GCHFR: Difference between revisions

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{{Infobox_gene}}
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'''GTP cyclohydrolase 1 feedback regulatory protein''' is an [[enzyme]] that in humans is encoded by the ''GCHFR'' [[gene]].<ref name="pmid8702680">{{cite journal |vauthors=Milstien S, Jaffe H, Kowlessur D, Bonner TI | title = Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP | journal = J. Biol. Chem. | volume = 271 | issue = 33 | pages = 19743–51 |date=Oct 1996 | pmid = 8702680 | pmc =  | doi =10.1074/jbc.271.33.19743 }}</ref><ref name="pmid1286669">{{cite journal |vauthors=Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R | title = Human liver protein map: a reference database established by microsequencing and gel comparison | journal = Electrophoresis | volume = 13 | issue = 12 | pages = 992–1001 |date=Mar 1993 | pmid = 1286669 | pmc =  | doi =10.1002/elps.11501301201 |display-authors=etal}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GCHFR GTP cyclohydrolase I feedback regulator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2644| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_GCHFR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1is7.
| PDB = {{PDB2|1is7}}, {{PDB2|1is8}}, {{PDB2|1jg5}}, {{PDB2|1wpl}}
| Name = GTP cyclohydrolase I feedback regulator
| HGNCid = 4194
| Symbol = GCHFR
| AltSymbols =; P35; GFRP; HsT16933; MGC138467; MGC138469
| OMIM = 602437
| ECnumber =
| Homologene = 3849
| MGIid = 2443977
  | GeneAtlas_image1 = PBB_GE_GCHFR_204867_at_tn.png
  | Function =
| Component =
| Process = {{GNF_GO|id=GO:0006809 |text = nitric oxide biosynthetic process}} {{GNF_GO|id=GO:0042133 |text = neurotransmitter metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2644
    | Hs_Ensembl = ENSG00000137880
    | Hs_RefseqProtein = NP_005249
    | Hs_RefseqmRNA = NM_005258
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 38843558
    | Hs_GenLoc_end = 38847198
    | Hs_Uniprot = P30047
    | Mm_EntrezGene = 320415
    | Mm_Ensembl = ENSMUSG00000046814
    | Mm_RefseqmRNA = NM_177157
    | Mm_RefseqProtein = NP_796131
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 118859229
    | Mm_GenLoc_end = 118863830
    | Mm_Uniprot = Q4VAF4
  }}
}}
'''GTP cyclohydrolase I feedback regulator''', also known as '''GCHFR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GCHFR GTP cyclohydrolase I feedback regulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2644| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.<ref name="entrez">{{cite web | title = Entrez Gene: GCHFR GTP cyclohydrolase I feedback regulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2644| accessdate = }}</ref>
| summary_text = GTP cyclohydrolase I feedback regulatory [[protein]] binds to and mediates [[tetrahydrobiopterin]] inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating [[phenylalanine]] metabolism in the liver and in the production of biogenic amine neurotransmitters and [[nitric oxide]].<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hochstrasser DF, Frutiger S, Paquet N, ''et al.'' |title=Human liver protein map: a reference database established by microsequencing and gel comparison. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 992-1001 |year= 1993 |pmid= 1286669 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  |vauthors=Yoneyama T, Brewer JM, Hatakeyama K |title=GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 9690–6 |year= 1997 |pmid= 9092499 |doi=10.1074/jbc.272.15.9690 }}
*{{cite journal  | author=Milstien S, Jaffe H, Kowlessur D, Bonner TI |title=Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 19743-51 |year= 1996 |pmid= 8702680 |doi= }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Yoneyama T, Brewer JM, Hatakeyama K |title=GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression. |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 9690-6 |year= 1997 |pmid= 9092499 |doi=  }}
*{{cite journal  |vauthors=Bader G, Schiffmann S, Herrmann A |title=Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP |journal=J. Mol. Biol. |volume=312 |issue= 5 |pages= 1051–7 |year= 2001 |pmid= 11580249 |doi= 10.1006/jmbi.2001.5011 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Werner ER, Bahrami S, Heller R, Werner-Felmayer G |title=Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10129–33 |year= 2002 |pmid= 11799107 |doi= 10.1074/jbc.M107326200 }}
