Sezary syndrome differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
Sezary syndrome must be differentiated from Eczema, Psoriasis, Pityriasis rubra pilaris, dermatitis, Hypereosinophilic syndrome, adult T-cell leukemia, atopic dermatitis, contact dermatitis, chronic actinic dermatitis,scabies, Drug eruption, graft versus host disease.
Differentiating Sezary syndrome from other Diseases
- Sezary syndrome must be differentiated from other diseases that cause:[1][2][3][4][5]
- Mycosis fangoides
- Sezaruy syndrome(SS) is more symptoI contrast to patch or plaque mycosis fungoides (MF), SS is much more symptomatic. Sezary syndrome patients tend to present with diffuse skin involvement,not like mycosis fungoides usually evolve through patches and plaques to erythroderma [6]
- In Sezary syndrome infiltration of skin is generally much less dense than plaque in mycosis fungoides (MF)
- Eczema
- Psoriasis
- Pityriasis rubra pilaris
- dermatitis
- Hypereosinophilic syndrome
- Adult T-cell leukemia
- Atopic dermatitis
- Contact dermatitis
- Chronic actinic dermatitis
- Scabies
- Drug eruption
- Graft versus host disease
- Mycosis fangoides
References
- ↑ Yamashita T, Abbade LP, Marques ME, Marques SA (2012). "Mycosis fungoides and Sézary syndrome: clinical, histopathological and immunohistochemical review and update". An Bras Dermatol. 87 (6): 817–28, quiz 829–30. PMC 3699909. PMID 23197199.
- ↑ Olek-Hrab K, Silny W (March 2014). "Diagnostics in mycosis fungoides and Sezary syndrome". Rep Pract Oncol Radiother. 19 (2): 72–6. doi:10.1016/j.rpor.2013.11.001. PMC 4054990. PMID 24936324.
- ↑ Klemke CD, Brade J, Weckesser S, Sachse MM, Booken N, Neumaier M, Goerdt S, Nebe TC (September 2008). "The diagnosis of Sézary syndrome on peripheral blood by flow cytometry requires the use of multiple markers". Br. J. Dermatol. 159 (4): 871–80. doi:10.1111/j.1365-2133.2008.08739.x. PMID 18652582.
- ↑ Scala E, Abeni D, Palazzo P, Liso M, Pomponi D, Lombardo G, Picchio MC, Narducci MG, Russo G, Mari A (2012). "Specific IgE toward allergenic molecules is a new prognostic marker in patients with Sézary syndrome". Int. Arch. Allergy Immunol. 157 (2): 159–67. doi:10.1159/000327553. PMID 21985996.
- ↑ Chu AC, Robinson D, Hawk JL, Meacham R, Spittle MF, Smith NP (February 1986). "Immunologic differentiation of the Sézary syndrome due to cutaneous T-cell lymphoma and chronic actinic dermatitis". J. Invest. Dermatol. 86 (2): 134–7. PMID 3528307.
- ↑ Chand K, Sayal SK, Chand S (April 2007). "Cutaneous T-Cell Lymphoma (Mycosis Fungoides)". Med J Armed Forces India. 63 (2): 188–90. doi:10.1016/S0377-1237(07)80076-1. PMC 4925357. PMID 27407986.