MiR-134: Difference between revisions

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miR-134 is a brain-specific microRNA; in rats it is localised specifically in [[Hippocampus|hippocampal neurons]] and may indirectly regulate [[synapse|synaptic development]] through [[antisense RNA|antisense pairing]] with [[LIMK1]] mRNA.<ref>{{cite journal|last=Schratt|first=GM|author2=Tuebing, F |author3=Nigh, EA |author4=Kane, CG |author5=Sabatini, ME |author6=Kiebler, M |author7=Greenberg, ME |title=A brain-specific microRNA regulates dendritic spine development.|journal=Nature|date=Jan 19, 2006|volume=439|issue=7074|pages=283–9|pmid=16421561|doi=10.1038/nature04367}}</ref><ref>{{cite journal|last=Tai|first=HC|author2=Schuman, EM|title=MicroRNA: microRNAs reach out into dendrites.|journal=Current Biology|date=Feb 21, 2006|volume=16|issue=4|pages=R121-3|pmid=16488859|doi=10.1016/j.cub.2006.02.006}}</ref> In the human brain, [[SIRT1]] is thought to mediate [[CREB]] protein through miR-134, giving the microRNA a role in higher brain functions such a [[memory]] formation.<ref>{{cite journal|last=Gao|first=J |author2=Wang, WY |author3=Mao, YW |author4=Gräff, J |author5=Guan, JS |author6=Pan, L |author7=Mak, G |author8=Kim, D |author9=Su, SC |author10=Tsai, LH|title=A novel pathway regulates memory and plasticity via SIRT1 and miR-134.|journal=Nature|date=Aug 26, 2010|volume=466|issue=7310|pages=1105–9|pmid=20622856|doi=10.1038/nature09271|pmc=2928875}}</ref>
miR-134 is a brain-specific microRNA; in rats it is localised specifically in [[Hippocampus|hippocampal neurons]] and may indirectly regulate [[synapse|synaptic development]] through [[antisense RNA|antisense pairing]] with [[LIMK1]] mRNA.<ref>{{cite journal|last=Schratt|first=GM|author2=Tuebing, F |author3=Nigh, EA |author4=Kane, CG |author5=Sabatini, ME |author6=Kiebler, M |author7=Greenberg, ME |title=A brain-specific microRNA regulates dendritic spine development.|journal=Nature|date=Jan 19, 2006|volume=439|issue=7074|pages=283–9|pmid=16421561|doi=10.1038/nature04367}}</ref><ref>{{cite journal|last=Tai|first=HC|author2=Schuman, EM|title=MicroRNA: microRNAs reach out into dendrites.|journal=Current Biology|date=Feb 21, 2006|volume=16|issue=4|pages=R121-3|pmid=16488859|doi=10.1016/j.cub.2006.02.006}}</ref> In the human brain, [[SIRT1]] is thought to mediate [[CREB]] protein through miR-134, giving the microRNA a role in higher brain functions such a [[memory]] formation.<ref>{{cite journal|last=Gao|first=J |author2=Wang, WY |author3=Mao, YW |author4=Gräff, J |author5=Guan, JS |author6=Pan, L |author7=Mak, G |author8=Kim, D |author9=Su, SC |author10=Tsai, LH|title=A novel pathway regulates memory and plasticity via SIRT1 and miR-134.|journal=Nature|date=Aug 26, 2010|volume=466|issue=7310|pages=1105–9|pmid=20622856|doi=10.1038/nature09271|pmc=2928875}}</ref>


miR-134 has also been reported to function in mouse [[embryonic stem cell]]s as part of a complex network regulating their differentiation.<ref>{{cite journal|last=Tay|first=YM |author2=Tam, WL |author3=Ang, YS |author4=Gaughwin, PM |author5=Yang, H |author6=Wang, W |author7=Liu, R |author8=George, J |author9=Ng, HH |author10=Perera, RJ |author11=Lufkin, T |author12=Rigoutsos, I |author13=Thomson, AM |author14=Lim, B|title=MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1.|journal=Stem cells (Dayton, Ohio)|date=Jan 2008|volume=26|issue=1|pages=17–29|pmid=17916804|doi=10.1634/stemcells.2007-0295}}</ref>
miR-134 has also been reported to function in mouse [[embryonic stem cell]]s as part of a complex network regulating their differentiation.<ref>{{cite journal|last=Tay|first=YM |author2=Tam, WL |author3=Ang, YS |author4=Gaughwin, PM |author5=Yang, H |author6=Wang, W |author7=Liu, R |author8=George, J |author9=Ng, HH |author10=Perera, RJ |author11=Lufkin, T |author12=Rigoutsos, I |author13=Thomson, AM |author14=Lim, B|title=MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1.|journal=Stem Cells|date=Jan 2008|volume=26|issue=1|pages=17–29|pmid=17916804|doi=10.1634/stemcells.2007-0295}}</ref>


