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{{Infobox_gene}}
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'''Toll interacting protein''', also known as '''TOLLIP''', is an inhibitory [[Signal transducing adaptor protein|adaptor protein]] that in humans is encoded by the ''TOLLIP'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TOLLIP toll interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54472| accessdate = }}</ref><ref name="pmid9426216">{{cite journal |vauthors=Volpe F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K | title = The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex | journal = FEBS Lett. | volume = 419 | issue = 1 | pages = 41–4 |date=December 1997 | pmid = 9426216 | doi = 10.1016/S0014-5793(97)01426-9| url = }}</ref><ref name="pmid10854325">{{cite journal |vauthors=Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F | title = Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor | journal = Nat. Cell Biol. | volume = 2 | issue = 6 | pages = 346–51 |date=June 2000 | pmid = 10854325 | doi = 10.1038/35014038 | url =  }}</ref>
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==Function==
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It is an inhibitory adaptor protein within [[Toll-like receptor]]s (TLR).<ref name="pmid11441107">{{cite journal |vauthors=Bulut Y, Faure E, Thomas L, Equils O, Arditi M | title = Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling | journal = J. Immunol. | volume = 167 | issue = 2 | pages = 987–94 |date=July 2001 | pmid = 11441107 | doi = 10.4049/jimmunol.167.2.987| url = http://www.jimmunol.org/cgi/content/abstract/167/2/987 }}</ref> The TLR pathway is a part of the [[innate immune system]] that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response.
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}}
==Clinical significance==


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Polymorphism (biology)|Polymorphisms]] in TLR genes have been implicated in various diseases like [[atopic dermatitis]].<ref name="pmid17362526">{{cite journal |vauthors=Schimming TT, Parwez Q, Petrasch-Parwez E, Nothnagel M, Epplen JT, Hoffjan S | title = Association of toll-interacting protein gene polymorphisms with atopic dermatitis | journal = BMC Dermatol. | volume = 7| pages = 3 | year = 2007 | pmid = 17362526 | pmc = 1832210 | doi = 10.1186/1471-5945-7-3 | url =  }}</ref> Recently, variations in the TOLLIP gene have been associated with tuberculosis and idiopathic pulmonary fibrosis.<ref>{{cite journal | year = 2012 | title =  Human TOLLIP Regulates TLR2 and TLR4 Signaling and Its Polymorphisms Are Associated with Susceptibility to Tuberculosis| journal = J Immunol | volume = 189 | issue = 4| pages = 1737–46 | doi = 10.4049/jimmunol.1103541 | pmid=22778396 | pmc=3428135 | vauthors=Shah JA, Vary JC, Chau TT, Bang ND, Yen NT, Farrar JJ, Dunstan SJ, Hawn TR}}</ref><ref>{{cite journal | year = | title = Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study| url = | journal = The Lancet Respiratory Medicine | volume = 1 | issue = 4| pages = 309–317 | doi = 10.1016/S2213-2600(13)70045-6 }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_TOLLIP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wgl.
| PDB = {{PDB2|1wgl}}
| Name = Toll interacting protein
| HGNCid = 16476
| Symbol = TOLLIP
| AltSymbols =; FLJ33531; IL-1RAcPIP
| OMIM = 606277
| ECnumber =
| Homologene = 10375
| MGIid = 1891808
| GeneAtlas_image1 = PBB_GE_TOLLIP_217930_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005121 |text = Toll binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
  | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0045092 |text = interleukin-18 receptor complex}} {{GNF_GO|id=GO:0045323 |text = interleukin-1 receptor complex}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0016310 |text = phosphorylation}} {{GNF_GO|id=GO:0045321 |text = leukocyte activation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54472
    | Hs_Ensembl = ENSG00000078902
    | Hs_RefseqProtein = NP_061882
    | Hs_RefseqmRNA = NM_019009
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 1252178
    | Hs_GenLoc_end = 1287425
    | Hs_Uniprot = Q9H0E2
    | Mm_EntrezGene = 54473
    | Mm_Ensembl = ENSMUSG00000025139
    | Mm_RefseqmRNA = NM_023764
    | Mm_RefseqProtein = NP_076253
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 141684203
    | Mm_GenLoc_end = 141711805
    | Mm_Uniprot = Q8BQL7
  }}
}}
'''Toll interacting protein''', also known as '''TOLLIP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TOLLIP toll interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54472| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
TOLLIP has been shown to [[Protein-protein interaction|interact]] with [[TOM1]],<ref name=pmid14563850>{{cite journal |last=Yamakami |first=Megumi |authorlink= |author2=Yoshimori Tamotsu |author3=Yokosawa Hideyoshi  |date=Dec 2003 |title=Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin |journal=J. Biol. Chem. |volume=278 |issue=52 |pages=52865–72 |publisher= |location = United States| issn = 0021-9258| pmid = 14563850 |doi = 10.1074/jbc.M306740200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TLR 2]],<ref name=pmid11751856>{{cite journal |last=Zhang |first=Guolong |authorlink= |author2=Ghosh Sankar  |date=Mar 2002 |title=Negative regulation of toll-like receptor-mediated signaling by Tollip |journal=J. Biol. Chem. |volume=277 |issue=9 |pages=7059–65 |publisher= |location = United States| issn = 0021-9258| pmid = 11751856 |doi = 10.1074/jbc.M109537200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TLR 4]]<ref name=pmid11751856/> and [[IL1RAP]].<ref name=pmid10854325 />
| section_title =  
| summary_text =  
}}


