Mercury (element)

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80 gold ← mercury → thallium Cd ↑ Hg ↓ Uub Image:Hg-TableImage.png Periodic Table - Extended Periodic Table
General
Name, Symbol, Number	mercury, Hg, 80
Chemical series	transition metals
Group, Period, Block	12, 6, d
Appearance	silvery
Standard atomic weight	200.59(2)  g·mol−1
Electron configuration	[Xe] 4f14 5d10 6s2
Electrons per shell	2, 8, 18, 32, 18, 2
Physical properties
Phase	liquid
Density (near r.t.)	(liquid) 13.534  g·cm−3
Melting point	234.32 K (-38.83 °C, -37.89 °F)
Boiling point	629.88 K (356.73 °C, 674.11 °F)
Critical point	1750 K, 172.00 MPa
Heat of fusion	2.29  kJ·mol−1
Heat of vaporization	59.11  kJ·mol−1
Heat capacity	(25 °C) 27.983  J·mol−1·K−1
Vapor pressure P(Pa) 1 10 100 1 k 10 k 100 k at T(K) 315 350 393 449 523 629
Atomic properties
Crystal structure	rhombohedral
Oxidation states	2 (mercuric), 1 (mercurous) (mildly basic oxide)
Electronegativity	2.00 (scale Pauling)
Ionization energies	1st: 1007.1 kJ/mol
	2nd: 1810 kJ/mol
	3rd: 3300 kJ/mol
Atomic radius	150  pm
Atomic radius (calc.)	171  pm
Covalent radius	149  pm
Van der Waals radius	155 pm
Miscellaneous
Magnetic ordering	diamagnetic
Electrical resistivity	(25 °C) 961 nΩ·m
Thermal conductivity	(300 K) 8.30  W·m−1·K−1
Thermal expansion	(25 °C) 60.4  µm·m−1·K−1
Speed of sound	(liquid, 20 °C) 1451.4 m/s
CAS registry number	7439-97-6
Selected isotopes
iso NA half-life DM DE (MeV) DP 194Hg syn 444 y ε 0.040 194Au 195Hg syn 9.9 h ε 1.510 195Au 196Hg 0.15% Hg is stable with 116 neutrons 197Hg syn 64.14 h ε 0.600 197Au 198Hg 9.97% Hg is stable with 118 neutrons 199Hg 16.87% Hg is stable with 119 neutrons 200Hg 23.1% Hg is stable with 120 neutrons 201Hg 13.18% Hg is stable with 121 neutrons 202Hg 29.86% Hg is stable with 122 neutrons 203Hg syn 46.612 d β- 0.492 203Tl 204Hg 6.87% Hg is stable with 124 neutrons
References

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Overview

Mercury(IPA: /ˈmɜrkjʊri/), also called quicksilver, is a chemical element with the symbol Hg (Latinized hydrargyrum, meaning watery or liquid silver) and atomic number 80. A heavy, silvery d-block metal, mercury is one of five elements that are liquid at or near room temperature and pressure.^[1] The others are the metals caesium, francium, and gallium, and the non-metal bromine. Of these, only mercury and bromine are liquids at standard conditions for temperature and pressure.

Mercury is used in thermometers, barometers, manometers, sphygmomanometers, float valves, and other scientific apparatus, though concerns about the element's toxicity have led to mercury thermometers and sphygmomanometers being largely phased out in clinical environments in favour of alcohol-filled, digital, or thermistor-based instruments. It remains in use in a number of other ways in scientific and scientific research applications, and in dental amalgam. Mercury is mostly obtained by reduction from the mineral cinnabar.

Mercury occurs in deposits throughout the world and it is harmless in an insoluble form, such as mercuric sulfide, but it is poisonous in soluble forms such as mercuric chloride or methylmercury.

Applications

Mercury is used primarily for the manufacture of industrial chemicals or for electrical and electronic applications. It is used in some thermometers, especially ones which are used to measure high temperatures (In the United States, non-prescription sale of mercury fever thermometers is banned by a number of different states and localities). Other uses:

• Mercury is still used in some cultures for folk medicine and ceremonial purposes which may involve ingestion, injection, or the sprinkling of elemental mercury around the home. It must be emphasized that the former two procedures, especially, are extremely

Historical uses: Mercury compounds have been used in antiseptics, laxatives, antidepressants, and in antisyphilitics.

