Terephthalate 1,2-cis-dihydrodiol dehydrogenase

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In enzymology, a terephthalate 1,2-cis-dihydrodiol dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD+ 3,4-dihydroxybenzoate + CO2 + NADH

Thus, the two substrates of this enzyme are cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate and NAD+, whereas its 3 products are 3,4-dihydroxybenzoate, CO2, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating). This enzyme participates in 2,4-dichlorobenzoate degradation.


  • IUBMB entry for
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  • Wang YZ, Zhou Y, Zylstra GJ (1995). "Molecular analysis of isophthalate and terephthalate degradation by Comamonas testosteroni YZW-D". Environ. Health. Perspect. 103 Suppl. 5: 9&ndash, 12. PMID 8565920.

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Gene Ontology (GO) codes