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*5% patient will have a 1 mg/dl increase of [[creatinine]] following [[angiography]]
*5% patient will have a 1 mg/dl increase of [[creatinine]] following [[angiography]]
*<1% [[chronic]] [[dialysis]]
*<1% [[chronic]] [[dialysis]]
== Etiology ==
===Causes===
Renal dysfunction following contrast administration during angiography may relate to either [[contrast induced nephropathy]] (CIN), [[cholesterol embolization syndrome]], or both.   
[[Renal dysfunction]] following [[contrast]] administration during [[angiography]] may relate to either [[contrast induced nephropathy]] ([[contrast induced nephropathy|CIN]]), [[cholesterol embolization syndrome]], or both.   
* '''Contrast Induced Nephropathy'''
* [[Contrast Induced Nephropathy]]
** The risk of CIN is dependent on the dose of the contrast agents used, hydration status at the time of the procedure, pre-existing renal function of the patient, age, hemodynamic stability, anemia, and diabetes (1, 6), and the risk for cholesterol embolization syndrome relates to catheter manipulation in an ascending or descending atherosclerotic aorta that releases cholesterol crystals (7).
** The risk of [[contrast induced nephropathy|CIN]] is dependent on the dose of the [[contrast agent]]s used, hydration status at the time of the procedure, pre-existing [[renal function]] of the patient, age, [[hemodynamic]] stability, [[anemia]], and [[diabetes]], and the risk for [[cholesterol embolization syndrome]] relates to catheter manipulation in an ascending or descending [[atherosclerotic]] [[aorta]] that releases [[cholesterol]] crystals.
** While the risk of [[hemodialysis]] is less than 3 percent in cases of uncomplicated CIN, the in-hospital mortality in the setting of hemodialysis exceeds 30 percent (5).   
** While the risk of [[hemodialysis]] is less than 3 percent in cases of uncomplicated [[contrast induced nephropathy|CIN]], the in-hospital [[mortality]] in the setting of [[hemodialysis]] exceeds 30 percent.   
==Risk Factors==
===Risk Factors===
*Prior [[renal insufficiency]]
*Prior [[renal insufficiency]]
*[[Diabetes Mellitus]]
*[[Diabetes Mellitus]]
*Dehydration before the procedure  
*[[Dehydration]] before the procedure  
*[[Congestive Heart Failure]]
*[[Congestive Heart Failure]]
*Larger volumes of contrast material
*Larger volumes of [[contrast]] material
*[[Nephrotoxic]] drugs
*[[Nephrotoxic]] drugs
*Recent (<48 hour) contrast exposure.
*Recent (<48 hour) [[contrast]] exposure.