==References==
==References==
{{reflist|2}}
{{Reflist|2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nilsen KH |title=Malignant lymphoma and rheumatic symptoms. |journal=N. Z. Med. J. |volume=83 |issue= 563 |pages= 320-2 |year= 1976 |pmid= 1085432 |doi=  }}
*{{cite journal  | author=Nilsen KH |title=Malignant lymphoma and rheumatic symptoms |journal=N. Z. Med. J. |volume=83 |issue= 563 |pages= 320–2 |year= 1976 |pmid= 1085432 |doi=  }}
*{{cite journal  | author=Volpe F, Clatworthy J, Kaptein A, ''et al.'' |title=The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex. |journal=FEBS Lett. |volume=419 |issue= 1 |pages= 41-4 |year= 1998 |pmid= 9426216 |doi=  }}
*{{cite journal  |vauthors=Volpe F, Clatworthy J, Kaptein A |title=The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex |journal=FEBS Lett. |volume=419 |issue= 1 |pages= 41–4 |year= 1998 |pmid= 9426216 |doi=10.1016/S0014-5793(97)01426-9 }}
*{{cite journal  | author=Burns K, Clatworthy J, Martin L, ''et al.'' |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. |journal=Nat. Cell Biol. |volume=2 |issue= 6 |pages= 346-51 |year= 2000 |pmid= 10854325 |doi= 10.1038/35014038 }}
*{{cite journal  |vauthors=Burns K, Clatworthy J, Martin L |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor |journal=Nat. Cell Biol. |volume=2 |issue= 6 |pages= 346–51 |year= 2000 |pmid= 10854325 |doi= 10.1038/35014038 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  |vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072}}
*{{cite journal  | author=Bulut Y, Faure E, Thomas L, ''et al.'' |title=Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. |journal=J. Immunol. |volume=167 |issue= 2 |pages= 987-94 |year= 2001 |pmid= 11441107 |doi=  }}
*{{cite journal  |vauthors=Bulut Y, Faure E, Thomas L |title=Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling |journal=J. Immunol. |volume=167 |issue= 2 |pages= 987–94 |year= 2001 |pmid= 11441107 |doi=  10.4049/jimmunol.167.2.987}}
*{{cite journal  | author=Zhang G, Ghosh S |title=Negative regulation of toll-like receptor-mediated signaling by Tollip. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7059-65 |year= 2002 |pmid= 11751856 |doi= 10.1074/jbc.M109537200 }}
*{{cite journal  |vauthors=Zhang G, Ghosh S |title=Negative regulation of toll-like receptor-mediated signaling by Tollip |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7059–65 |year= 2002 |pmid= 11751856 |doi= 10.1074/jbc.M109537200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Yamakami M, Yoshimori T, Yokosawa H |title=Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52865-72 |year= 2004 |pmid= 14563850 |doi= 10.1074/jbc.M306740200 }}
*{{cite journal  |vauthors=Yamakami M, Yoshimori T, Yokosawa H |title=Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52865–72 |year= 2004 |pmid= 14563850 |doi= 10.1074/jbc.M306740200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Katoh Y, Shiba Y, Mitsuhashi H, ''et al.'' |title=Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24435-43 |year= 2004 |pmid= 15047686 |doi= 10.1074/jbc.M400059200 }}
*{{cite journal  |vauthors=Katoh Y, Shiba Y, Mitsuhashi H |title=Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24435–43 |year= 2004 |pmid= 15047686 |doi= 10.1074/jbc.M400059200 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  |vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  |vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal  | author=Ohnuma K, Yamochi T, Uchiyama M, ''et al.'' |title=CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells. |journal=Mol. Cell. Biol. |volume=25 |issue= 17 |pages= 7743-57 |year= 2005 |pmid= 16107720 |doi= 10.1128/MCB.25.17.7743-7757.2005 }}
*{{cite journal  |vauthors=Ohnuma K, Yamochi T, Uchiyama M |title=CD26 Mediates Dissociation of Tollip and IRAK-1 from Caveolin-1 and Induces Upregulation of CD86 on Antigen-Presenting Cells |journal=Mol. Cell. Biol. |volume=25 |issue= 17 |pages= 7743–57 |year= 2005 |pmid= 16107720 |doi= 10.1128/MCB.25.17.7743-7757.2005 | pmc=1190283 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  |vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501 }}
*{{cite journal  | author=Katoh Y, Imakagura H, Futatsumori M, Nakayama K |title=Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 1 |pages= 143-9 |year= 2006 |pmid= 16412388 |doi= 10.1016/j.bbrc.2005.12.156 }}
*{{cite journal  |vauthors=Katoh Y, Imakagura H, Futatsumori M, Nakayama K |title=Recruitment of clathrin onto endosomes by the Tom1-Tollip complex |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 1 |pages= 143–9 |year= 2006 |pmid= 16412388 |doi= 10.1016/j.bbrc.2005.12.156 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | author=Brissoni B, Agostini L, Kropf M, ''et al.'' |title=Intracellular trafficking of interleukin-1 receptor I requires Tollip. |journal=Curr. Biol. |volume=16 |issue= 22 |pages= 2265-70 |year= 2007 |pmid= 17113392 |doi= 10.1016/j.cub.2006.09.062 }}
*{{cite journal  |vauthors=Brissoni B, Agostini L, Kropf M |title=Intracellular trafficking of interleukin-1 receptor I requires Tollip |journal=Curr. Biol. |volume=16 |issue= 22 |pages= 2265–70 |year= 2007 |pmid= 17113392 |doi= 10.1016/j.cub.2006.09.062 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=54472}}
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{{TLR signaling pathway}}


