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{{Infobox_gene}}
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'''Abl interactor 2''' also known as '''Abelson interactor 2''' (Abi-2) is a [[protein]] that in humans is encoded by the ''ABI2'' [[gene]].<ref name="pmid7590236">{{cite journal |vauthors=Dai Z, Pendergast AM | title = Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity | journal = Genes Dev | volume = 9 | issue = 21 | pages = 2569–82 |date=Dec 1995 | pmid = 7590236 | pmc =  | doi =10.1101/gad.9.21.2569  }}</ref><ref name="pmid10964520">{{cite journal |vauthors=Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC | title = A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium | journal = Genomics | volume = 68 | issue = 2 | pages = 220–8 |date=Sep 2000 | pmid = 10964520 | pmc =  | doi = 10.1006/geno.2000.6291 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ABI2 abl interactor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10152| accessdate = }}</ref>
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==Interactions==
{{GNF_Protein_box
ABI2 has been shown to [[Protein-protein interaction|interact]] with [[Abl gene|ABL1]],<ref name="pmid7590236"/><ref name="pmid12569093">{{cite journal |vauthors=Cao C, Leng Y, Li C, Kufe D | title = Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response | journal = J. Biol. Chem. | volume = 278 | issue = 15 | pages = 12961–7 |date=April 2003 | pmid = 12569093 | doi = 10.1074/jbc.M300058200 | url =  }}</ref>[[ADAM19]],<ref name="pmid12463424">{{cite journal |vauthors=Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C | title = Screen and identification of proteins interacting with ADAM19 cytoplasmic tail | journal = Mol. Biol. Rep. | volume = 29 | issue = 3 | pages = 317–23 |date=September 2002 | pmid = 12463424 | doi = 10.1023/A:1020409217215| url =  }}</ref> and [[TRIM32]].<ref name="pmid18632609">{{cite journal |vauthors=Kano S, Miyajima N, Fukuda S, Hatakeyama S | title = Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2 | journal = Cancer Res. | volume = 68 | issue = 14 | pages = 5572–80 |date=July 2008 | pmid = 18632609 | doi = 10.1158/0008-5472.CAN-07-6231 | url = }}</ref>
| image = 
| image_source =
| PDB =  
| Name = Abl interactor 2
| HGNCid = 24011
| Symbol = ABI2
| AltSymbols =; ABI-2; ABI2B; AIP-1; AblBP3; SSH3BP2; argBPIA; argBPIB
  | OMIM = 606442
| ECnumber =
| Homologene = 4209
| MGIid = 106913
| GeneAtlas_image1 = PBB_GE_ABI2_211793_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ABI2_207268_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ABI2_209856_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0008093 |text = cytoskeletal adaptor activity}} {{GNF_GO|id=GO:0017124 |text = SH3 domain binding}} {{GNF_GO|id=GO:0019900 |text = kinase binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005913 |text = cell-cell adherens junction}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}} {{GNF_GO|id=GO:0030175 |text = filopodium}} {{GNF_GO|id=GO:0030425 |text = dendrite}}
  | Process = {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008154 |text = actin polymerization and/or depolymerization}} {{GNF_GO|id=GO:0016358 |text = dendrite development}} {{GNF_GO|id=GO:0016477 |text = cell migration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10152
    | Hs_Ensembl = ENSG00000138443
    | Hs_RefseqProtein = XP_001126750
    | Hs_RefseqmRNA = XM_001126750
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 203901401
    | Hs_GenLoc_end = 204000576
    | Hs_Uniprot = Q9NYB9
    | Mm_EntrezGene = 329165
    | Mm_Ensembl = ENSMUSG00000026782
    | Mm_RefseqmRNA = NM_198127
    | Mm_RefseqProtein = NP_937760
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 60354280
    | Mm_GenLoc_end = 60425704
    | Mm_Uniprot = Q3UVN6
  }}
}}
'''Abl interactor 2''', also known as '''ABI2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABI2 abl interactor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10152| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{Reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin| 2}}
{{PBB_Further_reading
*{{Cite journal  |vauthors=Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S |title=In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review). |journal=Int. J. Mol. Med. |volume=9 |issue= 6 |pages= 591–5 |year= 2002 |pmid= 12011975 |doi=  10.3892/ijmm.9.6.591}}
| citations =
*{{Cite journal  |vauthors=Wang B, Mysliwiec T, Krainc D |title=Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. |journal=Oncogene |volume=12 |issue= 9 |pages= 1921–9 |year= 1996 |pmid= 8649853 |doi=  |display-authors=etal}}
*{{cite journal  | author=Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S |title=In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review). |journal=Int. J. Mol. Med. |volume=9 |issue= 6 |pages= 591-5 |year= 2002 |pmid= 12011975 |doi=  }}
*{{Cite journal  |vauthors=Juang JL, Hoffmann FM |title=Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. |journal=Oncogene |volume=18 |issue= 37 |pages= 5138–47 |year= 1999 |pmid= 10498863 |doi= 10.1038/sj.onc.1202911 }}
*{{cite journal  | author=Dai Z, Pendergast AM |title=Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2569-82 |year= 1995 |pmid= 7590236 |doi=  }}
*{{Cite journal  |vauthors=Chen B, Borinstein SC, Gillis J |title=The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 19275–81 |year= 2000 |pmid= 10858458 |doi= 10.1074/jbc.M908994199 |display-authors=etal}}
*{{cite journal  | author=Wang B, Mysliwiec T, Krainc D, ''et al.'' |title=Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. |journal=Oncogene |volume=12 |issue= 9 |pages= 1921-9 |year= 1996 |pmid= 8649853 |doi= }}
