Non-alcoholic fatty liver disease classification: Difference between revisions
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** Stage: depends on degree of fibrosis | ** Stage: depends on degree of fibrosis | ||
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* | ====NAFLD Activity Score (NAS)<ref name="pmid28507929">{{cite journal |vauthors=Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J |title=Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies |journal=J Clin Transl Hepatol |volume=5 |issue=1 |pages=67–75 |year=2017 |pmid=28507929 |pmc=5411359 |doi=10.14218/JCTH.2016.00061 |url=}}</ref><ref name="urlTransplant Pathology Internet Services">{{cite web |url=http://tpis.upmc.com/changebody.cfm?url=/tpis/schema/NAFLD2006.jsp |title=Transplant Pathology Internet Services |format= |work= |accessdate=}}</ref>==== | ||
Total NAS score represents the sum of scores for [[steatosis]], lobular [[inflammation]], and ballooning. | |||
{| class="wikitable" | |||
!Steatosis | |||
!S-Score | |||
|- | |||
|<5%'''<sup>†</sup>''' | |||
|0 | |||
|- | |||
|5–33% | |||
|1 | |||
|- | |||
|34–66% | |||
|2 | |||
|- | |||
|>66% | |||
|3 | |||
|- | |||
!'''Lobular Inflammation''' | |||
!'''L-Score''' | |||
|- | |||
|None<sup>♥</sup> | |||
|0 | |||
|- | |||
|<2 foci | |||
|1 | |||
|- | |||
|2–4 foci | |||
|2 | |||
|- | |||
|>4 foci | |||
|3 | |||
|- | |||
!'''Hepatocyte Balloning''' | |||
!'''B-Score''' | |||
|- | |||
|None | |||
|0 | |||
|- | |||
|Few ballooned cells'''<sup>¥</sup>''' | |||
|1 | |||
|- | |||
|Many ballooned cells'''<sup>₩</sup>''' | |||
|2 | |||
|- | |||
|Interpretation | |||
'''Ranges from 0-8''' | |||
| | |||
* NAS scores of 0-2 is not diagnostic of NASH | |||
* Scores of 3-4 is borderline for NASH | |||
* Scores of 5-8 is diagnostic of NASH | |||
|- | |||
| colspan="2" | | |||
* '''†''' = Refers to the quantity of surface area involved by means of steatosis as evaluated on low to medium power examination; minimum steatosis (<5%) gets a rating of 0 to keep away from giving excess weight to biopsies with little or no fatty change. | |||
* ♥ = Acidophil bodies are not protected by this evaluation, neither is the portal irritation. | |||
* '''¥''' = The term "few" means rare however specific ballooned hepatocytes as well as cases which are diagnostically borderline. | |||
* '''₩''' = Maximum cases with distinguished ballooning additionally had Mallory's hyaline, howeverMallory's hyaline isn't scored one after the other for the NAS. | |||
|} | |||
==References== | ==References== | ||
Revision as of 17:01, 21 December 2017
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Non-Alcoholic Fatty Liver Disease Microchapters |
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Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases |
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Case studies |
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Non-alcoholic fatty liver disease classification On the Web |
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Non-alcoholic fatty liver disease classification in the news |
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Directions to Hospitals Treating Non-alcoholic fatty liver disease |
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Risk calculators and risk factors for Non-alcoholic fatty liver disease classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Non-alcoholic fatty liver disease may be classified based on clinical presentation into non-alcoholic fatty liver and non-alcoholic steatohepatitis.
Classification
Non-alcoholic fatty liver disease may be classified based on clinical presentation into non-alcoholic fatty liver and non-alcoholic steatohepatitis.[1][2][3]
| Based on clinical presentation | |
|---|---|
| Non-alcoholic fatty aliver | Non-alcoholic steatohepatitis |
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| Based on histopathology | |
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NAFLD Activity Score (NAS)[4][5]
Total NAS score represents the sum of scores for steatosis, lobular inflammation, and ballooning.
| Steatosis | S-Score |
|---|---|
| <5%† | 0 |
| 5–33% | 1 |
| 34–66% | 2 |
| >66% | 3 |
| Lobular Inflammation | L-Score |
| None♥ | 0 |
| <2 foci | 1 |
| 2–4 foci | 2 |
| >4 foci | 3 |
| Hepatocyte Balloning | B-Score |
| None | 0 |
| Few ballooned cells¥ | 1 |
| Many ballooned cells₩ | 2 |
| Interpretation
Ranges from 0-8 |
|
| |
References
- ↑ Hashimoto E, Tokushige K, Ludwig J (2015). "Diagnosis and classification of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: Current concepts and remaining challenges". Hepatol Res. 45 (1): 20–8. doi:10.1111/hepr.12333. PMID 24661406.
- ↑ Cobbina E, Akhlaghi F (2017). "Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters". Drug Metab Rev. 49 (2): 197–211. doi:10.1080/03602532.2017.1293683. PMC 5576152. PMID 28303724.
- ↑ Monteiro JM, Monteiro GM, Caroli-Bottino A, Pannain VL (2014). "Nonalcoholic fatty liver disease: different classifications concordance and relationship between degrees of morphological features and spectrum of the disease". Anal Cell Pathol (Amst). 2014: 526979. doi:10.1155/2014/526979. PMC 4333905. PMID 25763333.
- ↑ Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J (2017). "Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies". J Clin Transl Hepatol. 5 (1): 67–75. doi:10.14218/JCTH.2016.00061. PMC 5411359. PMID 28507929.
- ↑ "Transplant Pathology Internet Services".