Tyrosine-arginine ligase

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In enzymology, a tyrosine-arginine ligase (EC is an enzyme that catalyzes the chemical reaction

ATP + L-tyrosine + L-arginine AMP + diphosphate + L-tyrosyl-L-arginine

The 3 substrates of this enzyme are ATP, L-tyrosine, and L-arginine, whereas its 3 products are AMP, diphosphate, and L-tyrosyl-L-arginine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-tyrosine:L-arginine ligase (AMP-forming). Other names in common use include tyrosyl-arginine synthase, kyotorphin synthase, kyotorphin-synthesizing enzyme, and kyotorphin synthetase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Ueda H, Yoshihara Y, Fukushima N, Shiomi H, Nakamura A, Takagi H (1987). "Kyotorphin (tyrosine-arginine) synthetase in rat brain synaptosomes". J. Biol. Chem. 262: 8165&ndash, 73. PMID 3597366.

External links

The CAS registry number for this enzyme class is 116036-78-3.

Gene Ontology (GO) codes