Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene .[1] [2]
The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM][2]
Interactions ANAPC5 has been shown to interact with ANAPC1 ,[3] [4] ANAPC4 ,[3] CDC27 [3] [5] [6] PABPC1 .[5]
References
↑ Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science . 279 (5354): 1219–22. Bibcode :1998Sci...279.1219Y . doi :10.1126/science.279.5354.1219 . PMID 9469815 . ↑ 2.0 2.1 "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5" .↑ 3.0 3.1 3.2 Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol . England. 13 (17): 1459–68. doi :10.1016/S0960-9822(03)00581-5 . ISSN 0960-9822 . PMID 12956947 . ↑ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase" . J. Cell Biol . UNITED STATES. 151 (4): 749–62. doi :10.1083/jcb.151.4.749 . ISSN 0021-9525 . PMC 2169443 PMID 11076961 . ↑ 5.0 5.1 Koloteva-Levine, Nadejda; Pinchasi, Dalia; Pereman, Idan; Zur, Amit; Brandeis, Michael; Elroy-Stein, Orna (May 2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation" . Mol. Cell. Biol . United States. 24 (9): 3577–87. doi :10.1128/MCB.24.9.3577-3587.2004 . ISSN 0270-7306 . PMC 387753 PMID 15082755 . ↑ Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex" . Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode :2000PNAS...97.8973G . doi :10.1073/pnas.97.16.8973 . ISSN 0027-8424 . PMC 16806 PMID 10922056 .
External links Further reading
Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem . 274 (20): 14500–7. doi :10.1074/jbc.274.20.14500 . PMID 10318877 . Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons" . Proc. Natl. Acad. Sci. U.S.A . 96 (20): 11317–22. Bibcode :1999PNAS...9611317G . doi :10.1073/pnas.96.20.11317 . PMC 18031 PMID 10500174 . Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex" . Proc. Natl. Acad. Sci. U.S.A . 97 (16): 8973–8. Bibcode :2000PNAS...97.8973G . doi :10.1073/pnas.97.16.8973 . PMC 16806 PMID 10922056 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol . 13 (17): 1459–68. doi :10.1016/S0960-9822(03)00581-5 . PMID 12956947 . Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation" . EMBO J . 22 (24): 6598–609. doi :10.1093/emboj/cdg627 . PMC 291822 PMID 14657031 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 . Koloteva-Levine N, Pinchasi D, Pereman I, et al. (2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation" . Mol. Cell. Biol . 24 (9): 3577–87. doi :10.1128/MCB.24.9.3577-3587.2004 . PMC 387753 PMID 15082755 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 . PMC 514446 PMID 15302935 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–5. Bibcode :2005Sci...307.1621B . doi :10.1126/science.1105776 . PMID 15761153 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . Turnell AS, Stewart GS, Grand RJ, et al. (2005). "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression". Nature . 438 (7068): 690–5. Bibcode :2005Natur.438..690T . doi :10.1038/nature04151 . PMID 16319895 .