*{{cite journal  | author=Bader G, Schiffmann S, Herrmann A, ''et al.'' |title=Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP. |journal=J. Mol. Biol. |volume=312 |issue= 5 |pages= 1051-7 |year= 2001 |pmid= 11580249 |doi= 10.1006/jmbi.2001.5011 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Werner ER, Bahrami S, Heller R, Werner-Felmayer G |title=Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10129-33 |year= 2002 |pmid= 11799107 |doi= 10.1074/jbc.M107326200 }}
*{{cite journal  |vauthors=Gesierich A, Niroomand F, Tiefenbacher CP |title=Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism |journal=Basic Res. Cardiol. |volume=98 |issue= 2 |pages= 69–75 |year= 2003 |pmid= 12607127 |doi= 10.1007/s00395-003-0394-y }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gesierich A, Niroomand F, Tiefenbacher CP |title=Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism. |journal=Basic Res. Cardiol. |volume=98 |issue= 2 |pages= 69-75 |year= 2003 |pmid= 12607127 |doi= 10.1007/s00395-003-0394-y }}
*{{cite journal  |vauthors=Kalivendi S, Hatakeyama K, Whitsett J |title=Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP? |journal=Free Radic. Biol. Med. |volume=38 |issue= 4 |pages= 481–91 |year= 2006 |pmid= 15649650 |doi= 10.1016/j.freeradbiomed.2004.11.004 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Chavan B, Gillbro JM, Rokos H, Schallreuter KU |title=GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes |journal=J. Invest. Dermatol. |volume=126 |issue= 11 |pages= 2481–9 |year= 2007 |pmid= 16778797 |doi= 10.1038/sj.jid.5700425 }}
*{{cite journal  | author=Kalivendi S, Hatakeyama K, Whitsett J, ''et al.'' |title=Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP? |journal=Free Radic. Biol. Med. |volume=38 |issue= 4 |pages= 481-91 |year= 2006 |pmid= 15649650 |doi= 10.1016/j.freeradbiomed.2004.11.004 }}
*{{cite journal  |vauthors=Ohta E, Funayama M, Ichinose H |title=Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia |journal=Arch. Neurol. |volume=63 |issue= 11 |pages= 1605–10 |year= 2006 |pmid= 17101830 |doi= 10.1001/archneur.63.11.1605 |display-authors=etal}}
*{{cite journal  | author=Chavan B, Gillbro JM, Rokos H, Schallreuter KU |title=GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes. |journal=J. Invest. Dermatol. |volume=126 |issue= 11 |pages= 2481-9 |year= 2007 |pmid= 16778797 |doi= 10.1038/sj.jid.5700425 }}
*{{cite journal  |vauthors=Kontostavlaki DP, Panayotacopoulou MT, Sluijs JA |title=Co-expression of tyrosine hydroxylase and GTP cyclohydrolase I in arginine vasopressin-synthesizing neurons of the human supraoptic nucleus demonstrated by laser microdissection and real-time PCR |journal=Neuroendocrinology |volume=84 |issue= 6 |pages= 386–95 |year= 2007 |pmid= 17135716 |doi= 10.1159/000097487 |display-authors=etal}}
*{{cite journal  | author=Ohta E, Funayama M, Ichinose H, ''et al.'' |title=Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia. |journal=Arch. Neurol. |volume=63 |issue= 11 |pages= 1605-10 |year= 2006 |pmid= 17101830 |doi= 10.1001/archneur.63.11.1605 }}
*{{cite journal  | author=Kontostavlaki DP, Panayotacopoulou MT, Sluijs JA, ''et al.'' |title=Co-expression of tyrosine hydroxylase and GTP cyclohydrolase I in arginine vasopressin-synthesizing neurons of the human supraoptic nucleus demonstrated by laser microdissection and real-time PCR. |journal=Neuroendocrinology |volume=84 |issue= 6 |pages= 386-95 |year= 2007 |pmid= 17135716 |doi= 10.1159/000097487 }}
}}
}}
*{{cite journal  |vauthors=Nandi M, Kelly P, Vallance P, Leiper J |title=Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production |journal=Vasc. Med. |volume=13 |issue= 1 |pages= 29–36 |year= 2008 |pmid= 18372436 |doi= 10.1177/1358863X07085916 }}
*{{cite journal  |vauthors=Ionova IA, Vasques-Vivar J, Whitsett J |title=Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes |journal=Am. J. Physiol. |volume=295 |issue= 5 |pages= H2178–87 |year= 2008 |pmid= 18835915 |doi= 10.1152/ajpheart.00748.2008  | pmc=2614582 |display-authors=etal}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2644}}
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Latest revision as of 08:42, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

GTP cyclohydrolase 1 feedback regulatory protein is an enzyme that in humans is encoded by the GCHFR gene.[1][2][3]

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.[3]

References

  1. ↑ Milstien S, Jaffe H, Kowlessur D, Bonner TI (Oct 1996). "Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP". J. Biol. Chem. 271 (33): 19743–51. doi:10.1074/jbc.271.33.19743. PMID 8702680.
  2. ↑ Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R, et al. (Mar 1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669.
  3. ↑ 3.0 3.1 "Entrez Gene: GCHFR GTP cyclohydrolase I feedback regulator".

Further reading



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