Jump to: navigation, search

WikiDoc Resources for Thiostrepton


Most recent articles on Thiostrepton

Most cited articles on Thiostrepton

Review articles on Thiostrepton

Articles on Thiostrepton in N Eng J Med, Lancet, BMJ


Powerpoint slides on Thiostrepton

Images of Thiostrepton

Photos of Thiostrepton

Podcasts & MP3s on Thiostrepton

Videos on Thiostrepton

Evidence Based Medicine

Cochrane Collaboration on Thiostrepton

Bandolier on Thiostrepton

TRIP on Thiostrepton

Clinical Trials

Ongoing Trials on Thiostrepton at Clinical

Trial results on Thiostrepton

Clinical Trials on Thiostrepton at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Thiostrepton

NICE Guidance on Thiostrepton


FDA on Thiostrepton

CDC on Thiostrepton


Books on Thiostrepton


Thiostrepton in the news

Be alerted to news on Thiostrepton

News trends on Thiostrepton


Blogs on Thiostrepton


Definitions of Thiostrepton

Patient Resources / Community

Patient resources on Thiostrepton

Discussion groups on Thiostrepton

Patient Handouts on Thiostrepton

Directions to Hospitals Treating Thiostrepton

Risk calculators and risk factors for Thiostrepton

Healthcare Provider Resources

Symptoms of Thiostrepton

Causes & Risk Factors for Thiostrepton

Diagnostic studies for Thiostrepton

Treatment of Thiostrepton

Continuing Medical Education (CME)

CME Programs on Thiostrepton


Thiostrepton en Espanol

Thiostrepton en Francais


Thiostrepton in the Marketplace

Patents on Thiostrepton

Experimental / Informatics

List of terms related to Thiostrepton

Thiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of strepromycetes, such as Streptomyces azureus, Streptomyces laurentii.


  • Synonyms: Alaninamide, Bryamycin , Thiactin
  • CAS number: 1393-48-2
  • Merck index: 14: 9364
  • Molecular weight: 1664.89
  • Molecular Formula: C72H85N19O18S5
  • Melting point: decomposes at 246-256oC
  • Solubility information: Soluble in chloroform, dichloromethane, dioxane, pyridine, glacial acetic acid, DMF. Practically insoluble in water, the lower alcohols, nonpolar organic solvents, diluted aqeous acids or bases. May be dissolved by methanolic acid or base, but with decomposition. Working solution of 1% in DMSO is unstable and should be freshly prepared and protected from light.
  • Appearance: White to off-white powder


Thiostrepton was discovered by DONOVICK R, PAGANO JF, STOUT HA, WEINSTEIN MJ. in 1955 (Antibiot Annu. 1955-1956;3:554-9), who desribed its antibacterial properties.

Dorothy Crowfoot Hodgkin solved the structure of Thiostrepton in 1970.


Thiostrepton has been used in veterinary medicine in mastitis caused by gram-negative organisms and in dermatologic disorders. It is mostly used in complex ointments containing Neomycin, Nystatin, Thiostrepton and topical steroides. It is also active against gram-positive bacteria.

Recently, Thiostrepton has been reported to exhibit antimalarial and anticancer activities

Thiostrepton is used in molecular biology as a reagent for both positive and negative selection of genes involved in nucleotide metabolism.


Physicochemical data copied with permission from Thiostrepton product page from Fermentek