==Applications==
==Applications==

Latest revision as of 06:18, 10 January 2019

miR-134
File:Mir-134 SS.png
Conserved secondary structure of miR-134
Identifiers
Symbolmir-134
Alt. SymbolsMIR134
RfamRF00699
miRBaseMI0000474
miRBase familyMIPF0000112
Entrez406924
HUGO31519
Other data
Domain(s)Mammalia
GO0035195
SO0001244
LocusChr. 14 [1]
PDB structuresPDBe

miR-134 is a family of microRNA precursors found in mammals, including humans.[1] MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product.[2] The excised region or, mature product, of the miR-134 precursor is the microRNA mir-134.

miR-134 was one of a number of microRNAs found to be increasingly expressed in schizophrenia.[3]

Functions

miR-134 is a brain-specific microRNA; in rats it is localised specifically in hippocampal neurons and may indirectly regulate synaptic development through antisense pairing with LIMK1 mRNA.[4][5] In the human brain, SIRT1 is thought to mediate CREB protein through miR-134, giving the microRNA a role in higher brain functions such a memory formation.[6]

miR-134 has also been reported to function in mouse embryonic stem cells as part of a complex network regulating their differentiation.[7]

Applications

miR-134 levels in circulating blood could potentially be used as a peripheral biomarker for bipolar disorder.[8]

References

  1. ↑ Landgraf, P; Rusu, M; Sheridan, R; Sewer, A; Iovino, N; Aravin, A; Pfeffer, S; Rice, A; et al. (Jun 29, 2007). "A mammalian microRNA expression atlas based on small RNA library sequencing". Cell. 129 (7): 1401–14. doi:10.1016/j.cell.2007.04.040. PMC 2681231. PMID 17604727.
  2. ↑ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823&ndash, 826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
  3. ↑ Santarelli, DM; Beveridge, NJ; Tooney, PA; Cairns, MJ (Jan 15, 2011). "Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia". Biological Psychiatry. 69 (2): 180–7. doi:10.1016/j.biopsych.2010.09.030. PMID 21111402.
  4. ↑ Schratt, GM; Tuebing, F; Nigh, EA; Kane, CG; Sabatini, ME; Kiebler, M; Greenberg, ME (Jan 19, 2006). "A brain-specific microRNA regulates dendritic spine development". Nature. 439 (7074): 283–9. doi:10.1038/nature04367. PMID 16421561.
  5. ↑ Tai, HC; Schuman, EM (Feb 21, 2006). "MicroRNA: microRNAs reach out into dendrites". Current Biology. 16 (4): R121–3. doi:10.1016/j.cub.2006.02.006. PMID 16488859.
  6. ↑ Gao, J; Wang, WY; Mao, YW; Gräff, J; Guan, JS; Pan, L; Mak, G; Kim, D; Su, SC; Tsai, LH (Aug 26, 2010). "A novel pathway regulates memory and plasticity via SIRT1 and miR-134". Nature. 466 (7310): 1105–9. doi:10.1038/nature09271. PMC 2928875. PMID 20622856.
  7. ↑ Tay, YM; Tam, WL; Ang, YS; Gaughwin, PM; Yang, H; Wang, W; Liu, R; George, J; Ng, HH; Perera, RJ; Lufkin, T; Rigoutsos, I; Thomson, AM; Lim, B (Jan 2008). "MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1". Stem Cells. 26 (1): 17–29. doi:10.1634/stemcells.2007-0295. PMID 17916804.
  8. ↑ Rong, H; Liu, TB; Yang, KJ; Yang, HC; Wu, DH; Liao, CP; Hong, F; Yang, HZ; Wan, F; Ye, XY; Xu, D; Zhang, X; Chao, CA; Shen, QJ (Jan 2011). "MicroRNA-134 plasma levels before and after treatment for bipolar mania". Journal of Psychiatric Research. 45 (1): 92–5. doi:10.1016/j.jpsychires.2010.04.028. PMID 20546789.

External links

Retrieved from "https://www.wikidoc.org/index.php?title=MiR-134&oldid=1521237"