Vault RNA
Jump to navigation
Jump to search
Vault RNAs are an RNA family found as part of the vault ribonucleoprotein complex first discovered in 1986. The complex consists of a major vault protein (MVP), two minor vault proteins (VPARP and TEP1), and several small untranslated RNA molecules. Each vault particle contains 16 vRNA molecules. It has been suggested that the vault complex is involved in drug resistance [1]
Species distribution
Vault RNAs have been found in:
- Human
- Rodents
- Bullfrog
Vaults but not the vRNA have also been isolated[2] from:
- sea urchin
- Dictyostelium
- Acanthamoeba
References
- ↑ Scheffer GL, Wijngaard PLJ, Flens MJ, Izquierdo MA, Slovak M, Meijer C, Clevers HC and Scheper RJ (1995). "The Drug Resistance-Related Protein Lrp Is the Human Major Vault Protein". Nature Medicine. 1: 578–582. Unknown parameter
|pubmed=ignored (help) - ↑ Kedersha NL, Miquel MC, Bittner D, Rome LH (1990). "Vaults. II. Ribonucleoprotein structures are highly conserved among higher and lower eukaryotes". J Cell Biol. 110: 895–901. Unknown parameter
|pubmed=ignored (help)
External links
 | This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |