T-cell lymphoma invasion and metastasis-inducing protein 1

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T-cell lymphoma invasion and metastasis 1
250px
PDB rendering based on 1foe.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols TIAM1 ; FLJ36302
External IDs OMIM: 600687 MGI103306 HomoloGene2443
RNA expression pattern
File:PBB GE TIAM1 206409 at tn.png
File:PBB GE TIAM1 213135 at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 7074
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 21844

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000156299
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000002489

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q13009
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q3TQ81

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_003253 (mRNA)
NP_003244 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_009384 (mRNA)
NP_033410 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 21: 31.41 - 31.85 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 16: 89.68 -  90.03 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

T-cell lymphoma invasion and metastasis-inducing protein 1, also known as TIAM1, is a human protein gene.[1]


It modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of Rho-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. It is tightly associate with BAIAP2 as a subunit.

It was found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.

References

  1. "Entrez Gene: TIAM1 T-cell lymphoma invasion and metastasis 1".

Further reading

  • Habets GG, van der Kammen RA, Stam JC; et al. (1995). "Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin". Oncogene. 10 (7): 1371–6. PMID 7731688.
  • Habets GG, van der Kammen RA, Jenkins NA; et al. (1995). "The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16". Cytogenet. Cell Genet. 70 (1–2): 48–51. PMID 7736788.
  • Michiels F, Habets GG, Stam JC; et al. (1995). "A role for Rac in Tiam1-induced membrane ruffling and invasion". Nature. 375 (6529): 338–40. doi:10.1038/375338a0. PMID 7753201.
  • Chen H, Antonarakis SE (1996). "Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1". Genomics. 30 (1): 123–7. doi:10.1006/geno.1995.0025. PMID 8595894.
  • Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Michiels F, Stam JC, Hordijk PL; et al. (1997). "Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation". J. Cell Biol. 137 (2): 387–98. PMID 9128250.
  • Fleming IN, Elliott CM, Buchanan FG; et al. (1999). "Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation". J. Biol. Chem. 274 (18): 12753–8. PMID 10212259.
  • Bourguignon LY, Zhu H, Shao L, Chen YW (2000). "CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration". J. Biol. Chem. 275 (3): 1829–38. PMID 10636882.
  • Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
  • Crompton AM, Foley LH, Wood A; et al. (2000). "Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands". J. Biol. Chem. 275 (33): 25751–9. doi:10.1074/jbc.M002050200. PMID 10835422.
  • Bourguignon LY, Zhu H, Shao L, Chen YW (2000). "Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration". J. Cell Biol. 150 (1): 177–91. PMID 10893266.
  • Worthylake DK, Rossman KL, Sondek J (2001). "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1". Nature. 408 (6813): 682–8. doi:10.1038/35047014. PMID 11130063.
  • Otsuki Y, Tanaka M, Yoshii S; et al. (2001). "Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4385–90. doi:10.1073/pnas.071411598. PMID 11274357.
  • Gao Y, Xing J, Streuli M; et al. (2002). "Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors". J. Biol. Chem. 276 (50): 47530–41. doi:10.1074/jbc.M108865200. PMID 11595749.
  • Buchsbaum RJ, Connolly BA, Feig LA (2002). "Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade". Mol. Cell. Biol. 22 (12): 4073–85. PMID 12024021.
  • Lambert JM, Lambert QT, Reuther GW; et al. (2002). "Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism". Nat. Cell Biol. 4 (8): 621–5. doi:10.1038/ncb833. PMID 12134164.
  • Wennerberg K, Ellerbroek SM, Liu RY; et al. (2003). "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
  • Otsuki Y, Tanaka M, Kamo T; et al. (2003). "Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts". J. Biol. Chem. 278 (7): 5132–40. doi:10.1074/jbc.M206733200. PMID 12446731.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Buchsbaum RJ, Connolly BA, Feig LA (2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". J. Biol. Chem. 278 (21): 18833–41. doi:10.1074/jbc.M207876200. PMID 12531897.

External links


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