==Toxicities Associated with Radiocontrast Agents==  
===Toxicities Associated with Radiocontrast Agents===  
*Allergic ([[anaphylactoid]]) reactions
*Allergic ([[anaphylactoid]]) reactions
**Grade I: Single episode of [[emesis]], nausea, sneezing, or [[vertigo]]
**Grade I: Single episode of [[emesis]], [[nausea]], [[sneezing]], or [[vertigo]]
**Grade II: [[Hives]], multiple episodes of emesis, fevers, or chills
**Grade II: [[Hives]], multiple episodes of [[emesis]], [[fever]]s, or [[chills]]
**Grade III: Clinical shock, [[bronchospasm]], [[laryngospasm]] or edema, loss of consciousness, hypotension, hypertension, cardiac arrhythmia, [[angioedema]], or [[pulmonary edema]]
**Grade III: Clinical [[shock]], [[bronchospasm]], [[laryngospasm]] or [[edema]], [[loss of consciousness]], [[hypotension]], [[hypertension]], [[cardiac arrhythmia]], [[angioedema]], or [[pulmonary edema]]
*Cardiovascular toxicity
*[[Cardiovascular]] [[toxicity]]
**Electrophysiologic
**[[Electrophysiologic study|Electrophysiologic]]
***[[Bradycardia]] ([[asystole]], heart block)
***[[Bradycardia]] ([[asystole]], [[heart block]])
***[[Tachycardia]] (sinus, ventricular)
***[[Tachycardia]] ([[sinus tachycardia|sinus]], [[ventricular tachycardia|ventricular]])
***[[Ventricular fibrillation]]
***[[Ventricular fibrillation]]
**Hemodynamic
**[[Hemodynamic]]
***[[Hypotension]] (cardiac depression, vasodilation)
***[[Hypotension]] ([[cardiac]] depression, [[vasodilation]])
***Heart failure (cardiac depression, increased intravascular volume)
***[[Heart failure]] (cardiac depression, increased [[intravascular]] volume)
*[[Nephrotoxicity]]
*[[Nephrotoxicity]]
*Discomfort
*Discomfort
**Nausea  
**[[Nausea]]
**Vomiting
**[[Vomiting]]
**Heat and flushing
**Heat and flushing
*[[Hyperthyroidism]]
*[[Hyperthyroidism]]
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| bgcolor="LightGreen"|<nowiki>"</nowiki>'''1.'''  Patients should be assessed for risk of [[Contrast induced nephropathy|contrast-induced acute kidney injury]]before PCI.<ref name="pmid15464318">{{cite journal |author=Mehran R, Aymong ED, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz GS, Lansky AJ, Moses JW, Stone GW, Leon MB, Dangas G |title=A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation |journal=[[Journal of the American College of Cardiology]] |volume=44 |issue=7 |pages=1393–9|year=2004 |month=October|pmid=15464318|doi=10.1016/j.jacc.2004.06.068|url=http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(04)01445-7|accessdate=2011-12-06}}</ref><ref name="pmid16461821">{{cite journal |author=Moscucci M, Rogers EK, Montoye C, Smith DE, Share D, O'Donnell M, Maxwell-Eward A, Meengs WL, De Franco AC, Patel K, McNamara R, McGinnity JG, Jani SM, Khanal S, Eagle KA |title=Association of a continuous quality improvement initiative with practice and outcome variations of contemporary percutaneous coronary interventions |journal=[[Circulation]] |volume=113 |issue=6|pages=814–22 |year=2006 |month=February|pmid=16461821 |doi=10.1161/CIRCULATIONAHA.105.541995|url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=16461821|accessdate=2011-12-06}}</ref> ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C]])''<nowiki>"</nowiki>
| bgcolor="LightGreen"|<nowiki>"</nowiki>'''1.'''  Patients should be assessed for risk of [[Contrast induced nephropathy|contrast-induced acute kidney injury]]before PCI.<ref name="pmid15464318">{{cite journal |author=Mehran R, Aymong ED, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz GS, Lansky AJ, Moses JW, Stone GW, Leon MB, Dangas G |title=A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation |journal=[[Journal of the American College of Cardiology]] |volume=44 |issue=7 |pages=1393–9|year=2004 |month=October|pmid=15464318|doi=10.1016/j.jacc.2004.06.068|url=http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(04)01445-7|accessdate=2011-12-06}}</ref><ref name="pmid16461821">{{cite journal |author=Moscucci M, Rogers EK, Montoye C, Smith DE, Share D, O'Donnell M, Maxwell-Eward A, Meengs WL, De Franco AC, Patel K, McNamara R, McGinnity JG, Jani SM, Khanal S, Eagle KA |title=Association of a continuous quality improvement initiative with practice and outcome variations of contemporary percutaneous coronary interventions |journal=[[Circulation]] |volume=113 |issue=6|pages=814–22 |year=2006 |month=February|pmid=16461821 |doi=10.1161/CIRCULATIONAHA.105.541995|url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=16461821|accessdate=2011-12-06}}</ref> ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C]])''<nowiki>"</nowiki>
|-
|-
