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==Overview==
==Overview==
<br />
NK cell lymphoma shows a poor [[prognosis]] because of rapid local progression and distant [[metastasis]].The [[median]] age of onset is approximately 50 years and it is common in elderly. [[extranodal NK/T-cell lymphoma]] is a rare disease in children and often it is associated with mosquito-bite [[hypersensitivity]] or other [[EBV]]-associated disease[[Natural Killer cell|.Natural Killer (NK) cell]] lymphoma is a rare disease. [[Extranodal NK-T-cell lymphoma|extranodal NK/T cell lymphoma]], nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of [[non-Hodgkin lymphoma]] in Asia and South America and less than 1000 in 10000 patient in western countries<br />


== Epidemiology and Demographics ==
== Epidemiology and Demographics ==


=== Incidence ===
=== Mortality rate ===
Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have higher incidence in Asia , Central, and South America.<ref name="pmid23816348">{{cite journal| author=Lima M| title=Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis. | journal=Orphanet J Rare Dis | year= 2013 | volume= 8 | issue= | pages= 95 | pmid=23816348 | doi=10.1186/1750-1172-8-95 | pmc=3770456 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23816348  }} </ref>
 
* NK cell lymphoma shows a poor [[prognosis]] because of rapid local progression and distant [[Metastasis - brain|metastasis]].<ref name="JaffeNicolae2013">{{cite journal|last1=Jaffe|first1=Elaine S|last2=Nicolae|first2=Alina|last3=Pittaluga|first3=Stefania|title=Peripheral T-cell and NK-cell lymphomas in the WHO classification: pearls and pitfalls|journal=Modern Pathology|volume=26|issue=S1|year=2013|pages=S71–S87|issn=0893-3952|doi=10.1038/modpathol.2012.181}}</ref>
 
=== Age ===
 
* The [[median]] age of onset is approximately 50 years and it is common in the elderly.
*[[Extranodal NK-T-cell lymphoma|Extranodal NK/T-cell lymphoma]] is a rare disease in children and often it is associated with mosquito-bite [[hypersensitivity]] or other [[Epstein Barr virus|EBV]]-associated disease.<ref name="HarabuchiTakahara2019">{{cite journal|last1=Harabuchi|first1=Yasuaki|last2=Takahara|first2=Miki|last3=Kishibe|first3=Kan|last4=Nagato|first4=Toshihiro|last5=Kumai|first5=Takumi|title=Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: Basic Science and Clinical Progress|journal=Frontiers in Pediatrics|volume=7|year=2019|issn=2296-2360|doi=10.3389/fped.2019.00141}}</ref>
 
 
=== Race ===
 
*[[Natural killer cell|Natural Killer (NK) cell]] lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.
* Nk cell lymphoma is usually associated with [[Epstein Barr virus|Epstein-Barr virus]] infection.<ref name="Lima2013">{{cite journal|last1=Lima|first1=Margarida|title=Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis|journal=Orphanet Journal of Rare Diseases|volume=8|issue=1|year=2013|pages=95|issn=1750-1172|doi=10.1186/1750-1172-8-95}}</ref>
 
 
=== Gender ===
 
*[[Extranodal NK-T-cell lymphoma|Extranodal NK/T-cell lymphoma]] shows male preponderance.<ref name="WangGong2017">{{cite journal|last1=Wang|first1=Xiaotian|last2=Gong|first2=Zimu|last3=Li|first3=Shawn Xiang|last4=Yan|first4=Wei|last5=Song|first5=Yongsheng|title=Extranodal nasal-type natural killer/T-cell lymphoma with penile involvement: a case report and review of the literature|journal=BMC Urology|volume=17|issue=1|year=2017|issn=1471-2490|doi=10.1186/s12894-017-0273-8}}</ref>
 
 
=== Region ===
 
*[[Extranodal NK-T-cell lymphoma|Extranodal NK T cell lymphoma]], nasal type (NNKTL) consist 3000-10000 out of 100000 cases of [[non-Hodgkin lymphoma]] in Asia and South America and less than 1000 in 10000 patient in western countries.
*It is estimated the incidence of NNKTL is higher in Asia by 10-folds.<ref name="HaverkosPan2016">{{cite journal|last1=Haverkos|first1=Bradley M.|last2=Pan|first2=Zenggang|last3=Gru|first3=Alejandro A.|last4=Freud|first4=Aharon G.|last5=Rabinovitch|first5=Rachel|last6=Xu-Welliver|first6=Meng|last7=Otto|first7=Brad|last8=Barrionuevo|first8=Carlos|last9=Baiocchi|first9=Robert A.|last10=Rochford|first10=Rosemary|last11=Porcu|first11=Pierluigi|title=Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases|journal=Current Hematologic Malignancy Reports|volume=11|issue=6|year=2016|pages=514–527|issn=1558-8211|doi=10.1007/s11899-016-0355-9}}</ref>
 
 
== References ==
<references />

Latest revision as of 13:27, 28 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

NK cell lymphoma shows a poor prognosis because of rapid local progression and distant metastasis.The median age of onset is approximately 50 years and it is common in elderly. extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensitivity or other EBV-associated disease.Natural Killer (NK) cell lymphoma is a rare disease. extranodal NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of non-Hodgkin lymphoma in Asia and South America and less than 1000 in 10000 patient in western countries

Epidemiology and Demographics

Mortality rate

Age


Race

  • Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.
  • Nk cell lymphoma is usually associated with Epstein-Barr virus infection.[3]


Gender


Region

  • Extranodal NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of non-Hodgkin lymphoma in Asia and South America and less than 1000 in 10000 patient in western countries.
  • It is estimated the incidence of NNKTL is higher in Asia by 10-folds.[5]


References

  1. Jaffe, Elaine S; Nicolae, Alina; Pittaluga, Stefania (2013). "Peripheral T-cell and NK-cell lymphomas in the WHO classification: pearls and pitfalls". Modern Pathology. 26 (S1): S71–S87. doi:10.1038/modpathol.2012.181. ISSN 0893-3952.
  2. Harabuchi, Yasuaki; Takahara, Miki; Kishibe, Kan; Nagato, Toshihiro; Kumai, Takumi (2019). "Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: Basic Science and Clinical Progress". Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00141. ISSN 2296-2360.
  3. Lima, Margarida (2013). "Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis". Orphanet Journal of Rare Diseases. 8 (1): 95. doi:10.1186/1750-1172-8-95. ISSN 1750-1172.
  4. Wang, Xiaotian; Gong, Zimu; Li, Shawn Xiang; Yan, Wei; Song, Yongsheng (2017). "Extranodal nasal-type natural killer/T-cell lymphoma with penile involvement: a case report and review of the literature". BMC Urology. 17 (1). doi:10.1186/s12894-017-0273-8. ISSN 1471-2490.
  5. Haverkos, Bradley M.; Pan, Zenggang; Gru, Alejandro A.; Freud, Aharon G.; Rabinovitch, Rachel; Xu-Welliver, Meng; Otto, Brad; Barrionuevo, Carlos; Baiocchi, Robert A.; Rochford, Rosemary; Porcu, Pierluigi (2016). "Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases". Current Hematologic Malignancy Reports. 11 (6): 514–527. doi:10.1007/s11899-016-0355-9. ISSN 1558-8211.