ANAPC4: Difference between revisions

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== Interactions ==
== Interactions ==


ANAPC4 has been shown to [[Protein-protein interaction|interact]] with [[ANAPC1]],<ref name=pmid12956947>{{cite journal |doi=10.1016/S0960-9822(03)00581-5 |last=Vodermaier |first=Hartmut C |last2=Gieffers |first2=Christian |last3=Maurer-Stroh |first3=Sebastian |last4=Eisenhaber |first4=Frank |last5=Peters |first5=Jan-Michael |date=September 2003  |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 |journal=Curr. Biol. |volume=13 |issue=17 |pages=1459–68 |publisher= |location = England| issn = 0960-9822| pmid = 12956947 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11076961>{{cite journal |doi=10.1083/jcb.151.4.749 |last=Sumara |first=I |author2=Vorlaufer E |author3=Gieffers C |author4=Peters B H |author5=Peters J M  |date=November 2000  |title=Characterization of vertebrate cohesin complexes and their regulation in prophase |journal=J. Cell Biol. |volume=151 |issue=4 |pages=749–62 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 11076961 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2169443 }}</ref> [[ANAPC5]],<ref name=pmid12956947/> [[CDC27]]<ref name=pmid12956947/><ref name=pmid10922056>{{cite journal |doi=10.1073/pnas.97.16.8973 |last=Gmachl |first=M |author2=Gieffers C |author3=Podtelejnikov A V |author4=Mann M |author5=Peters J M  |date=August 2000  |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=16 |pages=8973–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10922056 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16806 }}</ref> and [[ANAPC7]].<ref name=pmid12956947/>
ANAPC4 has been shown to [[Protein-protein interaction|interact]] with [[ANAPC1]],<ref name=pmid12956947>{{cite journal |doi=10.1016/S0960-9822(03)00581-5 |last=Vodermaier |first=Hartmut C |last2=Gieffers |first2=Christian |last3=Maurer-Stroh |first3=Sebastian |last4=Eisenhaber |first4=Frank |last5=Peters |first5=Jan-Michael |date=September 2003  |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 |journal=Curr. Biol. |volume=13 |issue=17 |pages=1459–68 |publisher= |location = England| issn = 0960-9822| pmid = 12956947 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11076961>{{cite journal |doi=10.1083/jcb.151.4.749 |last=Sumara |first=I |author2=Vorlaufer E |author3=Gieffers C |author4=Peters B H |author5=Peters J M  |date=November 2000  |title=Characterization of vertebrate cohesin complexes and their regulation in prophase |journal=J. Cell Biol. |volume=151 |issue=4 |pages=749–62 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 11076961 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2169443 }}</ref> [[ANAPC5]],<ref name=pmid12956947/> [[CDC27]]<ref name=pmid12956947/><ref name=pmid10922056>{{cite journal |doi=10.1073/pnas.97.16.8973 |last=Gmachl |first=M |author2=Gieffers C |author3=Podtelejnikov A V |author4=Mann M |author5=Peters J M  |date=August 2000  |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=16 |pages=8973–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10922056 | bibcode =2000PNAS...97.8973G | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16806 }}</ref> and [[ANAPC7]].<ref name=pmid12956947/>


