Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2gene.[1][2]
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.[2]
References
↑Imoto I, Pimkhaokham A, Watanabe T, Saito-Ohara F, Soeda E, Inazawa J (Oct 2000). "Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines". Biochem Biophys Res Commun. 276 (1): 264–70. doi:10.1006/bbrc.2000.3449. PMID11006116.
Melhuish TA, Gallo CM, Wotton D (2001). "TGIF2 interacts with histone deacetylase 1 and represses transcription". J. Biol. Chem. 276 (34): 32109–14. doi:10.1074/jbc.M103377200. PMID11427533.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID11780052.
Watanabe T, Imoto I, Katahira T, et al. (2003). "Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers". Jpn. J. Cancer Res. 93 (10): 1114–22. doi:10.1111/j.1349-7006.2002.tb01213.x. PMID12417041.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