| bgcolor="LightGreen"|<nowiki>"</nowiki>'''2.''' Patients undergoing cardiac catheterization with [[Contrast induced nephropathy#Choice of contrast agent|contrast media]] should receive adequate preparatory [[Contrast induced nephropathy#Hydration with or without bicarbonate|hydration]].<ref name="pmid15267006">{{cite journal |author=Bader BD, Berger ED, Heede MB, Silberbaur I, Duda S, Risler T, Erley CM |title=What is the best hydration regimen to prevent contrast media-induced nephrotoxicity? |journal=[[Clinical Nephrology]] |volume=62 |issue=1 |pages=1–7 |year=2004|month=July |pmid=15267006 |doi= |url=|accessdate=2011-12-06}}</ref><ref name="pmid11822926">{{cite journal |author=Mueller C, Buerkle G, Buettner HJ, Petersen J, Perruchoud AP, Eriksson U, Marsch S, Roskamm H |title=Prevention of contrast media-associated nephropathy: randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty |journal=[[Archives of Internal Medicine]]|volume=162|issue=3 |pages=329–36 |year=2002 |month=February |pmid=11822926 |doi=|url=http://archinte.ama-assn.org/cgi/pmidlookup?view=long&pmid=11822926|accessdate=2011-12-06}}</ref><ref name="pmid7969280">{{cite journal |author=Solomon R, Werner C, Mann D, D'Elia J, Silva P |title=Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by radiocontrast agents|journal=[[The New England Journal of Medicine]] |volume=331 |issue=21 |pages=1416–20 |year=1994 |month=November|pmid=7969280|doi=10.1056/NEJM199411243312104 |url=http://dx.doi.org/10.1056/NEJM199411243312104|accessdate=2011-12-06}}</ref><ref name="pmid12411756">{{cite journal |author=Trivedi HS, Moore H, Nasr S, Aggarwal K, Agrawal A, Goel P, Hewett J |title=A randomized prospective trial to assess the role of saline hydration on the development of contrast nephrotoxicity |journal=[[Nephron. Clinical Practice]]|volume=93 |issue=1 |pages=C29–34 |year=2003 |month=January |pmid=12411756 |doi= |url=|accessdate=2011-12-06}}</ref> ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: B]])''<nowiki>"</nowiki>
| bgcolor="LightGreen"|<nowiki>"</nowiki>'''2.''' Patients undergoing [[cardiac catheterization]] with [[Contrast induced nephropathy#Choice of contrast agent|contrast media]] should receive adequate preparatory [[Contrast induced nephropathy#Hydration with or without bicarbonate|hydration]].<ref name="pmid15267006">{{cite journal |author=Bader BD, Berger ED, Heede MB, Silberbaur I, Duda S, Risler T, Erley CM |title=What is the best hydration regimen to prevent contrast media-induced nephrotoxicity? |journal=[[Clinical Nephrology]] |volume=62 |issue=1 |pages=1–7 |year=2004|month=July |pmid=15267006 |doi= |url=|accessdate=2011-12-06}}</ref><ref name="pmid11822926">{{cite journal |author=Mueller C, Buerkle G, Buettner HJ, Petersen J, Perruchoud AP, Eriksson U, Marsch S, Roskamm H |title=Prevention of contrast media-associated nephropathy: randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty |journal=[[Archives of Internal Medicine]]|volume=162|issue=3 |pages=329–36 |year=2002 |month=February |pmid=11822926 |doi=|url=http://archinte.ama-assn.org/cgi/pmidlookup?view=long&pmid=11822926|accessdate=2011-12-06}}</ref><ref name="pmid7969280">{{cite journal |author=Solomon R, Werner C, Mann D, D'Elia J, Silva P |title=Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by radiocontrast agents|journal=[[The New England Journal of Medicine]] |volume=331 |issue=21 |pages=1416–20 |year=1994 |month=November|pmid=7969280|doi=10.1056/NEJM199411243312104 |url=http://dx.doi.org/10.1056/NEJM199411243312104|accessdate=2011-12-06}}</ref><ref name="pmid12411756">{{cite journal |author=Trivedi HS, Moore H, Nasr S, Aggarwal K, Agrawal A, Goel P, Hewett J |title=A randomized prospective trial to assess the role of saline hydration on the development of contrast nephrotoxicity |journal=[[Nephron. Clinical Practice]]|volume=93 |issue=1 |pages=C29–34 |year=2003 |month=January |pmid=12411756 |doi= |url=|accessdate=2011-12-06}}</ref> ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: B]])''<nowiki>"</nowiki>
|-
|-
| bgcolor="LightGreen"|<nowiki>"</nowiki>'''3.''' In patients with [[Chronic kidney disease|chronic kidney disease (CKD)]] ([[creatinine clearance]] ≤60 mL/min), the volume of [[Contrast induced nephropathy#Choice of contrast agent|contrast media]] should be minimized.<ref name="pmid19189906">{{cite journal|author=Marenzi G, Assanelli E, Campodonico J, Lauri G, Marana I, De Metrio M, Moltrasio M, Grazi M, Rubino M, Veglia F, Fabbiocchi F, Bartorelli AL |title=Contrast volume during primary percutaneous coronary intervention and subsequent contrast-induced nephropathy and mortality |journal=[[Annals of Internal Medicine]] |volume=150 |issue=3 |pages=170–7 |year=2009 |month=February |pmid=19189906 |doi=|url=|accessdate=2011-12-06}}</ref><ref name="pmid9375704">{{cite journal |author=McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW|title=Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality |journal=[[The American Journal of Medicine]]|volume=103 |issue=5 |pages=368–75 |year=1997 |month=November |pmid=9375704|doi=|url=http://linkinghub.elsevier.com/retrieve/pii/S0002-9343(97)00150-2|accessdate=2011-12-06}}</ref><ref name="pmid8589322">{{cite journal |author=Russo D, Minutolo R, Cianciaruso B, Memoli B, Conte G, De Nicola L |title=Early effects of contrast media on renal hemodynamics and tubular function in chronic renal failure |journal=[[Journal of the American Society of Nephrology : JASN]] |volume=6|issue=5 |pages=1451–8 |year=1995 |month=November|pmid=8589322 |doi= |url=http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=8589322|accessdate=2011-12-06}}</ref> ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: B]])''<nowiki>"</nowiki>
