Thiamphenicol

Jump to navigation Jump to search

{{Drugbox | Verifiedfields = changed | verifiedrevid = 470606287 | IUPAC_name = 2,2-dichloro-N-{(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide | image = Thiamphenicol1.png | width = 214 | image2 = Thiamphenicol.gif

| tradename = | Drugs.com = International Drug Names | pregnancy_category = ? | legal_status = none | routes_of_administration = IV, IM, oral

| bioavailability = ? | metabolism = hepatic | elimination_half-life = 5.0 hours | excretion = renal

| CAS_number_Ref =  ☒N | CAS_number = 15318-45-3 | ATC_prefix = J01 | ATC_suffix = BA02 | ATC_supplemental = Template:ATCvet | PubChem = 27200 | DrugBank_Ref =  ☑Y | DrugBank = DB08621 | ChemSpiderID_Ref =  ☑Y | ChemSpiderID = 25315 | UNII_Ref =  ☑Y | UNII = FLQ7571NPM | KEGG_Ref =  ☑Y | KEGG = D01407 | ChEBI_Ref =  ☑Y | ChEBI = 32215 | ChEMBL_Ref =  ☒N | ChEMBL = 1236282

| C=12 | H=15 | Cl=2 | N=1 | O=5 | S=1 | molecular_weight = 356.223 g/mol | smiles = ClC(Cl)C(=O)N[C@@H]([C@H](O)c1ccc(cc1)S(=O)(=O)C)CO | InChI = 1/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1 | InChIKey = OTVAEFIXJLOWRX-NXEZZACHBV | StdInChI_Ref =  ☑Y | StdInChI = 1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1 | StdInChIKey_Ref =  ☑Y | StdInChIKey = OTVAEFIXJLOWRX-NXEZZACHSA-N }}

WikiDoc Resources for Thiamphenicol

Articles

Most recent articles on Thiamphenicol

Most cited articles on Thiamphenicol

Review articles on Thiamphenicol

Articles on Thiamphenicol in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Thiamphenicol

Images of Thiamphenicol

Photos of Thiamphenicol

Podcasts & MP3s on Thiamphenicol

Videos on Thiamphenicol

Evidence Based Medicine

Cochrane Collaboration on Thiamphenicol

Bandolier on Thiamphenicol

TRIP on Thiamphenicol

Clinical Trials

Ongoing Trials on Thiamphenicol at Clinical Trials.gov

Trial results on Thiamphenicol

Clinical Trials on Thiamphenicol at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Thiamphenicol

NICE Guidance on Thiamphenicol

NHS PRODIGY Guidance

FDA on Thiamphenicol

CDC on Thiamphenicol

Books

Books on Thiamphenicol

News

Thiamphenicol in the news

Be alerted to news on Thiamphenicol

News trends on Thiamphenicol

Commentary

Blogs on Thiamphenicol

Definitions

Definitions of Thiamphenicol

Patient Resources / Community

Patient resources on Thiamphenicol

Discussion groups on Thiamphenicol

Patient Handouts on Thiamphenicol

Directions to Hospitals Treating Thiamphenicol

Risk calculators and risk factors for Thiamphenicol

Healthcare Provider Resources

Symptoms of Thiamphenicol

Causes & Risk Factors for Thiamphenicol

Diagnostic studies for Thiamphenicol

Treatment of Thiamphenicol

Continuing Medical Education (CME)

CME Programs on Thiamphenicol

International

Thiamphenicol en Espanol

Thiamphenicol en Francais

Business

Thiamphenicol in the Marketplace

Patents on Thiamphenicol

Experimental / Informatics

List of terms related to Thiamphenicol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China, Morocco and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.

Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.[1]

Unlike chloramphenicol, thiamphenicol is not readily metabolized in cattle, poultry, sheep, or humans, but is predominantly excreted unchanged. In pigs and rats the drug is excreted both as parent drug and as thiamphenicol glucuronate (FAO, 1997).

References

  1. Fuchs FD (2004). "Tetraciclinas e cloranfenicol". In Fuchs FD, Wannmacher L, Ferreira MB (eds.). Farmacologia clínica: fundamentos da terapêutica racional (in Portuguese) (3rd ed.). Rio de Janeiro: Guanabara Koogan. p. 375. ISBN 0-7216-5944-6.

Template:Amphenicols