Rhabdomyosarcoma epidemiology and demographics: Difference between revisions
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*Rhabdomyosarcoma is considered as a most common soft tissue cancers among children and adolescents and it is the third most common extracranial solid tumors during childhood which comes after neuroblastomaand wilms tumor.<ref name="pmid27955730">{{cite journal| author=Dasgupta R, Fuchs J, Rodeberg D| title=Rhabdomyosarcoma. | journal=Semin Pediatr Surg | year= 2016 | volume= 25 | issue= 5 | pages= 276-283 | pmid=27955730 | doi=10.1053/j.sempedsurg.2016.09.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27955730 }} </ref><ref name="pmid10423470">{{cite journal| author=Arndt CA, Crist WM| title=Common musculoskeletal tumors of childhood and adolescence. | journal=N Engl J Med | year= 1999 | volume= 341 | issue= 5 | pages= 342-52 | pmid=10423470 | doi=10.1056/NEJM199907293410507 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10423470 }} </ref> | *Rhabdomyosarcoma is considered as a most common soft tissue cancers among children and adolescents and it is the third most common extracranial solid tumors during childhood which comes after neuroblastomaand wilms tumor.<ref name="pmid27955730">{{cite journal| author=Dasgupta R, Fuchs J, Rodeberg D| title=Rhabdomyosarcoma. | journal=Semin Pediatr Surg | year= 2016 | volume= 25 | issue= 5 | pages= 276-283 | pmid=27955730 | doi=10.1053/j.sempedsurg.2016.09.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27955730 }} </ref><ref name="pmid10423470">{{cite journal| author=Arndt CA, Crist WM| title=Common musculoskeletal tumors of childhood and adolescence. | journal=N Engl J Med | year= 1999 | volume= 341 | issue= 5 | pages= 342-52 | pmid=10423470 | doi=10.1056/NEJM199907293410507 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10423470 }} </ref> | ||
*Rhabdomyosarcoma is responsible for 50% of soft tissue tumors during childhood and 5% of all pediatrics cancers.<ref name="pmid22248972">{{cite journal| author=Dasgupta R, Rodeberg DA| title=Update on rhabdomyosarcoma. | journal=Semin Pediatr Surg | year= 2012 | volume= 21 | issue= 1 | pages= 68-78 | pmid=22248972 | doi=10.1053/j.sempedsurg.2011.10.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22248972 }} </ref> | *Rhabdomyosarcoma is responsible for 50% of soft tissue tumors during childhood and 5% of all pediatrics cancers.<ref name="pmid22248972">{{cite journal| author=Dasgupta R, Rodeberg DA| title=Update on rhabdomyosarcoma. | journal=Semin Pediatr Surg | year= 2012 | volume= 21 | issue= 1 | pages= 68-78 | pmid=22248972 | doi=10.1053/j.sempedsurg.2011.10.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22248972 }} </ref> | ||
*Almost 350 new cases of rhabdomyosarcoma are diagnosed annually. | *Almost 350 new cases of rhabdomyosarcoma are diagnosed annually.<ref name="pmid27955730" /> | ||
===Incidence=== | ===Incidence=== | ||
The overall [[incidence]] of rhabdomyosarcoma in children is 0.45 cases for 100,000 children and 50% of cases are seen in the first decade of life.<ref name=NCI>{{cite web | title = Childhood Rhabdomyosarcoma Treatment| url =http://www.cancer.gov/types/soft-tissue-sarcoma/hp/rhabdomyosarcoma-treatment-pdq}}</ref> Incidence may depend on the histologic subtype of rhabdomyosarcoma: | The overall [[incidence]] of rhabdomyosarcoma in children is 0.45 cases for 100,000 children and 50% of cases are seen in the first decade of life.<ref name="NCI">{{cite web | title = Childhood Rhabdomyosarcoma Treatment| url =http://www.cancer.gov/types/soft-tissue-sarcoma/hp/rhabdomyosarcoma-treatment-pdq}}</ref> Incidence may depend on the histologic subtype of rhabdomyosarcoma: | ||
*Embryonal rhabdomyosarcoma: Embryonal rhabdomyosarcoma peaks in 0 to 4 year age group at approximately 0.4 cases per 100,000 children, with a lower rate in adolescents, approximately 0.15 cases per 100,000 adolescents. | *Embryonal rhabdomyosarcoma: Embryonal rhabdomyosarcoma peaks in 0 to 4 year age group at approximately 0.4 cases per 100,000 children, with a lower rate in adolescents, approximately 0.15 cases per 100,000 adolescents. | ||
*Alveolar rhabdomyosarcoma: The incidence of alveolar rhabdomyosarcoma does not vary by gender and is constant from ages 0 to 19 years at approximately 0.1 case per 100,000 children and adolescents. | *Alveolar rhabdomyosarcoma: The incidence of alveolar rhabdomyosarcoma does not vary by gender and is constant from ages 0 to 19 years at approximately 0.1 case per 100,000 children and adolescents. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Epidemiology and Demographics
- Rhabdomyosarcoma is considered as a most common soft tissue cancers among children and adolescents and it is the third most common extracranial solid tumors during childhood which comes after neuroblastomaand wilms tumor.[1][2]
- Rhabdomyosarcoma is responsible for 50% of soft tissue tumors during childhood and 5% of all pediatrics cancers.[3]
- Almost 350 new cases of rhabdomyosarcoma are diagnosed annually.[1]
Incidence
The overall incidence of rhabdomyosarcoma in children is 0.45 cases for 100,000 children and 50% of cases are seen in the first decade of life.[4] Incidence may depend on the histologic subtype of rhabdomyosarcoma:
- Embryonal rhabdomyosarcoma: Embryonal rhabdomyosarcoma peaks in 0 to 4 year age group at approximately 0.4 cases per 100,000 children, with a lower rate in adolescents, approximately 0.15 cases per 100,000 adolescents.
- Alveolar rhabdomyosarcoma: The incidence of alveolar rhabdomyosarcoma does not vary by gender and is constant from ages 0 to 19 years at approximately 0.1 case per 100,000 children and adolescents.
- Undifferentiated sarcoma: Infants younger than 1 year have a higher incidence of undifferentiated sarcoma.
Age
In general, rhabdomyosarcoma tends to affect individuals less than 45 years of age.
- Rhabdomyosarcoma is most commonly seen in children aged one to five years old. Overall, 65% of all rhabdomyosarcomas are diagnosed in patients under 10 years old.
- Less commonly, it can also present in teens aged 15 to 19, and can even develop in adulthood, though this is even more rare.
References
- ↑ 1.0 1.1 Dasgupta R, Fuchs J, Rodeberg D (2016). "Rhabdomyosarcoma". Semin Pediatr Surg. 25 (5): 276–283. doi:10.1053/j.sempedsurg.2016.09.011. PMID 27955730.
- ↑ Arndt CA, Crist WM (1999). "Common musculoskeletal tumors of childhood and adolescence". N Engl J Med. 341 (5): 342–52. doi:10.1056/NEJM199907293410507. PMID 10423470.
- ↑ Dasgupta R, Rodeberg DA (2012). "Update on rhabdomyosarcoma". Semin Pediatr Surg. 21 (1): 68–78. doi:10.1053/j.sempedsurg.2011.10.007. PMID 22248972.
- ↑ "Childhood Rhabdomyosarcoma Treatment".