Transmembrane BAX inhibitor motif-containing protein 4 is a protein that in humans is encoded by the TMBIM4gene.[1][2][3] It is also known as humanGolgi anti-apoptotic protein (hGAAP) due to its function and sub-cellular localization.
Human GAAP is a protein present in the Golgi that helps regulate apoptosis, a form of programmed cell death. By regulating the fluxes of Ca+2, an increase of GAAP can help prevent apoptosis.[4][5] GAAP is also involved in promoting cell migration[6] and has been identified as a novel Golgi cation channel.[7] Other GAAPs can be foun in all eucaryotes analyzed and in some bacteria. A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox.
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