Sorangium cellulosum

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Sorangium cellulosum is a soil-dwelling Gram-negative bacteria of the group myxobacteria.[1] It is motile and shows gliding motility. It has an unusually-large genome 12,200,000 base pairs in size.[2]

Clinical use

Metabolites secreted by Sorangium cellulosum known as Epothilones have been noted to have antineoplastic activity. This has led to the development of analogs which mimic its activity. One such analog, known as Ixabepilone has recently undergone clinical trial in the treatment of metastatic breast cancer and is currently under new drug application review by the US FDA. [1]


References

  1. Julien B, Fehd R (2003). "Development of a mariner-based transposon for use in Sorangium cellulosum.". Appl Environ Microbiol 69 (10): 6299-301. PMID 14532095.
  2. Pradella S, Hans A, Spröer C, Reichenbach H, Gerth K, Beyer S (2002). "Characterisation, genome size and genetic manipulation of the myxobacterium Sorangium cellulosum So ce56.". Arch Microbiol 178 (6): 484-92. PMID 12420170.
it:Polyangium cellulosum

uk:Polyangium cellulosum


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