Anemia of prematurity medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Asra Firdous, M.B.B.S.[2]

Overview

PRBC transfusion is the mainstay in the treatment of anemia of prematurity.Treatment of infants with anemia of prematurity depends on the severity of symptoms. Blood transfusion and recombinant erythropoietin therapy are used to treat symptomatic infants


Medical therapy

The optimal therapy for anemia of prematurity depends on the severity of symptoms. Patients with asymptomatic anemia of prematurity require observation and supportive care, whereas symptomatic patients are treated either with blood transfusion or recombinant erythropoietin (EPO) therapy. [1]

Asymptomatic patients

Symptomatic patients

Blood transfusion is the mainstay in the treatment of infants with symptomatic anemia of prematurity. Exogenous recombinant human erythropoietin can also be used.[2][3]

Erythropoietin

Complications

Complications associated with erythropoietin therapy are minimal in preterm infants. Following complications have been documented in adult patients treated with recombinant erythropoietin therapy.

Blood Transfusion

Complications

Significant infectious, hematologic, immunologic, metabolic complications are associated with blood transfusion in infants so standard protocols should be followed. Complications associated with blood transfusion are:

References

  1. "www.cancertherapyadvisor.com".
  2. Strauss RG (2010). "Anaemia of prematurity: pathophysiology and treatment". Blood Rev. 24 (6): 221–5. doi:10.1016/j.blre.2010.08.001. PMC 2981681. PMID 20817366.
  3. "www.cancertherapyadvisor.com".

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