Set domain containing 1b

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

SET domain containing 1B is a protein that in humans is encoded by the SETD1B gene.

Function

SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008].

Further reading

• Lee JH, Skalnik DG (2012). "Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation". PLoS ONE. 7 (8): e42965. doi:10.1371/journal.pone.0042965. PMC 3424240. PMID 22927943.
• Choi YJ, Oh HR, Choi MR, Gwak M, An CH, Chung YJ, Yoo NJ, Lee SH (2014). "Frameshift mutation of a histone methylation-related gene SETD1B and its regional heterogeneity in gastric and colorectal cancers with high microsatellite instability". Hum. Pathol. 45 (8): 1674–81. doi:10.1016/j.humpath.2014.04.013. PMID 24925220.
• Labonne JD, Lee KH, Iwase S, Kong IK, Diamond MP, Layman LC, Kim CH, Kim HG (2016). "An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability". Hum. Genet. 135 (7): 757–71. doi:10.1007/s00439-016-1668-4. PMID 27106595.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.