Uveitis laboratory findings: Difference between revisions

Jump to navigation Jump to search
m (Bot: Removing from Primary care)
 
(19 intermediate revisions by 4 users not shown)
Line 3: Line 3:
{{CMG}}; {{AE}} {{TarekNafee}}
{{CMG}}; {{AE}} {{TarekNafee}}
==Overview==
==Overview==
There are no diagnostic lab findings associated with uveitis. The presence of certain non-specific laboratory findings, in the presence of uveitis, may be suggestive of certain underlying causes.
There are no diagnostic lab findings associated with uveitis. The presence of certain non-specific laboratory findings, in the presence of uveitis, may be suggestive of certain underlying causes. Examples of tests that may demonstrate abnormal findings include [[CBC]], [[ESR]], [[CRP]], complete metabolic panel, iron studies, and serology titers.<ref name="pmid23803478">{{cite journal| author=Majumder PD, Sudharshan S, Biswas J| title=Laboratory support in the diagnosis of uveitis. | journal=Indian J Ophthalmol | year= 2013 | volume= 61 | issue= 6 | pages= 269-76 | pmid=23803478 | doi=10.4103/0301-4738.114095 | pmc=3744779 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23803478  }} </ref><ref name="pmid20029142">{{cite journal| author=Agrawal RV, Murthy S, Sangwan V, Biswas J| title=Current approach in diagnosis and management of anterior uveitis. | journal=Indian J Ophthalmol | year= 2010 | volume= 58 | issue= 1 | pages= 11-9 | pmid=20029142 | doi=10.4103/0301-4738.58468 | pmc=2841369 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20029142  }} </ref><ref name="pmid23803476">{{cite journal| author=Rathinam SR, Babu M| title=Algorithmic approach in the diagnosis of uveitis. | journal=Indian J Ophthalmol | year= 2013 | volume= 61 | issue= 6 | pages= 255-62 | pmid=23803476 | doi=10.4103/0301-4738.114092 | pmc=3744777 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23803476  }} </ref><ref name="pmid20404984">{{cite journal| author=Herbort CP| title=Appraisal, work-up and diagnosis of anterior uveitis: a practical approach. | journal=Middle East Afr J Ophthalmol | year= 2009 | volume= 16 | issue= 4 | pages= 159-67 | pmid=20404984 | doi=10.4103/0974-9233.58416 | pmc=2855658 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20404984  }} </ref><ref name="pmid2178095">{{cite journal| author=Kijlstra A| title=The value of laboratory testing in uveitis. | journal=Eye (Lond) | year= 1990 | volume= 4 ( Pt 5) | issue=  | pages= 732-6 | pmid=2178095 | doi=10.1038/eye.1990.104 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2178095  }} </ref>


