Mir-10 microRNA precursor family

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mir-10 microRNA precursor family
Template:Abbreviation
Type: Gene; miRNA;
2° structure: Predicted; PFOLD
Seed alignment: Griffiths-Jones SR
Avg length: 73.8 nucleotides
Avg identity: 67%

The miR-10 microRNA precursor, is a short non-coding RNA gene involved in gene regulation. It is also part of an RNA gene family which contains miR-10, miR-51, miR-57, miR-99 and miR-100. miR-10, miR-99 and miR-100 have now been predicted or experimentally confirmed in a wide range of species[1][2] (MIPF0000033, MIPF0000025). mir-51 and mir-57 have currently only been identified in the nematode Caenorhabditis elegans (MIPF0000268, MIPF0000271). microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.

References

  1. Lee, RC (2001). "An extensive class of small RNAs in Caenorhabditis elegans". Science. 294: 862&ndash, 864. PMID 11679672. Unknown parameter |coauthors= ignored (help)
  2. Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell. 107: 823&ndash, 826. PMID 11779458.

External links


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