitization of AC1. |journal=Mol. Pharmacol. |volume=66 |issue= 6 |pages= 1617-24 |year= 2005 |pmid= 15361543 |doi= 10.1124/mol.104.000166 }}
*{{cite journal | author=Weber B, Schaper C, Scholz J, ''et al.'' |title=Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase. |journal=Cell. Signal. |volume=18 |issue= 10 |pages= 1748-57 |year= 2006 |pmid= 16531006 |doi= 10.1016/j.cellsig.2006.01.017 }}
*{{cite journal | author=Nlend MC, Schmid A, Sutto Z, ''et al.'' |title=Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia. |journal=FEBS Lett. |volume=581 |issue= 17 |pages= 3241-6 |year= 2007 |pmid= 17586501 |doi= 10.1016/j.febslet.2007.06.015 }}
}}
{{refend}}
{{refend}}


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Revision as of 17:50, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.[1][2]

This gene encodes a form of adenylyl cyclase expressed in brain. A similar protein in mice is involved in pattern formation of the brain.[2]

Function

ADCY1 is a calmodulin-sensitive adenylyl cyclase. In terms of function, It may be involved in regulatory processes in the central nervous system; specifically, it may play a role in memory acquisition and learning. It is inhibited by the G protein beta and gamma subunit complex.[3]

References

  1. ↑ Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR (May 1993). "Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase". Genomics. 16 (2): 473–8. doi:10.1006/geno.1993.1213. PMID 8314585.
  2. ↑ 2.0 2.1 "Entrez Gene: ADCY1 adenylyl cyclase 1 (brain)".
  3. ↑ "Gene Cards: ADCY1 Gene". Retrieved 2012-12-30.

External links

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=ADCY1&oldid=1421741"