Extranodal NK-T-cell lymphoma staging
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Extranodal NK-T-cell lymphoma Microchapters |
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Differentiating Extranodal NK-T-cell lymphoma from other Diseases |
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Risk calculators and risk factors for Extranodal NK-T-cell lymphoma staging |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Extranodal NK/T cell lymphoma survival rate is not well predicted by Ann Arbor staging system. A new system was introduced based on B symptoms, Ann Arbor system, LDH level, and regional lymphadenopathy combined. Another parallel mechanism for extranodal NK/T cell lymphoma is based on tumor biologic and micro-environmental factors. High Ki-67 nuclear antigen is a marker for actively proliferation tumor cell which could be a related factor with mass bulk.
Staging
- Extranodal NK/T cell lymphoma survival rate is not well predicted by Ann Arbor staging system[1]|[2].
- A new system was introduced by a Korean study based on B symptoms, Ann Arbor system, LDH level, and regional lymphadenopathy combined.Four risk groups identified as below:
- group 1: No adverse factor
- group 2: One factor
- group 3: Two factors
- group 4: Three or more factors
| Group | Altered factors count | 5 year prognosis |
|---|---|---|
| 1 | N.O. | 81000 out of 100000 |
| 2 | 1 | 64000 out of 100000 |
| 3 | 2 | 34000 out of 100000 |
| 4 | 3/More | 7000 out of 100000 |
- Another parallel mechanism for extranodal NK/T cell lymphoma is based on tumor biologic and micro-environmental factors. High Ki-67 nuclear antigen is a marker for actively proliferation tumor cell which could be a related factor with mass bulk.
References
- ↑ Jaffe ES, Krenacs L, Raffeld M (2003). "Classification of cytotoxic T-cell and natural killer cell lymphomas". Semin Hematol. 40 (3): 175–84. PMID 12876666.
- ↑ Feller AC (2003). "[Classification and differential diagnosis of NK/T-cell lymphomas]". Verh Dtsch Ges Pathol. 87: 43–52. PMID 16888893.