Substantia gelatinosa of Rolando

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Substantia gelatinosa of Rolando
File:Medulla spinalis - Substantia grisea - English.svg
Substantia gelatinosa of Rolando is Rexed lamina II, labeled at upper left.
Latin substantia gelatinosa cornu posterioris medullae spinalis
Gray's subject #185 753
MeSH Substantia+Gelatinosa
Dorlands/Elsevier s_27/12766752

The apex of the posterior horn of the spinal cord is capped by a V-shaped or crescentic mass of translucent, gelatinous neuroglia, termed the substantia gelatinosa of Rolando (or gelatinous substance of posterior horn of spinal cord), which contains both neuroglia cells, and small nerve cells. The gelatinous appearance is due to a very low concentration of myelinated fibers.

It is named for Luigi Rolando.

It corresponds to Rexed lamina II.


Many μ- and к-opioid receptors, presynaptic and postsynaptic, are found on these nerve cells; they can be targeted to manage pain of distal origin.

C fibers terminate at this layer.

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This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained herein may be outdated. Please edit the article if this is the case, and feel free to remove this notice when it is no longer relevant.

It is not known, however, if cocaine acts on this pathway.