== Laboratory findings ==
== Laboratory findings ==
There are no diagnostic lab findings associated with uveitis. The presence of certain non-specific laboratory findings, in the presence of uveitis, may be suggestive of certain underlying causes such as:
There are no diagnostic lab findings associated with uveitis. The presence of certain non-specific laboratory findings, in the presence of uveitis, may be suggestive of certain underlying causes. Routine laboratory studies should be correlated with a carefully collected history and a precise physical examination. Routine laboratory tests that may be ordered and their respective findings include:<ref name="pmid23803478">{{cite journal| author=Majumder PD, Sudharshan S, Biswas J| title=Laboratory support in the diagnosis of uveitis. | journal=Indian J Ophthalmol | year= 2013 | volume= 61 | issue= 6 | pages= 269-76 | pmid=23803478 | doi=10.4103/0301-4738.114095 | pmc=3744779 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23803478  }} </ref><ref name="pmid20029142">{{cite journal| author=Agrawal RV, Murthy S, Sangwan V, Biswas J| title=Current approach in diagnosis and management of anterior uveitis. | journal=Indian J Ophthalmol | year= 2010 | volume= 58 | issue= 1 | pages= 11-9 | pmid=20029142 | doi=10.4103/0301-4738.58468 | pmc=2841369 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20029142  }} </ref><ref name="pmid23803476">{{cite journal| author=Rathinam SR, Babu M| title=Algorithmic approach in the diagnosis of uveitis. | journal=Indian J Ophthalmol | year= 2013 | volume= 61 | issue= 6 | pages= 255-62 | pmid=23803476 | doi=10.4103/0301-4738.114092 | pmc=3744777 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23803476  }} </ref><ref name="pmid20404984">{{cite journal| author=Herbort CP| title=Appraisal, work-up and diagnosis of anterior uveitis: a practical approach. | journal=Middle East Afr J Ophthalmol | year= 2009 | volume= 16 | issue= 4 | pages= 159-67 | pmid=20404984 | doi=10.4103/0974-9233.58416 | pmc=2855658 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20404984  }} </ref><ref name="pmid2178095">{{cite journal| author=Kijlstra A| title=The value of laboratory testing in uveitis. | journal=Eye (Lond) | year= 1990 | volume= 4 ( Pt 5) | issue=  | pages= 732-6 | pmid=2178095 | doi=10.1038/eye.1990.104 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2178095  }} </ref>
===Complete Blood Count with Differentials and Peripheral Blood Smear===
===Complete Blood Count with Differentials and Peripheral Blood Smear===
*A low hemoglobin or hematocrit with microcytosis or marginal normocytosis may be indicative of blood loss by inflammatory bowel disease, or any chronic inflammatory disorder.
*A low [[hemoglobin]] or [[hematocrit]] with microcytosis or marginal normocytosis may be indicative of blood loss by [[inflammatory bowel disease]], or any chronic inflammatory disorder.
*[[Eosinophilia]] may be suggestive of underlying parasitic infections, or sarcoidosis.
*[[Eosinophilia]] may be suggestive of underlying [[parasitic]] infections, or [[sarcoidosis]].
*Elevated [[white blood cells]] with a left shift may be suggestive of an underlying infection.
*Elevated [[white blood cells]] with a [[left shift]] may be suggestive of an underlying infection.
*Decreased white blood cell count may be indicative of an immunosuppressed state.
*Decreased [[white blood cell]] count may be indicative of an [[immunosuppressed]] state.
 
===ESR and CRP===
===ESR and CRP===
*Elevated ESR and CRP may be suggestive of an underlying infection or inflammatory condition.
*Elevated [[ESR]] and [[CRP]] may be suggestive of an underlying infection or [[Autoimmune|inflammatory condition]].
 
===Iron studies===
===Iron studies===
*Low ferritin with a high TIBC is suggestive of chronic blood loss by inflammatory bowel disease.
*Low [[ferritin]] with a high [[TIBC]] is suggestive of chronic blood loss by inflammatory bowel disease.
*High ferritin may be suggestive of anemia of chronic inflammatory conditions.
*High [[ferritin]] may be suggestive of anemia of chronic inflammatory conditions.
 
===Complete Metabolic Panel===
===Complete Metabolic Panel===
*Elevated BUN or Cr may be suggestive of renal dysfunction in [[tubulointerstitial nephritis]] with uveitis (TINU) syndrome.
*Elevated [[BUN]] or [[chromium]] may be suggestive of renal dysfunction in [[tubulointerstitial nephritis]] with uveitis (TINU) syndrome.
*Liver function tests such as AST or ALT may be elevated if [[sarcoidosis]], miliary [[tuberculosis]], or [[Behcet's disease]] affect the liver
*Liver function tests such as AST or ALT may be elevated if [[sarcoidosis]], miliary [[tuberculosis]], or [[Behcet's disease]] affect the liver
===Serology tests===
===Serology tests===
*[[HLA]] subtyping: HLA-B27, HLA-A29, HLA-B9, HLA-B15
*[[HLA]] subtyping: [[HLA-B27]], [[HLA-A29]], HLA-B9, HLA-B15
*[[Antinuclear antibody]] (ANA)
*[[Antinuclear antibody]] (ANA)
*[[Anti-neutrophil cytoplasmic antibody]] (ANCA)
*[[Anti-neutrophil cytoplasmic antibody]] (ANCA)
*[[Anti-dsDNA]]
*[[Anti-dsDNA]]
*Venereal disease research laboratory (VDRL) or Rapid Plasma Reagin (RPR) for [[syphilis]]
*[[Toxoplasma]] or [[Toxocara]] [[IgG]] or [[IgM]]
*Purified protein derivative (PPD) for [[tuberculosis]]
*Venereal disease research laboratory ([[VDRL]]) or Rapid Plasma Reagin ([[RPR]]) for [[syphilis]]
*Lyme titer
*Purified protein derivative ([[PPD]]) for [[tuberculosis]]
*HIV test
*[[Lyme]] titer
*[[HIV]] test
 