*{{Cite journal  |vauthors=Machado RD, Pauciulo MW, Fretwell N |title=A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium. |journal=Genomics |volume=68 |issue= 2 |pages= 220–8 |year= 2001 |pmid= 10964520 |doi= 10.1006/geno.2000.6291 |display-authors=etal}}
*{{cite journal  | author=Juang JL, Hoffmann FM |title=Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. |journal=Oncogene |volume=18 |issue= 37 |pages= 5138-47 |year= 1999 |pmid= 10498863 |doi= 10.1038/sj.onc.1202911 }}
*{{Cite journal  |vauthors=Courtney KD, Grove M, Vandongen H |title=Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system. |journal=Mol. Cell. Neurosci. |volume=16 |issue= 3 |pages= 244–57 |year= 2000 |pmid= 10995551 |doi= 10.1006/mcne.2000.0865 |display-authors=etal}}
*{{cite journal  | author=Chen B, Borinstein SC, Gillis J, ''et al.'' |title=The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 19275-81 |year= 2000 |pmid= 10858458 |doi= 10.1074/jbc.M908994199 }}
*{{Cite journal  |vauthors=Stradal T, Courtney KD, Rottner K |title=The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. |journal=Curr. Biol. |volume=11 |issue= 11 |pages= 891–5 |year= 2001 |pmid= 11516653 |doi=10.1016/S0960-9822(01)00239-1  |display-authors=etal}}
*{{cite journal  | author=Machado RD, Pauciulo MW, Fretwell N, ''et al.'' |title=A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium. |journal=Genomics |volume=68 |issue= 2 |pages= 220-8 |year= 2001 |pmid= 10964520 |doi= 10.1006/geno.2000.6291 }}
*{{Cite journal  |vauthors=Huang L, Feng L, Yang L |title=Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. |journal=Mol. Biol. Rep. |volume=29 |issue= 3 |pages= 317–23 |year= 2003 |pmid= 12463424 |doi=10.1023/A:1020409217215 |display-authors=etal}}
*{{cite journal  | author=Courtney KD, Grove M, Vandongen H, ''et al.'' |title=Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system. |journal=Mol. Cell. Neurosci. |volume=16 |issue= 3 |pages= 244-57 |year= 2000 |pmid= 10995551 |doi= 10.1006/mcne.2000.0865 }}
*{{Cite journal | author = Mammalian Gene Collection Program Team | display-authors = 4 | last2 = Strausberg | first2 = R. L. | last3 = Feingold | first3 = E. A. | last4 = Grouse | first4 = L. H. | last5 = Derge | first5 = J. G. | last6 = Klausner | first6 = R. D. | last7 = Collins | first7 = F. S. | last8 = Wagner | first8 = L. | last9 = Shenmen | first9 = C. M. | last10 = Schuler | first10 = G. D. | doi = 10.1073/pnas.242603899 | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = [[Proceedings of the National Academy of Sciences of the United States of America|Proceedings of the National Academy of Sciences]] | volume = 99 | issue = 26 | pages = 16899–16903 | pmc = 139241 | year = 2002 | pmid = 12477932}}
*{{cite journal  | author=Stradal T, Courtney KD, Rottner K, ''et al.'' |title=The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. |journal=Curr. Biol. |volume=11 |issue= 11 |pages= 891-5 |year= 2001 |pmid= 11516653 |doi=  }}
*{{Cite journal  |vauthors=Cao C, Leng Y, Li C, Kufe D |title=Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 12961–7 |year= 2003 |pmid= 12569093 |doi= 10.1074/jbc.M300058200 }}
*{{cite journal | author=Huang L, Feng L, Yang L, ''et al.'' |title=Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. |journal=Mol. Biol. Rep. |volume=29 |issue= 3 |pages= 317-23 |year= 2003 |pmid= 12463424 |doi= }}
*{{Cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{Cite journal  |vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |display-authors=etal}}
*{{cite journal  | author=Cao C, Leng Y, Li C, Kufe D |title=Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response. |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 12961-7 |year= 2003 |pmid= 12569093 |doi= 10.1074/jbc.M300058200 }}
*{{Cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{Cite journal  |vauthors=Eastman SW, Martin-Serrano J, Chung W |title=Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding |journal=J. Biol. Chem. |volume=280 |issue= 1 |pages= 628–36 |year= 2005 |pmid= 15509564 |doi= 10.1074/jbc.M410384200 |display-authors=etal}}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{Cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{Cite journal  |vauthors=Luo X, Levens E, Williams RS, Chegini N |title=The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta |journal=Hum. Reprod. |volume=21 |issue= 6 |pages= 1380–6 |year= 2006 |pmid= 16488906 |doi= 10.1093/humrep/del011 }}
*{{cite journal  | author=Eastman SW, Martin-Serrano J, Chung W, ''et al.'' |title=Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. |journal=J. Biol. Chem. |volume=280 |issue= 1 |pages= 628-36 |year= 2005 |pmid= 15509564 |doi= 10.1074/jbc.M410384200 }}
*{{Cite journal  |vauthors=Hirao N, Sato S, Gotoh T |title=NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation |journal=FEBS Lett. |volume=580 |issue= 27 |pages= 6464–70 |year= 2007 |pmid= 17101133 |doi= 10.1016/j.febslet.2006.10.065 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{Cite journal  |vauthors=Li Y, Clough N, Sun X |title=BCR-ABL Induces Abnormal Cytoskeleton Remodeling, β1 Integrin Clustering, and Increased Cell Adhesion to Fibronectin Through ABL Interactor 1 Pathway |journal=J. Cell Sci. |volume=120 |issue= Pt 8 |pages= 1436–46 |year= 2007 |pmid= 17389688 |doi= 10.1242/jcs.03430  | pmc=1950936 |display-authors=etal}}
*{{cite journal  | author=Luo X, Levens E, Williams RS, Chegini N |title=The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta. |journal=Hum. Reprod. |volume=21 |issue= 6 |pages= 1380-6 |year= 2006 |pmid= 16488906 |doi= 10.1093/humrep/del011 }}
{{Refend}}
*{{cite journal  | author=Hirao N, Sato S, Gotoh T, ''et al.'' |title=NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. |journal=FEBS Lett. |volume=580 |issue= 27 |pages= 6464-70 |year= 2007 |pmid= 17101133 |doi= 10.1016/j.febslet.2006.10.065 }}
 
