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Acyl-CoA synthetase long-chain family member 1
External IDs OMIM: 152425 MGI102797 Homologene37561
RNA expression pattern

PBB GE ACSL1 201963 at tn.png

PBB GE ACSL1 207275 s at tn.png

More reference expression data

Human Mouse
Entrez 2180 14081
Ensembl ENSG00000151726 ENSMUSG00000018796
Uniprot P33121 Q6GTG6
Refseq NM_001995 (mRNA)
NP_001986 (protein)
XM_991183 (mRNA)
XP_996277 (protein)
Location Chr 4: 185.91 - 185.98 Mb Chr 8: 47.97 - 48.03 Mb
Pubmed search [1] [2]

Acyl-CoA synthetase long-chain family member 1, also known as ACSL1, is a human gene.[1]

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.[1]


Further reading

  • Stanczak H, Stanczak JJ, Singh I (1992). "Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1).". Cytogenet. Cell Genet. 59 (1): 17–9. PMID 1531127. 
  • Amigo L, McElroy MC, Morales MN, Bronfman M (1992). "Subcellular distribution and characteristics of ciprofibroyl-CoA synthetase in rat liver. Its possible identity with long-chain acyl-CoA synthetase.". Biochem. J. 284 ( Pt 1): 283–7. PMID 1599407. 
  • Abe T, Fujino T, Fukuyama R; et al. (1992). "Human long-chain acyl-CoA synthetase: structure and chromosomal location.". J. Biochem. 111 (1): 123–8. PMID 1607358. 
  • Lageweg W, Wanders RJ, Tager JM (1991). "Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study.". Eur. J. Biochem. 196 (2): 519–23. PMID 2007410. 
  • Suzuki H, Kawarabayasi Y, Kondo J; et al. (1990). "Structure and regulation of rat long-chain acyl-CoA synthetase.". J. Biol. Chem. 265 (15): 8681–5. PMID 2341402. 
  • Singh I, Bhushan A, Relan NK, Hashimoto T (1989). "Acyl-CoA ligases from rat brain microsomes: an immunochemical study.". Biochim. Biophys. Acta. 963 (3): 509–14. PMID 2973813. 
  • Bierbach H (1981). "Studies on long chain fatty acid:CoA ligase from human small intestine.". Gut. 21 (8): 689–94. PMID 7429333. 
  • Cantú ES, Sprinkle TJ, Ghosh B, Singh I (1996). "The human palmitoyl-CoA ligase (FACL2) gene maps to the chromosome 4q34-q35 region by fluorescence in situ hybridization (FISH) and somatic cell hybrid panels.". Genomics. 28 (3): 600–2. PMID 7490105. doi:10.1006/geno.1995.1199. 
  • Wu P, Bremer J (1994). "Activation of alkylthioacrylic acids in subcellular fractions of rat tissues: a new spectrophotometric method for assay of acyl-CoA synthetase.". Biochim. Biophys. Acta. 1215 (1-2): 87–92. PMID 7948012. 
  • Singh I, Lazo O, Kremser K (1993). "Purification of peroxisomes and subcellular distribution of enzyme activities for activation and oxidation of very-long-chain fatty acids in rat brain.". Biochim. Biophys. Acta. 1170 (1): 44–52. PMID 8399326. 
  • Ghosh B, Barbosa E, Singh I (1996). "Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression.". Mol. Cell. Biochem. 151 (1): 77–81. PMID 8584017. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (2000). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors.". Biochem. J. 344 Pt 1: 135–43. PMID 10548543. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Mashek DG, Bornfeldt KE, Coleman RA; et al. (2005). "Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.". J. Lipid Res. 45 (10): 1958–61. PMID 15292367. doi:10.1194/jlr.E400002-JLR200. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Soupene E, Kuypers FA (2006). "Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains.". BMC Mol. Biol. 7: 21. PMID 16834775. doi:10.1186/1471-2199-7-21.