UDP-N-acetylglucosamine 4-epimerase

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In enzymology, an UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine UDP-N-acetyl-D-galactosamine

Hence, this enzyme has one substrate, UDP-N-acetyl-D-glucosamine, and one product, UDP-N-acetyl-D-galactosamine.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine 4-epimerase. Other names in common use include UDP acetylglucosamine epimerase, uridine diphosphoacetylglucosamine epimerase, uridine diphosphate N-acetylglucosamine-4-epimerase, and uridine 5'-diphospho-N-acetylglucosamine-4-epimerase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1SB8 and 1SB9.

References

  • IUBMB entry for 5.1.3.7
  • BRENDA references for 5.1.3.7 (Recommended.)
  • PubMed references for 5.1.3.7
  • PubMed Central references for 5.1.3.7
  • Google Scholar references for 5.1.3.7
  • GLASER L (1959). "The biosynthesis of N-acetylgalactosamine". J. Biol. Chem. 234: 2801&ndash, 5. PMID 13828347.
  • Kornfeld S and Glaser L (1962). "The synthesis of thymidine-linked sugars. V. Thymidine diphosphate-amino sugars". J. Biol. Chem. 237: 3052&ndash, 3059.

External links

The CAS registry number for this enzyme class is 9024-16-2.

Gene Ontology (GO) codes



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