Trichinosis medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Danitza Lukac
Overview
The mainstay of therapy for trichinosis are anthelmintics drugs such as albendazole or mebendazole.[1]
Medical Therapy
Treatment for asymptomatic, abortive and mild patients:
- Administration of anthelmintics
- Administration of glucocorticoids if needed.
Treatment for pronounced and severe patients:
- Hospitalization
- Compulsory for severe cases
- Administration of glucocorticoids, anthelmintics and analgesics.
- Administration of fluids and electrolytes [2]
Antihelmintic Regimen[1]
- Trichinosis in adult and children ≥2yrs of age
- Preferred regimen (1): Albendazole 400 mg PO bid for 8 to 14 days OR Mebendazole 200-400 mg PO tid for 3 days, then 400-500 mg PO tid for 10 days
- Note:
- Albendazole:
- Pregnancy: Albendazole is pregnancy category C.
- Lactation: It is not known whether albendazole is excreted in human milk.
- Pedriatic patients: The safety of albendazole in children less than 6 years old is not certain. Studies of the use of albendazole in children as young as one year old suggest that its use is safe.
- Mebendazole:
- Pregnancy: Mebendazole is in pregnancy category C.
- Lactation: It is not known whether mebendazole is excreted in breast milk. The WHO classifies mebendazole as compatible with breastfeeding and allows the use of mebendazole in lactating women.
- Pedriatic patients: The safety of mebendazole in children has not been established.
- Albendazole:
- Trichinosis in adult and children ≥2yrs of age
References
- ↑ 1.0 1.1 Trichinellosis. CDC. http://www.cdc.gov/parasites/trichinellosis/health_professionals/index.html#tx. Accessed on January 26, 2016
- ↑ Gottstein B, Pozio E, Nöckler K (2009). "Epidemiology, diagnosis, treatment, and control of trichinellosis". Clin Microbiol Rev. 22 (1): 127–45, Table of Contents. doi:10.1128/CMR.00026-08. PMC 2620635. PMID 19136437.