== References ==
== References ==
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| citations =  
| citations =  
* {{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
* {{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
* {{cite journal  | vauthors=Yu H, Peters JM, King RW |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex. |journal=Science |volume=279 |issue= 5354 |pages= 1219–22 |year= 1998 |pmid= 9469815 |doi=10.1126/science.279.5354.1219  |display-authors=etal}}
* {{cite journal  | vauthors=Yu H, Peters JM, King RW |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex. |journal=Science |volume=279 |issue= 5354 |pages= 1219–22 |year= 1998 |pmid= 9469815 |doi=10.1126/science.279.5354.1219  |display-authors=etal|bibcode=1998Sci...279.1219Y }}
* {{cite journal  | vauthors=Grossberger R, Gieffers C, Zachariae W |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500–7 |year= 1999 |pmid= 10318877 |doi=10.1074/jbc.274.20.14500  |display-authors=etal}}
* {{cite journal  | vauthors=Grossberger R, Gieffers C, Zachariae W |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500–7 |year= 1999 |pmid= 10318877 |doi=10.1074/jbc.274.20.14500  |display-authors=etal}}
* {{cite journal  | vauthors=Gieffers C, Peters BH, Kramer ER |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317–22 |year= 1999 |pmid= 10500174 |doi=10.1073/pnas.96.20.11317  | pmc=18031  |display-authors=etal}}
* {{cite journal  | vauthors=Gieffers C, Peters BH, Kramer ER |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317–22 |year= 1999 |pmid= 10500174 |doi=10.1073/pnas.96.20.11317  | pmc=18031  |display-authors=etal|bibcode=1999PNAS...9611317G}}
* {{cite journal  | vauthors=Gmachl M, Gieffers C, Podtelejnikov AV |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973–8 |year= 2000 |pmid= 10922056 |doi=10.1073/pnas.97.16.8973  | pmc=16806  |display-authors=etal}}
* {{cite journal  | vauthors=Gmachl M, Gieffers C, Podtelejnikov AV |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973–8 |year= 2000 |pmid= 10922056 |doi=10.1073/pnas.97.16.8973  | pmc=16806  |display-authors=etal|bibcode=2000PNAS...97.8973G}}
* {{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
* {{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
* {{cite journal  | vauthors=Vodermaier HC, Gieffers C, Maurer-Stroh S |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459–68 |year= 2004 |pmid= 12956947 |doi=10.1016/S0960-9822(03)00581-5  |display-authors=etal}}
* {{cite journal  | vauthors=Vodermaier HC, Gieffers C, Maurer-Stroh S |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459–68 |year= 2004 |pmid= 12956947 |doi=10.1016/S0960-9822(03)00581-5  |display-authors=etal}}
* {{cite journal  | vauthors=Kraft C, Herzog F, Gieffers C |title=Mitotic regulation of the human anaphase-promoting complex by phosphorylation. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6598–609 |year= 2004 |pmid= 14657031 |doi= 10.1093/emboj/cdg627  | pmc=291822 |display-authors=etal}}
* {{cite journal  | vauthors=Kraft C, Herzog F, Gieffers C |title=Mitotic regulation of the human anaphase-promoting complex by phosphorylation. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6598–609 |year= 2004 |pmid= 14657031 |doi= 10.1093/emboj/cdg627  | pmc=291822 |display-authors=etal}}
* {{cite journal  | vauthors=Johnson JM, Castle J, Garrett-Engele P |title=Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. |journal=Science |volume=302 |issue= 5653 |pages= 2141–4 |year= 2004 |pmid= 14684825 |doi= 10.1126/science.1090100 |display-authors=etal}}
* {{cite journal  | vauthors=Johnson JM, Castle J, Garrett-Engele P |title=Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. |journal=Science |volume=302 |issue= 5653 |pages= 2141–4 |year= 2004 |pmid= 14684825 |doi= 10.1126/science.1090100 |display-authors=etal|bibcode=2003Sci...302.2141J }}
* {{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
* {{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
}}
}}

Revision as of 16:34, 22 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.[1][2]

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.[2]

Interactions

ANAPC4 has been shown to interact with ANAPC1,[3][4] ANAPC5,[3] CDC27[3][5] and ANAPC7.[3]

References

  1. ↑ Tekolf WA, Biddison WE, Aster RD, Shaw S (October 1982). "Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium". J Immunol. 129 (4): 1474–8. PMID 6180011.
  2. ↑ 2.0 2.1 "Entrez Gene: ANAPC4 anaphase promoting complex subunit 4".
  3. ↑ 3.0 3.1 3.2 3.3 Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947.
  4. ↑ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. UNITED STATES. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.
  5. ↑ Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. ISSN 0027-8424. PMC 16806. PMID 10922056.

External links

Further reading



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