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[[Hypertriglyceridemia]] can occur due to various causes, including genetics, familial, metabolic and drugs
[[Hypertriglyceridemia]] can occur due to various causes, including genetics, familial, metabolic and drugs
==Causes==
==Causes==
===Life Threatening Causes===
===Common Causes===
*[[Diabetes mellitus]]
*[[Obesity]]
===Primary hypertriglyceridemia===
===Primary hypertriglyceridemia===
====Genetics <ref name="pmid19355858">{{cite journal| author=Kolovou GD, Anagnostopoulou KK, Kostakou PM, Bilianou H, Mikhailidis DP| title=Primary and secondary hypertriglyceridaemia. | journal=Curr Drug Targets | year= 2009 | volume= 10 | issue= 4 | pages= 336-43 | pmid=19355858 | doi= | pmc= | url= }} </ref>====
====Genetics <ref name="pmid19355858">{{cite journal| author=Kolovou GD, Anagnostopoulou KK, Kostakou PM, Bilianou H, Mikhailidis DP| title=Primary and secondary hypertriglyceridaemia. | journal=Curr Drug Targets | year= 2009 | volume= 10 | issue= 4 | pages= 336-43 | pmid=19355858 | doi= | pmc= | url= }} </ref>====

Revision as of 19:12, 17 September 2013

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Overview

Hypertriglyceridemia can occur due to various causes, including genetics, familial, metabolic and drugs

Causes

Life Threatening Causes

Common Causes

Primary hypertriglyceridemia

Genetics [1]

Type I hyperlipoproteinemia
  • Genetic deficiency or dysfunction of enzyme lipoprotein lipase (LPL)
  • Deficiency of apo C-II, that acts as a cofactor of LPL
  • Insulin deficiency or dysfunction in diabetes type 1 and 2 can also cause this disorder as LPL requires insulin for its full function.
Familial combined hyperlipidemia
  • Autosomal dominant disorder
  • Patients have either isolated triglyceride or LDL-c elevations or both.
  • Family history of premature coronary artery disease in 1 or more first-degree relatives
  • Family history for elevated triglycerides with or without elevated LDL-c levels.
Familial hypertriglyceridemia
  • Autosomal dominant trait
  • These patients and their families have isolated triglyceride elevations
  • Increased risk of premature coronary artery disease.

Idiopathic (constitutional)

Secondary hypertriglyceridemia

Metabolic [1]

Drugs

Miscellaneous

References

  1. 1.0 1.1 Kolovou GD, Anagnostopoulou KK, Kostakou PM, Bilianou H, Mikhailidis DP (2009). "Primary and secondary hypertriglyceridaemia". Curr Drug Targets. 10 (4): 336–43. PMID 19355858.

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