Tosyl phenylalanyl chloromethyl ketone

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Tosyl phenylalanyl chloromethyl ketone
CAS number 402-71-1
PubChem 439647
MeSH Tosylphenylalanyl+Chloromethyl+Ketone
Molecular formula C17H18ClNO3S
Molar mass 351.848 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Tosyl phenylalanyl chloromethyl ketone (TPCK) is a protease inhibitor. Its structural formula is 1-chloro-3-tosylamido-4-phenyl-2-butanone.

TPCK is the irreversible inhibitor of chymotrypsin. Also inhibits some cysteine proteases such as papain, bromelain or ficin. It does not inhibit trypsin nor zymogens.

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