===Other Laboratory Findings===
===Other Laboratory Findings===
*Elevated levels of [[vitamin D]] or [[angiotensin converting enzyme]] (ACE) are suggestive of [[sarcoidosis]]
*Elevated levels of [[vitamin D]] or [[angiotensin converting enzyme]] (ACE) are suggestive of [[sarcoidosis]].


== References ==
== References ==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Ophthalmology]]
[[Category:Primary care]]


{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Ophthalmology]]
[[Category:FinalQCRequired]]
[[Category:Emergency mdicine]]
[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Infectious disease]]

Latest revision as of 00:37, 30 July 2020

Uveitis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Uveitis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Uveitis laboratory findings On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Uveitis laboratory findings

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Uveitis laboratory findings

CDC on Uveitis laboratory findings

Uveitis laboratory findings in the news

Blogs on Uveitis laboratory findings

Directions to Hospitals Treating Uveitis

Risk calculators and risk factors for Uveitis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Tarek Nafee, M.D. [2]

Overview

There are no diagnostic lab findings associated with uveitis. The presence of certain non-specific laboratory findings, in the presence of uveitis, may be suggestive of certain underlying causes. Examples of tests that may demonstrate abnormal findings include CBC, ESR, CRP, complete metabolic panel, iron studies, and serology titers.[1][2][3][4][5]

Laboratory findings

There are no diagnostic lab findings associated with uveitis. The presence of certain non-specific laboratory findings, in the presence of uveitis, may be suggestive of certain underlying causes. Routine laboratory studies should be correlated with a carefully collected history and a precise physical examination. Routine laboratory tests that may be ordered and their respective findings include:[1][2][3][4][5]

Complete Blood Count with Differentials and Peripheral Blood Smear

ESR and CRP

Iron studies

  • Low ferritin with a high TIBC is suggestive of chronic blood loss by inflammatory bowel disease.
  • High ferritin may be suggestive of anemia of chronic inflammatory conditions.

Complete Metabolic Panel

Serology tests

Other Laboratory Findings

References

  1. 1.0 1.1 Majumder PD, Sudharshan S, Biswas J (2013). "Laboratory support in the diagnosis of uveitis". Indian J Ophthalmol. 61 (6): 269–76. doi:10.4103/0301-4738.114095. PMC 3744779. PMID 23803478.
  2. 2.0 2.1 Agrawal RV, Murthy S, Sangwan V, Biswas J (2010). "Current approach in diagnosis and management of anterior uveitis". Indian J Ophthalmol. 58 (1): 11–9. doi:10.4103/0301-4738.58468. PMC 2841369. PMID 20029142.
  3. 3.0 3.1 Rathinam SR, Babu M (2013). "Algorithmic approach in the diagnosis of uveitis". Indian J Ophthalmol. 61 (6): 255–62. doi:10.4103/0301-4738.114092. PMC 3744777. PMID 23803476.
  4. 4.0 4.1 Herbort CP (2009). "Appraisal, work-up and diagnosis of anterior uveitis: a practical approach". Middle East Afr J Ophthalmol. 16 (4): 159–67. doi:10.4103/0974-9233.58416. PMC 2855658. PMID 20404984.
  5. 5.0 5.1 Kijlstra A (1990). "The value of laboratory testing in uveitis". Eye (Lond). 4 ( Pt 5): 732–6. doi:10.1038/eye.1990.104. PMID 2178095.

Template:WH Template:WS