| bgcolor="LightGreen"|<nowiki>"</nowiki>'''3.''' In patients with [[Chronic kidney disease|chronic kidney disease (CKD)]] ([[creatinine clearance]] ≤60 mL/min), the volume of [[Contrast induced nephropathy#Choice of contrast agent|contrast media]] should be minimized.<ref name="pmid19189906">{{cite journal|author=Marenzi G, Assanelli E, Campodonico J, Lauri G, Marana I, De Metrio M, Moltrasio M, Grazi M, Rubino M, Veglia F, Fabbiocchi F, Bartorelli AL |title=Contrast volume during primary percutaneous coronary intervention and subsequent contrast-induced nephropathy and mortality |journal=[[Annals of Internal Medicine]] |volume=150 |issue=3 |pages=170–7 |year=2009 |month=February |pmid=19189906 |doi=|url=|accessdate=2011-12-06}}</ref><ref name="pmid9375704">{{cite journal |author=McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW|title=Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality |journal=[[The American Journal of Medicine]]|volume=103 |issue=5 |pages=368–75 |year=1997 |month=November |pmid=9375704|doi=|url=http://linkinghub.elsevier.com/retrieve/pii/S0002-9343(97)00150-2|accessdate=2011-12-06}}</ref><ref name="pmid8589322">{{cite journal |author=Russo D, Minutolo R, Cianciaruso B, Memoli B, Conte G, De Nicola L |title=Early effects of contrast media on renal hemodynamics and tubular function in chronic renal failure |journal=[[Journal of the American Society of Nephrology : JASN]] |volume=6|issue=5 |pages=1451–8 |year=1995 |month=November|pmid=8589322 |doi= |url=http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=8589322|accessdate=2011-12-06}}</ref> ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: B]])''<nowiki>"</nowiki>
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| colspan="1" style="text-align:center; background:LightCoral"|[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class III]] (No Benefit)
| colspan="1" style="text-align:center; background:LightCoral"|[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class III]] (No Benefit)
|-
|-
| bgcolor="LightCoral"|<nowiki>"</nowiki>'''1.''' Administration of N-acetyl-L-cysteine is not useful for the prevention of contrast-induced[[acute kidney injury]].<ref> Gonzales DA, Norsworthy KJ, Kern SJ, et al. A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC Med. 2007; 5: 32. Published online November 14, 2007. doi:10.1186/1741-7015-5-32</ref><ref>Ozcan EE, Guneri S, Akdeniz B, et al. Sodium bicarbonate, N-acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial. Am Heart J. 2007; 154: 539– 44.</ref> <ref>Thiele H, Hildebrand L, Schirdewahn C, et al. Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate PercutaneouS Coronary Intervention Acute Myocardial Infarction N-ACC) Trial. J Am Coll Cardiol. 2010; 55: 2201– 9.</ref><ref>Webb JG, Pate GE, Humphries KH, et al. A randomized controlled trial of intravenous N-acetylcysteine for the prevention of contrast-induced nephropathy after cardiac catheterization: lack of effect. Am Heart J. 2004; 148: 422–9.</ref><ref>ACT Investigators. Acetylcysteine for prevention of renal outcomes in patients undergoing coronary and peripheral vascular angiography: main results from the randomized Acetylcysteine for Contrast-Induced Nephropathy Trial (ACT). Circulation. 2011; 124: 1250–9.</ref> ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: A]])''<nowiki>"</nowiki>
| bgcolor="LightCoral"|<nowiki>"</nowiki>'''1.''' Administration of N-acetyl-L-[[cysteine]] is not useful for the prevention of [[contrast]]-induced[[acute kidney injury]].<ref> Gonzales DA, Norsworthy KJ, Kern SJ, et al. A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC Med. 2007; 5: 32. Published online November 14, 2007. doi:10.1186/1741-7015-5-32</ref><ref>Ozcan EE, Guneri S, Akdeniz B, et al. Sodium bicarbonate, N-acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial. Am Heart J. 2007; 154: 539– 44.</ref> <ref>Thiele H, Hildebrand L, Schirdewahn C, et al. Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate PercutaneouS Coronary Intervention Acute Myocardial Infarction N-ACC) Trial. J Am Coll Cardiol. 2010; 55: 2201– 9.</ref><ref>Webb JG, Pate GE, Humphries KH, et al. A randomized controlled trial of intravenous N-acetylcysteine for the prevention of contrast-induced nephropathy after cardiac catheterization: lack of effect. Am Heart J. 2004; 148: 422–9.</ref><ref>ACT Investigators. Acetylcysteine for prevention of renal outcomes in patients undergoing coronary and peripheral vascular angiography: main results from the randomized Acetylcysteine for Contrast-Induced Nephropathy Trial (ACT). Circulation. 2011; 124: 1250–9.</ref> ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: A]])''<nowiki>"</nowiki>
|}
|}


