Sporotrichosis natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Alison Leibowitz [2]
Overview
Natural History
- The incubation period of sporotrichosis varies from a few days to multiple months. [1]
Complications
- Cutaneous lesions can become superinfected with bacteria, resulting in cellulitis.
- 5-fluorocytosine therapy may result in photosensitivity[2]
Prognosis
- S. schenckii is an apparent opportunistic pathogen, as severe clinical forms of this disease have been linked with immunodeficient patients.
- Resistance to S. schenckii is not linked to the host’s inherent ability to fight the fungal infection, but rather results from the level of immunity that the host acquires during the initial stage, which is characterized by a large pathogen presence within the organs.[3]
- Resultantly, depending on the host's immune system capacity at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.
References
- ↑ Vásquez-del-Mercado E, Arenas R, Padilla-Desgarenes C. Sporotrichosis. Clinics in Dermatology. 2012;30(4):437-443. doi:10.1016/j.clindermatol.2011.09.017.
- ↑ Shelley WB, Sica PA (1983). "Disseminate sporotrichosis of skin and bone cured with 5-fluorocytosine: Photosensitivity as a complication". J Am Acad Dermatol. 8 (2): 229–35. PMID 6826816.
- ↑ Nascimento RC, Almeida SR (2005). "Humoral immune response against soluble and fractionate antigens in experimental sporotrichosis". FEMS Immunol Med Microbiol. 43 (2): 241–7. doi:10.1016/j.femsim.2004.08.004. PMID 15681154.