Loefflers syndrome overview: Difference between revisions
No edit summary |
No edit summary |
||
| Line 12: | Line 12: | ||
==Differential diagnosis== | ==Differential diagnosis== | ||
Loeffler syndrome must be differentiated from other diseases that cause pulmonary eosinophilia, such as Churg-Strauss, drug and toxin-induced eosinophilic lung diseases, other helminthic and fungal infection related eosinophilic lung diseases, and nonhelminthic infections such as Coccidioidomycosis, and Mycobacterium tuberculosis. | Loeffler syndrome must be differentiated from other diseases that cause pulmonary eosinophilia, such as Churg-Strauss, drug and toxin-induced eosinophilic lung diseases, other helminthic and fungal infection related eosinophilic lung diseases, and nonhelminthic infections such as Coccidioidomycosis, and Mycobacterium tuberculosis. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 14:55, 16 May 2019
|
Löffler's syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Loefflers syndrome overview On the Web |
|
American Roentgen Ray Society Images of Loefflers syndrome overview |
|
Risk calculators and risk factors for Loefflers syndrome overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]
Overview
Loeffler syndrome is rare a form of eosinophilic pulmonary disease, which is characterized by mild respiratory symptoms such as dry cough, wheezing, dyspnea, fever, and blood-tinged sputum containing eosinophil-derived Charcot-Leyden crystals, fleeting migratory pulmonary opacities in chest x-ray, and peripheral blood eosinophilia. Parasitic infections, especially Ascaris lumbricoides, may be the cause, but an identifiable etiologic agent is not found in up to one-third of patients. Transpulmonary passage of helminth larvae is the most precise definition of Loeffler syndrome in the literature, nevertheless, there are plenty of controversial definitions under the cluster of eosinophilic pulmonary disorders. The diagnosis of Löffler syndrome is based on characteristic and often transient respiratory symptoms, chest x-ray findings, and peripheral blood eosinophilia. It requires the exclusion of other types of eosinophilic lung disease. such as acute eosinophilic pneumonia which is a distinct entity with acute onset, severe hypoxemia, and a lack of increased blood eosinophils at the onset of disease. Löffler syndrome is a self-limiting condition which is usually resolved within 3-4 weeks.
Historical perspective
In 1932, Wilhelm Löffler drew attention to the disease in cases of eosinophilic pneumonia caused by the parasites such as Ascaris lumbricoides, Strongyloides stercoralis and the hookworms, such as Ancylostoma duodenale and Necator americanus. Although Löffler only described eosinophilic pneumonia in the context of infection, many authors give the term "Löffler's syndrome" to any form of acute onset pulmonary eosinophilia no matter what the underlying cause. If the cause is unknown, it is specified and called "simple pulmonary eosinophilia".
Pathophysiology
It is understood that Löffler syndrome is the result of transpulmonary passage of helminth larvae. Helminths, with a pulmonary life cycle are responsible for this syndrome, among them are Ascaris lumbricoides, Ascaris suum, Ancylostoma duodenale, Necator americanus, and Strongyloides stercoralis.
Causes
Loeffler syndrome may be caused by Ancylostoma duodenale, Ascaris lumbricoides, Ascaris suum, Necator americanus, Strongyloides stercoralis.
Differential diagnosis
Loeffler syndrome must be differentiated from other diseases that cause pulmonary eosinophilia, such as Churg-Strauss, drug and toxin-induced eosinophilic lung diseases, other helminthic and fungal infection related eosinophilic lung diseases, and nonhelminthic infections such as Coccidioidomycosis, and Mycobacterium tuberculosis.