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| colspan="1" style="text-align:center; background:LightGreen"|[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class I]]
| colspan="1" style="text-align:center; background:LightGreen"|[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class I]]
|-
|-
| bgcolor="LightGreen"|<nowiki>"</nowiki>'''1.''' In patients undergoing PCI, the [[glomerular filtration rate]] should be estimated and the dosage of renally cleared medications should be adjusted.<ref name="pmid16908915">{{cite journal |author=Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F |title=Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate|journal=[[Annals of Internal Medicine]] |volume=145 |issue=4 |pages=247–54|year=2006 |month=August|pmid=16908915 |doi= |url= |accessdate=2011-12-15}}</ref><ref name="pmid19446939">{{cite journal|author=Stevens LA, Nolin TD, Richardson MM, Feldman HI, Lewis JB, Rodby R, Townsend R, Okparavero A, Zhang YL, Schmid CH, Levey AS |title=Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations |journal=[[American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation]] |volume=54 |issue=1 |pages=33–42 |year=2009|month=July |pmid=19446939 |pmc=2756662|doi=10.1053/j.ajkd.2009.03.008|url=http://linkinghub.elsevier.com/retrieve/pii/S0272-6386(09)00601-5|accessdate=2011-12-15}}</ref><ref name="pmid19776297">{{cite journal |author=Hassan Y, Al-Ramahi RJ, Aziz NA, Ghazali R |title=Impact of a renal drug dosing service on dose adjustment in hospitalized patients with chronic kidney disease |journal=[[The Annals of Pharmacotherapy]]|volume=43 |issue=10 |pages=1598–605|year=2009 |month=October |pmid=19776297 |doi=10.1345/aph.1M187|url=http://www.theannals.com/cgi/pmidlookup?view=long&pmid=19776297|accessdate=2011-12-15}}</ref>''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: B]])''<nowiki>"</nowiki>
| bgcolor="LightGreen"|<nowiki>"</nowiki>'''1.''' In patients undergoing PCI, the [[glomerular filtration rate]] should be estimated and the dosage of renally cleared medications should be adjusted.<ref name="pmid16908915">{{cite journal |author=Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F |title=Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate|journal=[[Annals of Internal Medicine]] |volume=145 |issue=4 |pages=247–54|year=2006 |month=August|pmid=16908915 |doi= |url= |accessdate=2011-12-15}}</ref><ref name="pmid19446939">{{cite journal|author=Stevens LA, Nolin TD, Richardson MM, Feldman HI, Lewis JB, Rodby R, Townsend R, Okparavero A, Zhang YL, Schmid CH, Levey AS |title=Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations |journal=[[American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation]] |volume=54 |issue=1 |pages=33–42 |year=2009|month=July |pmid=19446939 |pmc=2756662|doi=10.1053/j.ajkd.2009.03.008|url=http://linkinghub.elsevier.com/retrieve/pii/S0272-6386(09)00601-5|accessdate=2011-12-15}}</ref><ref name="pmid19776297">{{cite journal |author=Hassan Y, Al-Ramahi RJ, Aziz NA, Ghazali R |title=Impact of a renal drug dosing service on dose adjustment in hospitalized patients with chronic kidney disease |journal=[[The Annals of Pharmacotherapy]]|volume=43 |issue=10 |pages=1598–605|year=2009 |month=October |pmid=19776297 |doi=10.1345/aph.1M187|url=http://www.theannals.com/cgi/pmidlookup?view=long&pmid=19776297|accessdate=2011-12-15}}</ref> ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: B]])''<nowiki>"</nowiki>
|}
|}


