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Abl interactor 2
Symbol(s) ABI2; ABI-2; ABI2B; AIP-1; AblBP3; SSH3BP2; argBPIA; argBPIB
External IDs OMIM: 606442 MGI106913 Homologene4209
RNA expression pattern

PBB GE ABI2 211793 s at tn.png

PBB GE ABI2 207268 x at tn.png

PBB GE ABI2 209856 x at tn.png

More reference expression data

Human Mouse
Entrez 10152 329165
Ensembl ENSG00000138443 ENSMUSG00000026782
Uniprot Q9NYB9 Q3UVN6
Refseq XM_001126750 (mRNA)
XP_001126750 (protein)
NM_198127 (mRNA)
NP_937760 (protein)
Location Chr 2: 203.9 - 204 Mb Chr 1: 60.35 - 60.43 Mb
Pubmed search [1] [2]

Abl interactor 2, also known as ABI2, is a human gene.[1]


Further reading

  • Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review).". Int. J. Mol. Med. 9 (6): 591–5. PMID 12011975. 
  • Dai Z, Pendergast AM (1995). "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.". Genes Dev. 9 (21): 2569–82. PMID 7590236. 
  • Wang B, Mysliwiec T, Krainc D; et al. (1996). "Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene.". Oncogene. 12 (9): 1921–9. PMID 8649853. 
  • Juang JL, Hoffmann FM (1999). "Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity.". Oncogene. 18 (37): 5138–47. PMID 10498863. doi:10.1038/sj.onc.1202911. 
  • Chen B, Borinstein SC, Gillis J; et al. (2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes.". J. Biol. Chem. 275 (25): 19275–81. PMID 10858458. doi:10.1074/jbc.M908994199. 
  • Machado RD, Pauciulo MW, Fretwell N; et al. (2001). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium.". Genomics. 68 (2): 220–8. PMID 10964520. doi:10.1006/geno.2000.6291. 
  • Courtney KD, Grove M, Vandongen H; et al. (2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.". Mol. Cell. Neurosci. 16 (3): 244–57. PMID 10995551. doi:10.1006/mcne.2000.0865. 
  • Stradal T, Courtney KD, Rottner K; et al. (2001). "The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.". Curr. Biol. 11 (11): 891–5. PMID 11516653. 
  • Huang L, Feng L, Yang L; et al. (2003). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.". Mol. Biol. Rep. 29 (3): 317–23. PMID 12463424. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Cao C, Leng Y, Li C, Kufe D (2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response.". J. Biol. Chem. 278 (15): 12961–7. PMID 12569093. doi:10.1074/jbc.M300058200. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. PMID 15146197. doi:10.1038/nbt971. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Eastman SW, Martin-Serrano J, Chung W; et al. (2005). "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.". J. Biol. Chem. 280 (1): 628–36. PMID 15509564. doi:10.1074/jbc.M410384200. 
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  • Luo X, Levens E, Williams RS, Chegini N (2006). "The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta.". Hum. Reprod. 21 (6): 1380–6. PMID 16488906. doi:10.1093/humrep/del011. 
  • Hirao N, Sato S, Gotoh T; et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.". FEBS Lett. 580 (27): 6464–70. PMID 17101133. doi:10.1016/j.febslet.2006.10.065. 
  • Li Y, Clough N, Sun X; et al. (2007). "Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway.". J. Cell. Sci. 120 (Pt 8): 1436–46. PMID 17389688. doi:10.1242/jcs.03430.