ADAMTS5

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ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)
Identifiers
SymbolADAMTS5
Entrez11096
HUGO221
OMIM605007
RefSeqNM_007038
UniProtQ9UNA0
Other data
LocusChr. 21 q22.1-q22

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Overview

ADAMTS5 (aggrecanase) is an enzyme that destroys cartilage in mice. Its discovery may lead to progress in human arthritis research. This enzyme may also be involved in cartilage deterioration in humans. It has been isolated and identified by Australian scientists in Sydney. ADAMTS5 has been indicated as being important in early osteoarthritis.

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