ACSL1

Acyl-CoA synthetase long-chain family member 1
Identifiers
Symbols	ACSL1 ; ACS1; FACL1; FACL2; LACS; LACS1; LACS2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37561
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Acyl-CoA synthetase long-chain family member 1, also known as ACSL1, is a human gene.

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.

Further reading

• Stanczak H, Stanczak JJ, Singh I (1992). "Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1)". Cytogenet. Cell Genet. 59 (1): 17–9. PMID 1531127.CS1 maint: Multiple names: authors list (link)
• Amigo L, McElroy MC, Morales MN, Bronfman M (1992). "Subcellular distribution and characteristics of ciprofibroyl-CoA synthetase in rat liver. Its possible identity with long-chain acyl-CoA synthetase". Biochem. J. 284 ( Pt 1): 283–7. PMID 1599407.CS1 maint: Multiple names: authors list (link)
• Abe T, Fujino T, Fukuyama R; et al. (1992). "Human long-chain acyl-CoA synthetase: structure and chromosomal location". J. Biochem. 111 (1): 123–8. PMID 1607358.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lageweg W, Wanders RJ, Tager JM (1991). "Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study". Eur. J. Biochem. 196 (2): 519–23. PMID 2007410.CS1 maint: Multiple names: authors list (link)
• Suzuki H, Kawarabayasi Y, Kondo J; et al. (1990). "Structure and regulation of rat long-chain acyl-CoA synthetase". J. Biol. Chem. 265 (15): 8681–5. PMID 2341402.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Singh I, Bhushan A, Relan NK, Hashimoto T (1989). "Acyl-CoA ligases from rat brain microsomes: an immunochemical study". Biochim. Biophys. Acta. 963 (3): 509–14. PMID 2973813.CS1 maint: Multiple names: authors list (link)
• Bierbach H (1981). "Studies on long chain fatty acid:CoA ligase from human small intestine". Gut. 21 (8): 689–94. PMID 7429333.
• Cantú ES, Sprinkle TJ, Ghosh B, Singh I (1996). "The human palmitoyl-CoA ligase (FACL2) gene maps to the chromosome 4q34-q35 region by fluorescence in situ hybridization (FISH) and somatic cell hybrid panels". Genomics. 28 (3): 600–2. doi:10.1006/geno.1995.1199. PMID 7490105.CS1 maint: Multiple names: authors list (link)
• Wu P, Bremer J (1994). "Activation of alkylthioacrylic acids in subcellular fractions of rat tissues: a new spectrophotometric method for assay of acyl-CoA synthetase". Biochim. Biophys. Acta. 1215 (1–2): 87–92. PMID 7948012.
• Singh I, Lazo O, Kremser K (1993). "Purification of peroxisomes and subcellular distribution of enzyme activities for activation and oxidation of very-long-chain fatty acids in rat brain". Biochim. Biophys. Acta. 1170 (1): 44–52. PMID 8399326.CS1 maint: Multiple names: authors list (link)
• Ghosh B, Barbosa E, Singh I (1996). "Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression". Mol. Cell. Biochem. 151 (1): 77–81. PMID 8584017.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (2000). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors". Biochem. J. 344 Pt 1: 135–43. PMID 10548543.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mashek DG, Bornfeldt KE, Coleman RA; et al. (2005). "Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family". J. Lipid Res. 45 (10): 1958–61. doi:10.1194/jlr.E400002-JLR200. PMID 15292367.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soupene E, Kuypers FA (2006). "Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains". BMC Mol. Biol. 7: 21. doi:10.1186/1471-2199-7-21. PMID 16834775.