==References==  
==References==  
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Revision as of 20:34, 10 January 2013

Percutaneous coronary intervention Microchapters

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Editors-In-Chief: Alexandra Almonacid M.D., Jeffrey J.Popma M.D.

Renal Failure

Incidence

Causes

Renal dysfunction following contrast administration during angiography may relate to either contrast induced nephropathy (CIN), cholesterol embolization syndrome, or both.

Risk Factors

Toxicities Associated with Radiocontrast Agents

2011 ACCF/AHA/SCAI Guidelines for Percutaneous Coronary Intervention (DO NOT EDIT)[1]

Contrast-Induced Acute Kidney Injury (DO NOT EDIT)[1]

Class I
"1. Patients should be assessed for risk of contrast-induced acute kidney injurybefore PCI.[2][3] (Level of Evidence: C)"
"2. Patients undergoing cardiac catheterization with contrast media should receive adequate preparatory hydration.[4][5][6][7] (Level of Evidence: B)"
"3. In patients with chronic kidney disease (CKD) (creatinine clearance ≤60 mL/min), the volume of contrast media should be minimized.[8][9][10] (Level of Evidence: B)"
Class III (No Benefit)
"1. Administration of N-acetyl-L-cysteine is not useful for the prevention of contrast-inducedacute kidney injury.[11][12] [13][14][15] (Level of Evidence: A)"

PCI in Chronic Kidney Disease (DO NOT EDIT)[1]

Class I
"1. In patients undergoing PCI, the glomerular filtration rate should be estimated and the dosage of renally cleared medications should be adjusted.[16][17][18] (Level of Evidence: B)"

References

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  8. Marenzi G, Assanelli E, Campodonico J, Lauri G, Marana I, De Metrio M, Moltrasio M, Grazi M, Rubino M, Veglia F, Fabbiocchi F, Bartorelli AL (2009). "Contrast volume during primary percutaneous coronary intervention and subsequent contrast-induced nephropathy and mortality". Annals of Internal Medicine. 150 (3): 170–7. PMID 19189906. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
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  12. Ozcan EE, Guneri S, Akdeniz B, et al. Sodium bicarbonate, N-acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial. Am Heart J. 2007; 154: 539– 44.
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  17. Stevens LA, Nolin TD, Richardson MM, Feldman HI, Lewis JB, Rodby R, Townsend R, Okparavero A, Zhang YL, Schmid CH, Levey AS (2009). "Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations". American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 54 (1): 33–42. doi:10.1053/j.ajkd.2009.03.008. PMC 2756662. PMID 19446939. Retrieved 2011-12-15. Unknown parameter |month= ignored (help)
  18. Hassan Y, Al-Ramahi RJ, Aziz NA, Ghazali R (2009). "Impact of a renal drug dosing service on dose adjustment in hospitalized patients with chronic kidney disease". The Annals of Pharmacotherapy. 43 (10): 1598–605. doi:10.1345/aph.1M187. PMID 19776297. Retrieved 2011-12-15. Unknown parameter |month= ignored (help)

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