Ubiquitin-calmodulin ligase

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In enzymology, an ubiquitin-calmodulin ligase (EC is an enzyme that catalyzes the chemical reaction

n ATP + calmodulin + n ubiquitin n AMP + n diphosphate + (ubiquitin)n-calmodulin

The 3 substrates of this enzyme are ATP, calmodulin, and ubiquitin, whereas its 3 products are AMP, diphosphate, and (ubiquitin)n-calmodulin.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is calmodulin:ubiquitin ligase (AMP-forming). Other names in common use include ubiquityl-calmodulin synthase, ubiquitin-calmodulin synthetase, ubiquityl-calmodulin synthetase, and uCaM-synthetase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Jennissen HP, Laub M (1988). "Ubiquitin-calmodulin conjugating activity from cardiac muscle". Biol. Chem. Hoppe. Seyler. 369: 1325&ndash, 30. PMID 2853950.
  • Ziegenhagen R, Jennissen HP (1988). "Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase". Biol. Chem. Hoppe. Seyler. 369: 1317&ndash, 24. PMID 2853949.

External links

The CAS registry number for this enzyme class is 119632-60-9.

Gene Ontology (GO) codes