Dentistry

The element mercury is the main ingredient in dental amalgams. Controversy over the health effects from the use of mercury amalgams began shortly after its introduction into the western world, nearly 200 years ago. In 1845, The American Society of Dental Surgeons, concerned about mercury poisoning, asked its members to sign a pledge that they would not use amalgam. The ASDS disbanded in 1865. The American Dental Association formed three years after and currently takes the position that "amalgam is a valuable, viable and safe choice for dental patients,"^[2] In 1993, the United States Public Health Service reported that "amalgam fillings release small amounts of mercury vapor," but in such a small amount that it "has not been shown to cause any … adverse health effects". This position is not shared by all governments and there is an ongoing dental amalgam controversy. A recent review by an FDA-appointed advisory panel rejected, by a margin of 13-7, the current FDA report on amalgam safety, stating the report's conclusions were unreasonable given the quantity and quality of information currently available. Panelists said remaining uncertainties about the risk of so-called silver fillings demanded further research; in particular, on the effects of mercury-laden fillings on children and the fetuses of pregnant women with fillings, and the release of mercury vapor on insertion and removal of mercury fillings.

Medicine

Mercury and its compounds have been used in medicine for centuries, although they are much less common today than they once were, now that the toxic effects of mercury and its compounds are more widely understood.

Mercury(I) chloride (also known as calomel or mercurous chloride) has traditionally been used as a diuretic, topical disinfectant, and laxative. Mercury(II) chloride (also known as mercuric chloride or corrosive sublimate) was once used to treat syphilis (along with other mercury compounds), although it is so toxic that sometimes the symptoms of its toxicity were confused with those of the syphilis it was believed to treat.^[3] It was also used as a disinfectant. Blue mass, a pill or syrup in which mercury is the main ingredient, was prescribed throughout the 1800s for numerous conditions including constipation, depression, child-bearing and toothaches.^[4] In the early 20th century, mercury was administered to children yearly as a laxative and dewormer, and it was used in teething powders for infants. The mercury containing organohalide Mercurochrome is still widely used but has been banned in some countries such as the U.S.

Since the 1930s some vaccines have contained the preservative thiomersal, which is metabolized or degraded to ethyl mercury. Although it was widely speculated that this mercury-based preservative can cause or trigger autism in children, scientific studies showed no evidence supporting any such link.^[5] Nevertheless thiomersal has been removed from or reduced to trace amounts in all U.S. vaccines recommended for children 6 years of age and under, with the exception of inactivated influenza vaccine.^[6]

Mercury in the form of one of its common ores, cinnabar, remains an important component of Chinese, Tibetan, and Ayurvedic medicine. As problems may arise when these medicines are exported to countries that prohibit the use of mercury in medicines, in recent times, less toxic substitutes have been devised.

Today, the use of mercury in medicine has greatly declined in all respects, especially in developed countries. Thermometers and sphygmomanometers containing mercury were invented in the early 18th and late 19th centuries, respectively. In the early 21st century, their use is declining and has been banned in some countries, states and medical institutions. In 2002, the U.S. Senate passed legislation to phase out the sale of non-prescription mercury thermometers. In 2003, Washington and Maine became the first states to ban mercury blood pressure devices.^[7] Mercury compounds are found in some over-the-counter drugs, including topical antiseptics, stimulant laxatives, diaper-rash ointment, eye drops, and nasal sprays. The FDA has “inadequate data to establish general recognition of the safety and effectiveness,” of the mercury ingredients in these products.^[8] Mercury is still used in some diuretics, although substitutes now exist for most therapeutic uses.

Isotopes

There are seven stable isotopes of mercury with Hg-202 being the most abundant (29.86%). The longest-lived radioisotopes are ¹⁹⁴Hg with a half-life of 444 years, and ²⁰³Hg with a half-life of 46.612 days. Most of the remaining radioisotopes have half-lives that are less than a day. ¹⁹⁹Hg and ²⁰¹Hg are the most often studied NMR-active nuclei, having spins of 1/2 and 3/2 respectively.

Compounds

The most important salts are

• Mercury(I) chloride (AKA calomel) is sometimes still used in medicine and acousto-optical filters;
• Mercury(II) chloride (which is very corrosive, sublimates and is a violent poison);

Safety

See also: mercury poisoning

Mercury and most of its compounds are extremely toxic and are generally handled with care; in cases of spills involving mercury (such as from certain thermometers or fluorescent light bulbs) specific cleaning procedures are used to avoid toxic exposure.^[9] It can be inhaled and absorbed through the skin and mucous membranes, so containers of mercury are securely sealed to avoid spills and evaporation. Heating of mercury, or compounds of mercury that may decompose when heated, is always carried out with adequate ventilation in order to avoid exposure to mercury vapor. The most toxic forms of mercury are its organic compounds, such as dimethylmercury and methylmercury.