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Revision as of 12:07, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene.[1][2][3]

Function

It is an inhibitory adaptor protein within Toll-like receptors (TLR).[4] The TLR pathway is a part of the innate immune system that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response.

Clinical significance

Polymorphisms in TLR genes have been implicated in various diseases like atopic dermatitis.[5] Recently, variations in the TOLLIP gene have been associated with tuberculosis and idiopathic pulmonary fibrosis.[6][7]

Interactions

TOLLIP has been shown to interact with TOM1,[8] TLR 2,[9] TLR 4[9] and IL1RAP.[3]

References

  1. ↑ "Entrez Gene: TOLLIP toll interacting protein".
  2. ↑ Volpe F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K (December 1997). "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex". FEBS Lett. 419 (1): 41–4. doi:10.1016/S0014-5793(97)01426-9. PMID 9426216.
  3. ↑ 3.0 3.1 Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.
  4. ↑ Bulut Y, Faure E, Thomas L, Equils O, Arditi M (July 2001). "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling". J. Immunol. 167 (2): 987–94. doi:10.4049/jimmunol.167.2.987. PMID 11441107.
  5. ↑ Schimming TT, Parwez Q, Petrasch-Parwez E, Nothnagel M, Epplen JT, Hoffjan S (2007). "Association of toll-interacting protein gene polymorphisms with atopic dermatitis". BMC Dermatol. 7: 3. doi:10.1186/1471-5945-7-3. PMC 1832210. PMID 17362526.
  6. ↑ Shah JA, Vary JC, Chau TT, Bang ND, Yen NT, Farrar JJ, Dunstan SJ, Hawn TR (2012). "Human TOLLIP Regulates TLR2 and TLR4 Signaling and Its Polymorphisms Are Associated with Susceptibility to Tuberculosis". J Immunol. 189 (4): 1737–46. doi:10.4049/jimmunol.1103541. PMC 3428135. PMID 22778396.
  7. ↑ "Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study". The Lancet Respiratory Medicine. 1 (4): 309–317. doi:10.1016/S2213-2600(13)70045-6.
  8. ↑ Yamakami, Megumi; Yoshimori Tamotsu; Yokosawa Hideyoshi (Dec 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". J. Biol. Chem. United States. 278 (52): 52865–72. doi:10.1074/jbc.M306740200. ISSN 0021-9258. PMID 14563850.
  9. ↑ 9.0 9.1 Zhang, Guolong; Ghosh Sankar (Mar 2002). "Negative regulation of toll-like receptor-mediated signaling by Tollip". J. Biol. Chem. United States. 277 (9): 7059–65. doi:10.1074/jbc.M109537200. ISSN 0021-9258. PMID 11751856.

Further reading



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