The miR-10 microRNA precursor, is a short non-coding RNA gene involved in gene regulation. It is also part of an RNA gene family which contains miR-10, miR-51, miR-57, miR-99 and miR-100. miR-10, miR-99 and miR-100 have now been predicted or experimentally confirmed in a wide range of species (MIPF0000033, MIPF0000025). mir-51 and mir-57 have currently only been identified in the nematode Caenorhabditis elegans (MIPF0000268, MIPF0000271). microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.
↑Lee, RC (2001). "An extensive class of small RNAs in Caenorhabditis elegans". Science. 294: 862&ndash, 864. PMID 11679672. Unknown parameter |coauthors= ignored (help)
↑Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell. 107: 823&ndash, 826. PMID 11779458.