Multiple endocrine neoplasia type 2 other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Other diagnostic studies for multiple endocrine neoplasia type 2 include molecular [[genetic testing]] which include sequence analysis of select exons of mainly 10,11, 13-16 and sequence analysis of [[RET proto-oncogene|''RET'' gene]]. | |||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Molecular Genetic Testing=== | ===Molecular Genetic Testing=== | ||
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center | |||
|+'''''Molecular genetic testing''''' | |||
! style="background: #4479BA; width: 120px;" | {{fontcolor|#FFF|Test}} | |||
! style="background: #4479BA; width: 550px;" | {{fontcolor|#FFF|Method}} | |||
|- | |||
! style="background: #F5F5F5;" |Select exon testing | |||
! style="background: #F5F5F5;" |Sequence analysis of select exons of mainly 10,11, 13-16 | |||
|- | |||
! style="background: #F5F5F5;" |Single-gene testing | |||
! style="background: #F5F5F5;" |Sequence analysis of [[RET proto-oncogene|''RET'']] gene | |||
|- | |||
! style="background: #F5F5F5;" |A multi-gene panel | |||
! style="background: #F5F5F5;" |[[RET proto-oncogene|''RET'']] and other genes of interest | |||
|} | |||
===Histopathological Staining of the Biopsy=== | |||
* Histopathological staining of medullary thyroid cancer<ref>{{Cite journal| author = [[Jessica Marquard]] & [[Charis Eng]] | |||
| title = Multiple Endocrine Neoplasia Type 2 | |||
| year = 1993 | |||
| month = | |||
| pmid = 020301434 | |||
}}</ref> | |||
# [[Calcitonin]]: positive in [[tumor]] [[cell]]s | |||
# [[Chromogranin]]: positive in [[tumor]] [[cell]]s | |||
# [[Synaptophysin]]: positive in [[tumor]] [[cell]]s | |||
==References== | |||
{{reflist|2}} | |||
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Latest revision as of 02:47, 27 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Other diagnostic studies for multiple endocrine neoplasia type 2 include molecular genetic testing which include sequence analysis of select exons of mainly 10,11, 13-16 and sequence analysis of RET gene.
Other Diagnostic Studies
Molecular Genetic Testing
Test | Method |
---|---|
Select exon testing | Sequence analysis of select exons of mainly 10,11, 13-16 |
Single-gene testing | Sequence analysis of RET gene |
A multi-gene panel | RET and other genes of interest |
Histopathological Staining of the Biopsy
- Histopathological staining of medullary thyroid cancer[1]
- Calcitonin: positive in tumor cells
- Chromogranin: positive in tumor cells
- Synaptophysin: positive in tumor cells
References
- ↑ Jessica Marquard & Charis Eng (1993). "Multiple Endocrine Neoplasia Type 2". PMID 020301434.