Tabersonine 16-O-methyltransferase

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In enzymology, a tabersonine 16-O-methyltransferase (EC is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 16-hydroxytabersonine S-adenosyl-L-homocysteine + 16-methoxytabersonine

Thus, the two substrates of this enzyme are S-adenosyl methionine and 16-hydroxytabersonine, whereas its two products are S-adenosylhomocysteine and 16-methoxytabersonine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase. Other names in common use include 11-demethyl-17-deacetylvindoline 11-methyltransferase, 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase, S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline, and 11-O-methyltransferase. This enzyme participates in indole and ipecac alkaloid biosynthesis.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM (2006). "A proteomic analysis of arsenical drug resistance in Trypanosoma brucei". Proteomics. 6: 2726&ndash, 32. PMID 16526094.
  • Fahn W, Laussermair E, Deus-Neumann B and Stockigt J (1985). "Late enzymes of vindoline biosynthesis S-Adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methylase and unspecific acetylesterase". Plant Cell Rep. 4: 337&ndash, 340.

External links

The CAS registry number for this enzyme class is 100984-95-0.

Gene Ontology (GO) codes