Tetrahydrodipicolinate N-acetyltransferase

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In enzymology, a tetrahydrodipicolinate N-acetyltransferase (EC 2.3.1.89) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O CoA + L-2-acetamido-6-oxoheptanedioate

The 3 substrates of this enzyme are acetyl-CoA, (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, and H2O, whereas its two products are CoA and L-2-acetamido-6-oxoheptanedioate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N2-acetyltransferase. Other names in common use include tetrahydrodipicolinate acetylase, tetrahydrodipicolinate:acetyl-CoA acetyltransferase, acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase, acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, and 2-N-acetyltransferase. This enzyme participates in lysine biosynthesis.

References

  • IUBMB entry for 2.3.1.89
  • BRENDA references for 2.3.1.89 (Recommended.)
  • PubMed references for 2.3.1.89
  • PubMed Central references for 2.3.1.89
  • Google Scholar references for 2.3.1.89
  • Chatterjee SP and White PJ (1982). "Activities and regulation of the enzymes of lysine biosynthesis in a lysine-excreting strain of Bacillus megaterium". J. Gen. Microbiol. 128: 1073&ndash, 1081.

External links

The CAS registry number for this enzyme class is 83588-91-4.

Gene Ontology (GO) codes


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