Von Willebrand disease epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2]
Overview
The prevalence of von Willebrand’s disease is 0.6 to 1.3%. It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons. The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population. The symptoms of VWD is disproportionately more common in women of child-bearing age. Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during menstruation. There is no racial predilection to vWD however, it may be more severe or apparent in people with blood type O.
Epidemiology and Demographics
Prevalence
The prevalence of von Willebrand’s disease is 0.6 to 1.3%.[1][2] It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons.[3]
The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population.
Age
The symptoms of VWD is disproportionately more common in women of child-bearing age.[1]
Gender
Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during menstruation.[4][5]
Race
There is no racial predilection to vWD however, it may be more severe or apparent in people with blood type O.[6]
References
- ↑ 1.0 1.1 Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL; et al. (2008). "von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)". Haemophilia. 14 (2): 171–232. doi:10.1111/j.1365-2516.2007.01643.x. PMID 18315614.
- ↑ Rodeghiero F, Castaman G, Dini E (1987). "Epidemiological investigation of the prevalence of von Willebrand's disease". Blood. 69 (2): 454–9. PMID 3492222.
- ↑ Sadler JE, Mannucci PM, Berntorp E, Bochkov N, Boulyjenkov V, Ginsburg D; et al. (2000). "Impact, diagnosis and treatment of von Willebrand disease". Thromb Haemost. 84 (2): 160–74. PMID 10959685.
- ↑ Lee CA (1999). "Women and inherited bleeding disorders: menstrual issues". Semin Hematol. 36 (3 Suppl 4): 21–7. PMID 10513768.
- ↑ Miller CH, Philipp CS, Stein SF, Kouides PA, Lukes AS, Heit JA; et al. (2011). "The spectrum of haemostatic characteristics of women with unexplained menorrhagia". Haemophilia. 17 (1): e223–9. doi:10.1111/j.1365-2516.2010.02382.x. PMID 21040234.
- ↑ Gill JC, Endres-Brooks J, Bauer PJ, Marks WJ, Montgomery RR (1987). "The effect of ABO blood group on the diagnosis of von Willebrand disease". Blood. 69 (6): 1691–5. PMID 3495304.