Antiphospholipid syndrome laboratory findings: Difference between revisions
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=== Criteria for testing | === Criteria for testing Antiphospholipid antibodies: === | ||
* Presence of lupus anticoagulant (LA) in plasma on two or more occasions at least 12 weeks apart. | * Presence of lupus anticoagulant (LA) in plasma on two or more occasions at least 12 weeks apart. | ||
*Presence of moderate to high levels of anticardiolipin (aCL) (IgG or IgM) in serum or plasma ( | *Presence of moderate to high levels of anticardiolipin (aCL) (IgG or IgM) in serum or plasma on two or more occasions at least 12 weeks apart. | ||
*Presence of moderate to high levels of anti–beta-2 glycoprotein I antibodies (IgG or IgM) in serum or plasma (>99th percentile) on two or more occasions at least 12 weeks apart | |||
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!Common Laboratory findings | !Common Laboratory findings | ||
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* Hemolytic anemia | * Hemolytic anemia | ||
* Prolonged activated partial thromboplastin time (aPTT) | * Prolonged activated partial thromboplastin time (aPTT) | ||
* | * Diluted Russell viper venom | ||
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Revision as of 15:11, 24 April 2018
Antiphospholipid syndrome Microchapters |
Differentiating Antiphospholipid syndrome from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Feham Tariq, MD [2]
Overview
Antiphospholipid syndrome (APS) is tested for in the laboratory by both liquid phase coagulation assays (lupus anticoagulant) and solid phase ELISA assays (anti-cardiolipin antibodies). Antibodies found in the plasma os patients with APS are lupus anticoagulant, anticariolipin (aCL), beta-2 glycoprotein I, anti-phosphatidylserine antibodies, anti-prothrombin antibodies. The criteria for testing lupus anticoagulant in the plasma is postivity on 2 or more occasion at least 12 weeks apart.
Laboratory Findings
The following antibodies are found in the plasma of patients with APS:
Laboratory Findings (Antibodies) |
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Criteria for testing Antiphospholipid antibodies:
- Presence of lupus anticoagulant (LA) in plasma on two or more occasions at least 12 weeks apart.
- Presence of moderate to high levels of anticardiolipin (aCL) (IgG or IgM) in serum or plasma on two or more occasions at least 12 weeks apart.
- Presence of moderate to high levels of anti–beta-2 glycoprotein I antibodies (IgG or IgM) in serum or plasma (>99th percentile) on two or more occasions at least 12 weeks apart
Common Laboratory findings |
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