Occupational exposure

Due to the health effects of mercury exposure, industrial and commercial uses are regulated in many countries. The World Health Organization, OSHA, and NIOSH all treat mercury as an occupational hazard, and have established specific occupational exposure limits. Environmental releases and disposal of mercury are regulated in the U.S. primarily by the United States Environmental Protection Agency.

Case control studies have shown effects such as tremors, impaired cognitive skills, and sleep disturbance in workers with chronic exposure to mercury vapour even at low concentrations in the range 0.7–42 μg/m³.^[10][11]

A study has shown that acute exposure (4-8 hours) to calculated elemental mercury levels of 1.1 to 44 mg/m³ resulted in chest pain, dyspnea, cough, hemoptysis, impairment of pulmonary function, and evidence of interstitial pneumonitis.^[12]

Acute exposure to mercury vapor has been shown to result in profound central nervous system effects, including psychotic reactions characterized by delirium, hallucinations, and suicidal tendency. Occupational exposure has resulted in broad-ranging functional disturbance, including erethism, irritability, excitability, excessive shyness, and insomnia. With continuing exposure, a fine tremor develops and may escalate to violent muscular spasms. Tremor initially involves the hands and later spreads to the eyelids, lips, and tongue. Long-term, low-level exposure has been associated with more subtle symptoms of erethism, including fatigue, irritability, loss of memory, vivid dreams, and depression.^[13][14]

Treatment

Research on the treatment of mercury poisoning is limited. Currently available drugs for acute mercurial poisoning include chelators N-acetyl-D,L-penicillamine (NAP), British Anti-Lewisite (BAL), 2,3-dimercapto-1-propanesulfonic acid (DMPS), and dimercaptosuccinic acid (DMSA). In one small study including 11 construction workers exposed to elemental mercury, patients were treated with DMSA and NAP.^[15] Chelation therapy with both drugs resulted in the mobilization of a small fraction of the total estimated body mercury. DMSA was able to increase the excretion of mercury to a greater extent than NAP.

Mercury in fish

Fish and shellfish have a natural tendency to concentrate mercury in their bodies, often in the form of methylmercury, a highly toxic organic compound of mercury. Species of fish that are high on the food chain, such as shark, swordfish, king mackerel, albacore tuna, and tilefish contain higher concentrations of mercury than others. This is because mercury is stored in the muscle tissues of fish, and when a predatory fish eats another fish, it assumes the entire body burden of mercury in the consumed fish. Since fish are less efficient at depurating than accumulating methylmercury, fish-tissue concentrations increase over time. Thus species that are high on the food chain amass body burdens of mercury that can be ten times higher, or more, than the species they consume. This process is called biomagnification. The first occurrence of widespread mercury poisoning in humans occurred this way in Minamata, Japan, now called Minamata disease.

The complexities associated with mercury fate and transport are relatively succinctly described by USEPA in their 1997 Mercury Study Report to Congress. Because methylmercury and high levels of elemental mercury can be particularly toxic to unborn or young children, organizations such as the U.S. EPA and FDA recommend that women who are pregnant or plan to become pregnant within the next one or two years, as well as young children avoid eating more than 6 ounces (one average meal) of fish per week.^[16] In the United States the FDA has an action level for methyl mercury in commercial marine and freshwater fish that is 1.0 parts per million (ppm), and in Canada the limit for the total of mercury content is 0.5 ppm.

Species with characteristically low levels of mercury include shrimp, tilapia, salmon, pollock, and catfish (FDA March 2004). The FDA characterizes shrimp, catfish, pollock, salmon, and canned light tuna as low-mercury seafood, although recent tests have indicated that up to 6 percent of canned light tuna may contain high levels.^[17]

References

Additional Resources

External links

• NLM Hazardous Substances Databank – Mercury
• UNIDO/UNDP/GEM Global Mercury Project
• EPA fish consumption guidelines
• ATSDR — ToxFAQs™: Mercury
• WebElements.com – Mercury
• Material Safety Data Sheet – Mercury
• Hg 80 Mercury
• Global Mercury Assessment report 2002 by the UNEP.
• Natural Resources Defense Council (NRDC): Mercury Contamination in Fish guide — NRDC

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