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{{Infobox_gene}}
{{PBB_Controls
'''Gamma-soluble NSF attachment protein''' is a [[protein]] that in humans is encoded by the ''NAPG'' [[gene]].<ref name="pmid9269766">{{cite journal | vauthors = Lemons PP, Chen D, Bernstein AM, Bennett MK, Whiteheart SW | title = Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery | journal = Blood | volume = 90 | issue = 4 | pages = 1490–500 |date=Sep 1997 | pmid = 9269766 | pmc = | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8774| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = N-ethylmaleimide-sensitive factor attachment protein, gamma
| HGNCid = 7642
| Symbol = NAPG
| AltSymbols =; GAMMASNAP
| OMIM = 603216
| ECnumber = 
| Homologene = 2838
| MGIid = 104561
| GeneAtlas_image1 = PBB_GE_NAPG_210048_at_tn.png
| Function = {{GNF_GO|id=GO:0005478 |text = transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0006891 |text = intra-Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0006944 |text = membrane fusion}} {{GNF_GO|id=GO:0050821 |text = protein stabilization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8774
    | Hs_Ensembl = ENSG00000134265
    | Hs_RefseqProtein = NP_003817
    | Hs_RefseqmRNA = NM_003826
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 10516031
    | Hs_GenLoc_end = 10540371
    | Hs_Uniprot = Q99747
    | Mm_EntrezGene = 108123
    | Mm_Ensembl = ENSMUSG00000024581
    | Mm_RefseqmRNA = XM_001000731
    | Mm_RefseqProtein = XP_001000731
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 63103285
    | Mm_GenLoc_end = 63124817
    | Mm_Uniprot = Q8C1T5
  }}
}}
'''N-ethylmaleimide-sensitive factor attachment protein, gamma''', also known as '''NAPG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8774| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[N-ethylmaleimide sensitive fusion protein|NSF]] and SNAPs (NSF attachment proteins) are general elements of the cellular [[membrane transport]] apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates [[platelet]] [[exocytosis]] and controls the [[membrane fusion]] events of this process.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = NSF and SNAPs are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.<ref name="entrez">{{cite web | title = Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8774| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Wilson DW, Whiteheart SW, Wiedmann M, etal |title=A multisubunit particle implicated in membrane fusion. |journal=J. Cell Biol. |volume=117 |issue= 3 |pages= 531–8 |year= 1992 |pmid= 1315316 |doi=10.1083/jcb.117.3.531  | pmc=2289450 }}
| citations =
*{{cite journal   |vauthors=Whiteheart SW, Brunner M, Wilson DW, etal |title=Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes. |journal=J. Biol. Chem. |volume=267 |issue= 17 |pages= 12239–43 |year= 1992 |pmid= 1601890 |doi=  }}
*{{cite journal | author=Wilson DW, Whiteheart SW, Wiedmann M, ''et al.'' |title=A multisubunit particle implicated in membrane fusion. |journal=J. Cell Biol. |volume=117 |issue= 3 |pages= 531-8 |year= 1992 |pmid= 1315316 |doi=  }}
*{{cite journal   |vauthors=Whiteheart SW, Griff IC, Brunner M, etal |title=SNAP family of NSF attachment proteins includes a brain-specific isoform. |journal=Nature |volume=362 |issue= 6418 |pages= 353–5 |year= 1993 |pmid= 8455721 |doi= 10.1038/362353a0 }}
*{{cite journal | author=Whiteheart SW, Brunner M, Wilson DW, ''et al.'' |title=Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes. |journal=J. Biol. Chem. |volume=267 |issue= 17 |pages= 12239-43 |year= 1992 |pmid= 1601890 |doi=  }}
*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Whiteheart SW, Griff IC, Brunner M, ''et al.'' |title=SNAP family of NSF attachment proteins includes a brain-specific isoform. |journal=Nature |volume=362 |issue= 6418 |pages= 353-5 |year= 1993 |pmid= 8455721 |doi= 10.1038/362353a0 }}
*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | vauthors=Mastick CC, Falick AL |title=Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes. |journal=Endocrinology |volume=138 |issue= 6 |pages= 2391–7 |year= 1997 |pmid= 9165027 |doi=10.1210/en.138.6.2391 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal   |vauthors=Subramaniam VN, Loh E, Horstmann H, etal |title=Preferential association of syntaxin 8 with the early endosome. |journal=J. Cell Sci. |volume=113 |issue=  6|pages= 997–1008 |year= 2000 |pmid= 10683148 |doi=  }}
*{{cite journal  | author=Mastick CC, Falick AL |title=Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes. |journal=Endocrinology |volume=138 |issue= 6 |pages= 2391-7 |year= 1997 |pmid= 9165027 |doi= }}
*{{cite journal   |vauthors=Chen D, Xu W, He P, etal |title=Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13127–35 |year= 2001 |pmid= 11278501 |doi= 10.1074/jbc.M009424200 }}
*{{cite journal  | author=Lemons PP, Chen D, Bernstein AM, ''et al.'' |title=Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. |journal=Blood |volume=90 |issue= 4 |pages= 1490-500 |year= 1997 |pmid= 9269766 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Subramaniam VN, Loh E, Horstmann H, ''et al.'' |title=Preferential association of syntaxin 8 with the early endosome. |journal=J. Cell. Sci. |volume=113 ( Pt 6) |issue=  |pages= 997-1008 |year= 2000 |pmid= 10683148 |doi=  }}
*{{cite journal   |vauthors=Tani K, Shibata M, Kawase K, etal |title=Mapping of functional domains of gamma-SNAP. |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 13531–8 |year= 2003 |pmid= 12554740 |doi= 10.1074/jbc.M213205200 }}
*{{cite journal | author=Chen D, Xu W, He P, ''et al.'' |title=Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13127-35 |year= 2001 |pmid= 11278501 |doi= 10.1074/jbc.M009424200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Tani K, Shibata M, Kawase K, ''et al.'' |title=Mapping of functional domains of gamma-SNAP. |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 13531-8 |year= 2003 |pmid= 12554740 |doi= 10.1074/jbc.M213205200 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Human proteins]]
{{WikiDoc Sources}}
 
 
{{gene-18-stub}}

Latest revision as of 20:25, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Gamma-soluble NSF attachment protein is a protein that in humans is encoded by the NAPG gene.[1][2]

Function

NSF and SNAPs (NSF attachment proteins) are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.[2]

References

  1. ↑ Lemons PP, Chen D, Bernstein AM, Bennett MK, Whiteheart SW (Sep 1997). "Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery". Blood. 90 (4): 1490–500. PMID 9269766.
  2. ↑ 2.0 2.1 "Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma".

Further reading


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