*{{cite journal  | author=Li Y, Clough N, Sun X, ''et al.'' |title=Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway. |journal=J. Cell. Sci. |volume=120 |issue= Pt 8 |pages= 1436-46 |year= 2007 |pmid= 17389688 |doi= 10.1242/jcs.03430 }}
==External links==
}}
* {{UCSC genome browser|ABI2}}
{{refend}}
* {{UCSC gene details|ABI2}}
 
{{DEFAULTSORT:Abi2}}
 


{{protein-stub}}
{{Gene-2-stub}}
{{WikiDoc Sources}}

Latest revision as of 19:14, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene.[1][2][3]

Interactions

ABI2 has been shown to interact with ABL1,[1][4]ADAM19,[5] and TRIM32.[6]

References

  1. ↑ 1.0 1.1 Dai Z, Pendergast AM (Dec 1995). "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity". Genes Dev. 9 (21): 2569–82. doi:10.1101/gad.9.21.2569. PMID 7590236.
  2. ↑ Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (Sep 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
  3. ↑ "Entrez Gene: ABI2 abl interactor 2".
  4. ↑ Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
  5. ↑ Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (September 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424.
  6. ↑ Kano S, Miyajima N, Fukuda S, Hatakeyama S (July 2008). "Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2". Cancer Res. 68 (14): 5572–80. doi:10.1158/0008-5472.CAN-07-6231. PMID 18632609.

Further reading

External links



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